Gene expression profiles in the cerebellum and hippocampus following exposure to a neurotoxicant, Aroclor 1254: Developmental effects

Toxicology and Applied Pharmacology

Volumn 231, Issue 2, 2008, Pages 165-178

  Royland, Joyce E ^a   Wu, Jinfang ^b   Zawia, Nasser H ^b   Kodavanti, Prasada Rao S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Aroclor 1254; Development; Genomics; Learning and memory; Nervous system; Polychlorinated biphenyls

Indexed keywords

AROCLOR 1254; POLYCHLORINATED BIPHENYL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HIPPOCAMPUS; LEARNING; MEMORY; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANIMALS, NEWBORN; ANTITHYROID AGENTS; AROCLOR 1254; CELL CYCLE; CEREBELLUM; CHILD; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HIPPOCAMPUS; HUMANS; MALE; MATERNAL EXPOSURE; NEUROTOXINS; PREGNANCY; RATS; RATS, LONG-EVANS; SYNAPTIC TRANSMISSION;

ANIMALIA; RATTUS;

EID: 49749083063     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.04.022     Document Type: Article

References (60)

1. Ashburner M., Ball C.A., Blake J.A., Botstein D., Butler H., Cherry J.M., Davis A.P., Dolinski K., Dwight S.S., Eppig J.T., Harris M.A., Hill D.P., Issel-Tarver L., Kasarskis A., Lewis S., Matese J.C., Richardson J.E., Ringwald M., Rubin G.M., and Sherlock G. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25 (2000) 25-29
2. ATSDAR. Toxicological Profile for Polychlorinated Biphenyls (1999), Research Triangle Institute, Atlanta, GA ATSDR document
3. Behar T.N., Li Y.X., Tran H.T., Ma W., Dunlap V., Scott C., and Barker J.L. GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms. J. Neurosci. 16 (1996) 1808-1818
4. Behar T.N., Scott C.A., Greene C.L., Wen X., Smith S.V., Maric D., Liu Q.Y., Colton C.A., and Barker J.L. Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration. J. Neurosci. 19 (1999) 4449-4461
5. Behar T.N., Schaffner A.E., Scott C.A., Greene C.L., and Barker J.L. GABA receptor antagonists modulate postmitotic cell migration in slice cultures of embryonic rat cortex. Cereb. Cortex 10 (2000) 899-909
6. Boersma E.R., and Lanting C.I. Environmental exposure to polychlorinated biphenyls (PCBs) and dioxins. Consequences for longterm neurological and cognitive development of the child lactation. Adv. Exp. Med. Biol. 478 (2000) 271-287
7. Bushnell P.J., Moser V.C., MacPhail R.C., Oshiro W.M., Derr-Yellin E.C., Phillips P.M., and Kodavanti P.R. Neurobehavioral assessments of rats perinatally exposed to a commercial mixture of polychlorinated biphenyls. Toxicol. Sci. 68 (2002) 109-120
8. Cameron H.A., Hazel T.G., and McKay R.D. Regulation of neurogenesis by growth factors and neurotransmitters. J. Neurobiol. 36 (1998) 287-306
9. Carpenter D.O. Polychlorinated biphenyls and human health. Int. J. Occup. Med. Environ. Health 11 (1998) 291-303
10. Corrigan F.M., Murray L., Wyatt C.L., and Shore R.F. Di-ortho-substituted polychlorinated biphenyls in caudate nucleus in Parkinson's disease. Exp. Neurol. 150 (1998) 339-342
11. Crofton K.M., Kodavanti P.R.S., Derr-Yellin E.C., Casey A.C., and Kehn L.S. PCBs, thyroid hormones, and ototoxicity in rats: cross-fostering experiments demonstrate the impact of postnatal lactation exposure. Toxicol. Sci. 57 (2000) 131-140
12. Dai M., Wang P., Boyd A.D., Kostov G., Athey B., Jones E.G., Bunney W.E., Myers R.M., Speed T.P., Akil H., Watson S.J., and Meng F. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res. 33 (2005) e175
13. Faroon O., Jones D., and de Rosa C. Effects of polychlorinated biphenyls on the nervous system. Toxicol. Ind. Health 16 (2001) 305-333
14. Fiszman M.L., Borodinsky L.N., and Neale J.H. GABA induces proliferation of immature cerebellar granule cells grown in vitro. Brain Res. 115 (1999) 1-8
15. Foran D.R., and Peterson A.C. Myelin acquisition in the central nervous system of the mouse revealed by an MBP-Lac Z transgene. J. Neurosci. 12 (1992) 4890-4897
16. Geller A.M., Oshiro W.M., Haykal-Coates N., Kodavanti P.R., and Bushnell P.J. Gender-dependent behavioral and sensory effects of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) in rats. Toxicol. Sci. 59 (2001) 268-277
