The effect of N-substituted alkyl groups on the anticonvulsant activities of N-Cbz-α-amino-N-alkylsuccinimides

Archives of Pharmacal Research

Volumn 20, Issue 1, 1997, Pages 53-57

  Lee, Jaewon ^a   Son, Kichun ^b   Jung, Kyungim ^b   Choi, Jongwon ^b   Park, Minsoo ^b  

^a Koshin Medical Center Pusan   (South Korea)

^b Kyungsung University   (South Korea)

Author keywords

Anticonvulsant; Imide; Maximal electric shock seizure(MES); N Cbz aminosuccinimide; Pentylenetetrazole induced seizure(PTZ); Structure activity relationship

Indexed keywords

EID: 20544466208     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02974042     Document Type: Article

References (4)

1. Lee, J., Choi, J., and Park, M., Synthesis and anticonvulsant evaluation of a series of (R)- and (S)-N-Cbz-α-aminosuccinimide and their structure activity relationship. Arch. Pharm. Res., 19, 312-316 (1996).
2. Park, M., Lee, J., and Choi., J., Synthesis and anticonvulsant evaluation of a series of (R)- and (S)-N-Cbz-α-aminoglutarimide and succinimide. Bioorg. Med. Chem. Lett., 6, 1298-1302 (1996).
3. Swinyard, E. A., Woodhead, J. H., White, H. S. and Frankline, M. R., General Principles, Experimental Section, Quantification and Evaluation of Anticonvulsants in Antiepileptic Drugs, 3rd Ed: In Levy, R., et al., (Eds.), Ravan Press, N. Y., 1989, p. 88.
4. Witak, D. T., Seth, S. K., Baizman, E. R., Wiebel, S. L. and Wolf, H. H., Para-substituted N-acetyl-L(S)-and-D(R)-α-amino-N-phenylsuccinimides and -glutarimides. Substituent effects on stereoselective anticonvulsant activity. J. Med. Chem., 15, 1117-1123 (1972).