Synthesis and anticonvulsant evaluation of 6-amino-1,4-oxazepane-3,5-dione derivatives

Archives of Pharmacal Research

Volumn 31, Issue 7, 2008, Pages 838-842

  Sharma, Gitalee ^a   Park, Jin Yup ^a   Park, Min Soo ^a  

^a Kyungsung University   (South Korea)

Author keywords

6 Amino 1,4 oxazepine 3,5 dione; Anticonvulsant; Glutarimides; MES test; PTZ test; Succinimides

Indexed keywords

6 AMINO 1,4 OXAZEPANE 3,5 DIONE; 6-AMINO-1,4-OXAZEPANE-3,5-DIONE; ANTICONVULSIVE AGENT; CONVULSANT AGENT; DIAGNOSTIC AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; OXAZEPINE DERIVATIVE; PENTETRAZOLE; VALPROIC ACID;

ANIMAL; ARTICLE; ELECTRIC SHOCK; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MOUSE; SYNTHESIS;

ANIMALS; ANTICONVULSANTS; CONVULSANTS; ELECTROSHOCK; INDICATORS AND REAGENTS; MALE; MICE; MICE, INBRED ICR; OXAZEPINES; PENTYLENETETRAZOLE; VALPROIC ACID;

EID: 49749092012     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-1235-0     Document Type: Article

References (10)

1. Byun, A., Choi, J. W., Moon, K. H., Lee C K., and Park, M. S., Synthesis and Anticonvulsant Activities of N-Cbz-α-aminoglutarimidooxy Carboxylate Derivatives. Arch. Pharm. Res., 29, 459-463 (2006).
2. Dandiya, P. C. and Collumbine, H. J., Studies on Acorus calamus (III): some pharmacological actions of the volatile oil. Journal of Pharmacology and Experimental Therapy, 195, 385-389 (1959).
3. Jung, K., Son, K., Kim, M., Jung, K., Lee, J., Choi, J., Lee, E-s., and Park, M., The Effect of N-alkoxycarbonyl groups on anticonvulsant activities of N-alkyloxycarbonyl-α-amino-N-methylsuccinimides. Arch. Pharm. Res., 21, 759-763 (1998).
4. Kim, M, Byun, A., Choi, J. W., Moon, K. H., Lee, C. K., and Park, M. S., Synthesis and anticonvulsant evaluations of N-Cbz-α-amino-N- alkoxyglutarimides. Arch. Pharm. Res., 27, 151-155 (2004).
5. Lee, J., Son, K., Kim, M., Jung, K., Choi, J., and Park, M., The effect of N-substituted alkyl groups on the anticonvulsant activities of N-cbz-α-amino-N-alkylsiccinimides. Arch. Pharm. Res., 20, 53-57 (1997).
6. Lee, J., Son, K., Kim, M., Jung, K., Choi, J., Lee, E., and Park, M., The Effect of N-substituted alkyl groups on anticonvulsant activities of N-cbz-α-amino-N-alkylglutarimides. Arch. Pharm. Res., 22, 491-495 (1999).
7. Son, K., Jung, K., Kim, M., Lee, J., Choi, J., Lee, E., and Park, M., The effect of N-alkyloxycarbonyl group on the anticonvulsant activities of N-alkyloxycarbonyl-α-aminoglutarimides. Arch. Pharm. Res., 21, 764-768 (1998).
8. Swinyard, E. A., Woodhead, J. H., White, H. S., and Frankline, M. R., General Principles, Experimental Section, Quantitative and Evaluation of Anticonvulsants in Antiepileptic Drugs, 3rd Ed: In Levy, R. et al. (Eds.), Ravan Press, N. Y., 1989, p. 88
9. Williams D. A. and Lemke, T. L., Foye's Principle of Medicinal Chemistry, Lippincott Williams & Wilkins, Fifth Ed., pp. 370-383, (2002).
10. Witak, D. T., Seth, S. K., Baizman, E. R., Wiebel, S. L., and Wolf, H. H., Para-substituted N-acetyl-L(S)-and D(R)-α-amino-N-phenylsuccinimide and glutarimide. Substituent effect on stereoselective anticonvulsant activity. J. Med. Chem., 15, 1117-1123 (1972).