17. Hany J., Lilienthal H., Sarasin A., Roth-Harer A., Fastabend A., Dunemann L., Lichtensteiger W., and Winneke G. Developmental exposure of rats to a reconstituted PCB mixture or Aroclor 1254: effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behavior. Toxicol. Appl. Pharmacol. 158 (1999) 231-243
18. Harbig J., Sprinkle R., and Enkemann S.A. A sequence-based identification of the genes detected by probesets on the Affymetrix U133 plus 2.0 array. Nucleic Acids Res. 33 (2005) e31
19. Hernandez-Muela S., Mulas F., and Mattos L. The contribution of the cerebellum to cognitive process. Rev. Neurol. 40 (2005) S57-S64
20. Herrick R.F., Lefkowits D.J., and Weymouth G.A. Soil contamination from PCB-containing buildings. Environ. Health Perspect. 115 (2007) 173-175
21. Hsiao S.H., West J.R., Mahoney J.C., and Frye G.D. Postnatal ethanol exposure blunts upregulation of GABAA receptor currents in Purkinje neurons. Brain Res. 832 (1999) 124-135
22. Jacobson J.L., and Jacobson S.W. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N. Engl. J. Med. 335 (1996) 783-789
23. Jacobson J.L., Janisse J., Banerjee M., Jester J., Jacobson S.W., and Ager J.W. A benchmark dose analysis of prenatal exposure to polychlorinated biphenyls. Environ. Health Perspect. 110 (2002) 393-398
24. Juarez de Ku L.M., Sharma-Stokkermans M., and Meserve L.A. Thyroxine normalizes polychlorinated bipheyl (PCB) dose-related depression of choline acetyltransferase (ChAT) activity in hippocampus and basal forebrain of 15-day old rats. Toxicology 94 (1994) 19-30
25. Kodavanti P.R. Intracellular signaling and developmental neurotoxicity. In: Zawia N.H. (Ed). Molecular Neurotoxicology Environmental Agents and Transcription-Transduction Coupling (2004), CRC Press, Boca Raton, FL 151-182
26. Kodavanti P.R.S. Neurotoxicity of persistent organic pollutants: possible mode(s) of action and further considerations. Dose-Response 3 (2005) 273-305
27. Kodavanti P.R., Ward T.R., Derr-Yellin E.C., Mundy W.R., Casey A.C., Bush B., and Tilson H.A. Congener-specific distribution of polychlorinated biphenyls in brain regions, blood, liver, and fat of adult rats following repeated exposure to Aroclor 1254. Toxicol. Appl. Pharmacol. 153 (1998) 199-210
28. Kodavanti P.R.S., Mundy W.R., Derr-Yellin E.C., and Tilson H.A. Developmental exposure to Aroclor 1254 alters calcium buffering and protein kinase C activity in the brain. Toxicologist 54 (2000) 76-77
29. Kodavanti P.R.S., Kannan N., Yamashita N., Derr-Yellin E.C., Ward T.R., Burgin D.E., Tilson H.A., and Birnbaum L.S. Differential effects of two lots of Aroclor 1254: congener-specific analysis and neurochemical end points. Environ. Health Perspect. 109 (2001) 1153-1161
30. Koopman-Esseboom C., Weisglas-Kuperus N., de Ridder M.A., Van der Paauw C.G., Tuinstra L.G., and Sauer P.J. Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development. Pediatrics 97 (1996) 700-706
31. Lai T.J., Guo Y.L., Guo N.W., and Hsu C.C. Effect of prenatal exposure to polychlorinated biphenyls on cognitive development in children: a longitudinal study in Taiwan. Br. J. Psychiatr., Suppl. 40 (2001) s49-s52
32. Lein P.J., Yang D., Bachstetter A.D., Tilson H.A., Harry G.J., Mervis R.F., and Kodavanti P.R. Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls. Environ. Health Perspect. 115 (2007) 556-563
33. Liu C.L., Lin Y.R., Chan M.H., and Chen H.H. Effects of toluene exposure during brain growth spurt on GABA(A) receptor-mediated functions in juvenile rats. Toxicol. Sci. 95 (2007) 443-451
34. - ΔΔCt method. Methods 25 (2001) 402-408
35. Mariussen E., Myhre O., Reistad T., and Fonnum F. The polychlorinated biphenyl mixture Aroclor 1254 induces death of rat cerebellar granule cells: the involvement of the N-methyl-d-aspartate receptor and reactive oxygen species. Toxicol. Appl. Pharmacol. 179 (2002) 137-144
36. Mecham B.H., Klus G.T., Strovel J., Augustus M., Byrne D., Bozso P., Wetmore D.Z., Mariani T.J., Kohane I.S., and Szallasi Z. Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements. Nucleic Acids Res. 32 (2004) 1-8
37. Mecham B.H., Wetmore D.Z., Szallasi Z., Sadovsky Y., Kohane I., and Mariani T.J. Increased measurement accuracy for sequence-verified microarray probes. Physiol. Genomics 18 (2004) 308-315
