Gender-dependent behavioral and sensory effects of a commercial mixture of polycholorinated biphenyls (Aroclor 1254) in rats

Toxicological Sciences

Volumn 59, Issue 2, 2001, Pages 268-277

  Geller, A M ^a   Oshiro, W M ^a   Haykal Coastes, N ^a   Kodavanti, P R S ^a   Bushnell, P J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Aroclor 1254; Autoshaping; Gender dependent effects; Polychlorinated biphenyls; Visual thresholds

Indexed keywords

AROCLOR 1254; AROMATIC HYDROCARBON RECEPTOR; POLYCHLORINATED BIPHENYL DERIVATIVE;

AGED; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL BINDING; COGNITION; CONTROLLED STUDY; DARKNESS; DEVELOPMENTAL BIOLOGY; EXPERIMENTAL ANIMAL; EXPOSURE; FEMALE; GESTATIONAL AGE; HYPOTHESIS; ILLUMINATION; INSTRUMENTAL CONDITIONING; LIGHT DARK CYCLE; MALE; NEWBORN; NONHUMAN; PERCEPTIVE DISCRIMINATION; PERCEPTIVE THRESHOLD; PERINATAL PERIOD; PHOTOSTIMULATION; RAT; RAT STRAIN; SENSORY SYSTEM PARAMETERS; SEX DIFFERENCE; TRAINING;

ANIMALS; ANIMALS, NEWBORN; AROCLOR 1254; ATTENTION; BEHAVIOR, ANIMAL; BODY WEIGHT; CONDITIONING, OPERANT; DISCRIMINATION LEARNING; ELECTRORETINOGRAPHY; ENVIRONMENTAL POLLUTANTS; EVOKED POTENTIALS, VISUAL; FEMALE; MALE; PREGNANCY; RATS; RATS, LONG-EVANS; SEX FACTORS;

ANIMALIA;

EID: 0035125133     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/59.2.268     Document Type: Article

References (61)

1. A Lotus 1-2-3-based system for recording and maintaining body weight of laboratory animals
2. Inhibition of long-term potentiation in developing rat visual cortex but not hippocampus by in utero exposure to polychlorinated biphenyls
3. Clinical electroretinography
4. Partial demasculinization and feminization of sex behavior in male rats by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin is not associated with alterations in differentiated brain nuclei
5. Reproductive toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male rats: Different effects of in utero versus lactational exposure
6. Behavioral effects of acute p-xylene inhalation in rats: Autoshaping, motor activity, and reversal learning
7. Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats
8. Effects of unilateral removal of basal forebrain cholinergic neurons on cued target detection in rats
9. Sustained attention and visual thresholds in rats exposed perinatally to Aroclor 1254
10. Effects of toluene inhalation on detection of auditory signals in rats
11. Detection of visual signals by rats: Effects of chlordiazepoxide and cholinergic and adrenergic drugs on sustained attention
12. Behavioral assessment of learning and attention in rats exposed perinatally to 3,3′,4,4′,5-pentachlorobiphenyl
13. Assessing the cancer risk from environmental PCBs
14. Hydroxylated polycholorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure-activity relationships
15. Low-frequency hearing loss following perinatal exposure to 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) in rats
16. Concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from Greenland
17. Complete PCB congener distributions for 17 Aroclor mixtures determined by 3 HRGC systems optimized for comprehensive, quantitative, congener-specific analysis
18. Behavioral and electrophysiological estimates of visual thresholds in awake rats treated with 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126)
19. Thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to Aroclor 1254 in rats
20. Gender-related decrease in Raven's progressive matrices scores in children prenatally exposed to polychlorinated biphenyls and related contaminants
21. Neonatal exposure to Aroclor 1254: Effects on adult hepatic testosterone hydroxylase activities
22. A system for simultaneous multiple subject, multiple stimulus modality, and multiple channel collection and analysis of sensory evoked potentials
23. Developmental exposure of rats to a reconstituted PCB mixture or Aroclor 1254: Effects on organ weights, aromatase activity, sex hormone levels, and sweet preference levels
24. Sensitivity to light
25. A 4-year follow-up study of children born to consumers of Lake Michigan fish
26. Intellectual impairment in children exposed to polychlorinated biphenyls in utero
27. Effects of prenatal PCB exposure on cognitive processing efficiency and sustained attention
28. The effect of intrauterine PCB exposure on visual recognition memory
29. The form of the auto-shaped response with food or water reinforcers
30. Sex difference in dendritic response to differential experience in the rat visual cortex
31. Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: A novel pathway explaining the estrogenic activity of PCBs
32. Estrogen receptor expression in bovine and rat retinas
33. Differential effects of Aroclor 1254 mixtures with two lot numbers: Intracellular calcium buffering and protein kinase C translocation in rat brain
34. Structure-activity relationships of potentially neurotoxic PCB congeners in the rat
35. 2+ sequestration in rat cerebellum by polychlorinated biphenyl mixtures and congeners
36. Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infant's mental and psychomotor development
37. Sex-dependent effects of maternal PCB exposure on the electroretinogram in adult rats
38. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: Quantitative structure-activity relationships
39. Dark adapted thresholds in young RCS rats
40. A morphological and morphometric analysis of the optic nerve in the hypothyroid rat
41. In utero and lactational exposure of male rats to 2,3,7,8-tetracholordibenzo-p-dioxin 2. Effects on sexual behavior and the regulation of luteinizing hormone secretion in adulthood
42. Neurobehavioral effects of developmental Aroclor 1254 exposure
43. Behavioral estimates of absolute threshold in rat
44. Effect of congential hyothyroidism on cell density in the ganglion cell layer of rat retina
45. Estrogen receptor in the human eye: Influence of gender and age on gene expression
46. Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age
47. Effects of postnatal exposure to a PCB mixture in monkeys on nonspatial discrimination reversal and delayed alternation performance
48. Polychlorinated biphenyls (PCBs) and dichlorophenyl dichloroethylene (DDE) in human milk: Effects on growth, morbidity, and duration of lactation
49. Long-term effects on reproductive parameters in female rats after translactational exposure to PCBs
50. Long-term neurobehavioral effects of perinatal polychlorinated biphenyl (PCB) exposure in monkeys
51. Spatial learning deficits in adult rats exposed to ortho-substituted PCB congeners during gestation and lactation
52. Vernier and grating acuity in adult hooded rats: The influence of sex
53. PCB problems in the future: Foresight from current knowledge
54. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs, for humans and wildlife
55. D-Amphetamine differentially affects low, but not high response rates of male and female Wistar rats
56. Acquisition and reversal of a discriminated autoshaped response in male and female rats: Effects of long or short and fixed or variable intertrial interval durations
57. Behavioral differences between male and female Wistar rats on DRL schedules: Effect of stimuli promoting collateral activities
58. Behavioral differences between male and female Wistar rats in food rewarded lever holding