The role of the N-terminal and mid-region residues of substance P in regulating functional selectivity at the tachykinin NK1 receptor

European Journal of Pharmacology

Volumn 592, Issue 1-3, 2008, Pages 1-6

  Perrine, Shane A ^a,b   Beard, Debbie J ^c   Young, John K ^c   Simmons, Mark A ^a,b  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^b KENT STATE UNIVERSITY   (United States)

^c MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Calcium responses; Desensitization; G protein coupled receptor; NK1 receptor; Nuclear magnetic resonance; Receptor binding; Substance P; Tachykinin

Indexed keywords

ALANINE; ARGININE; CALCIUM; GLUTAMINE; LIGAND; NEUROKININ 1 RECEPTOR; RANATACHYKININ C; SERINE; SUBSTANCE P; TACHYKININ DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; DRUG RECEPTOR BINDING; GENE DELETION; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CALCIUM SIGNALING; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; IODINE RADIOISOTOPES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RATS; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 49749104818     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.097     Document Type: Article

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