38. Mejia-Gervacio S., and Marty A. Control of interneuron firing pattern by axonal autoreceptors in the juvenile rat cerebellum. J. Physiol. 571 (2006) 43-55
39. Miale I.L., and Sidman R.L. An autoradiographic analysis of histogenesis in the mouse cerebellum. Exp. Neurology 4 (1961) 277-296
40. Miranda-Contreras L., Davila-Ovalles R., Benitez-Diaz P., Pena-Contreras Z., and Palacios-Pru E. Effects of prenatal paraquat and mancozeb exposure on amino acid synaptic transmission in developing mouse cerebellar cortex. Brain Res. 160 (2005) 19-27
41. Morse D.C., Wehler E.K., Wesseling W., Koeman J.H., and Brouwer A. Alterations in rat brain thyroid hormone status following pre- and post-natal exposure to polychlorinated biphenyls (Aroclor 1254). Toxicol. Appl. Pharmacol. 136 (1996) 269-279
42. Nguyen L., Rigo J.M., Rocher V., Belachew S., Malgrange B., Rogister B., Leprince P., and Moonen G. Neurotransmitters as early signals for central nervous system development. Cell Tissue Res. 305 (2001) 187-202
43. Padhi B.K., Pelletier G., Williams A., Berndt-Weis L., Yauk C., Bowers W.J., and Chu I. Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides. Toxicol. Lett. 176 (2008) 93-103
44. Ribas-Fito N., Sala M., Kogevinas M., and Sunyer J. Polychlorinated biphenyls (PCBs) and neurological development in children: a systematic review. J. Epidemiol. Community Health 55 (2001) 537-546
45. Rice D.C. Behavioral impairment produced by low-level postnatal PCB exposure in monkeys. Environ. Res. 80 (1999) S113-S121
46. Rice D.C., and Hayward S. Effects of postnatal exposure to a PCB mixture in monkeys on nonspatial discrimination reversal and delayed alternation performance. Neurotoxicology 18 (1997) 479-494
47. Rodier P.M. Chronology of neuron development: animal studies and their clinical implications. Dev. Med. Child Neurol. 22 (1980) 525-545
48. Rogan W.J., and Gladen B.C. Neurotoxicology of PCBs and related compounds. Neurotoxicology 13 (1992) 27-35
49. Royland, J.E., Kodavanti, P.R.S. 2008. Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action. Toxicol Appl Pharmacol (companion paper).
50. Schantz S.L., Levin E.D., Bowman R.E., Heironimus M.P., and Laughlin N.K. Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys. Neurotoxicol. Teratol. 11 (1989) 243-250
51. Seegal R.F. Epidemiological and laboratory evidence of PCB-induced neurotoxicity. Crit. Rev. Toxicol. 26 (1996) 709-737
52. Seo J.a.E.P.H. Probe set algorithms: is there a rational best bet?. BMC Bioinformatics 7 (2006) 395-402
53. Squire L.R. Memory and the hippocampus: a synthesis from findings with rats, monkeys and humans. Psychol. Rev. 99 (1992) 195-231
54. Swanson G.M., Ratcliffe H.E., and Fischer L.J. Human exposure to polychlorinated biphenyls: a critical assessment of the evidence for adverse health effects. Regul. Toxicol. Pharmacol. 21 (1995) 136-150
55. Tilson H.A., and Kodavanti P.R. The neurotoxicity of polychlorinated biphenyls. Neurotoxicology 19 (1998) 517-525
56. Vreugdenhil H.J., Van Zanten G.A., Brocaar M.P., Mulder P.G., and Weisglas-Kuperus N. Prenatal exposure to polychlorinated biphenyls and breastfeeding: opposing effects on auditory P300 latencies in 9-year-old Dutch children. Dev. Med. Child Neurol. 46 (2004) 398-405
57. Wang Y., Li X., Li A., Wang T., Zhang Q., Wang P., Fu J., and Jiang G. Effect of municipal sewage treatment plant effluent on bioaccumulation of polychlorinated biphenyls and ploybrominated diphenyl ethers in recipient water. Environ. Sci. Technol. 41 (2007) 6026-6032
58. Waters M., Boorman G., Bushel P., Cunningham M., Irwin R., Merrick A., Olden K., Paules R., Selkirk J., Stasiewicz C., Weis B., Van Houten B., Walker N., and Tennant R. Systems toxicology and the chemical effects in biological systems knowledge base. Environ. Health Perspect. 111 (2003) 811-824
59. Widholm J.J., Villareal S., Seegal R.F., and Schantz S.L. Spatial alternation deficits following developmental exposure to Aroclor 1254 and/or methylmercury in rats. Toxicol. Sci. 82 (2004) 577-589
60. Wu, Z., Irizarry, R.A., Gentleman, R., Murillo, F.M., Spencer, F., 2003. A model based background adjustment for oligonucliotide expression arrays. Technical Report. John Hopkins University, Dept. Biostatistics Working Papers, Baltimore.