The effect of N-alkyloxycarbonyl group on the anticonvulsant activities of N-alkyloxycarbonyl-α-aminoglutarimides

Archives of Pharmacal Research

Volumn 21, Issue 6, 1998, Pages 764-768

  Son, Kichun ^a   Jung, Kyungim ^a   Kim, Minjeong ^a   Lee, Jaewon ^b   Choi, Jongwon ^a   Lee, Eung Seok ^c   Park, Minsoo ^a  

^a Kyungsung University   (South Korea)

^b Koshin Medical Center Pusan   (South Korea)

^c Yeungnam University   (South Korea)

Author keywords

Aminoglutarimide; Anticonvulsant; MES test; N Alkyloxycarbonyl aminoglutarimide; PTZ test

Indexed keywords

ANTICONVULSIVE AGENT;

ANIMAL; ARTICLE; CHEMISTRY; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; SYNTHESIS;

ANIMALS; ANTICONVULSANTS; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED ICR;

EID: 0032240452     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976773     Document Type: Article

References (4)

1. Lee, J., Choi, J., Park, M., Synthesis and anticonvulsant evaluation of a series of N-cbz-α-aminoglutarimides. Arch. Pharm. Res., 19, 248-250 (1996).
2. Park, M., Lee, J., Choi, J., Synthesis and anticonvulsant evaluation of a seies of (R)- and (S)-N-cbz-α-aminoglutarimide and succinimide. Bioorg. Med. Chem. Lett., 6, 1297-1302 (1996).
3. Swinyard, E. A., Woodhead, J. H., White, H. S. and Frankline, M. R., General Priciples, Experimental Section, Quantitative and Evaluation of Anticonvulsants in Antiepileptic Drugs, 3rd Ed: In Levy, R., et al., (Eds.), Ravan Press, N. Y., 1989, p. 88.
4. Witak, D. T., Seth, S. K., Baizman, E. R., Wiebel, S. L., and Wolf, H. H., Para-substituted N-acetyl-L(S)- and D(R)-α-amino-N-phenylsuccinimide and glutarimide. Substituent effect on stereoselective anticonvulsant activity. J. Med. Chem., 15, 1117-1123 (1972).