B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells

PLoS ONE

Volumn 3, Issue 6, 2008, Pages

  Tarasov, Kirill V ^a   Tarasova, Yelena S ^a   Tam, Wai Leong ^b   Riordon, Daniel R ^a   Elliott, Steven T ^c   Kania, Gabriela ^d   Li, Jinliang ^a   Yamanaka, Satoshi ^a   Crider, David G ^a   Testa, Gianluca ^a   Li, Ronald A ^e   Lim, Bing ^b,f   Stewart, Colin L ^g   Liu, Yie ^a   Van Eyk, Jennifer E ^c   Wersto, Robert P ^a   Wobus, Anna M ^d   Boheler, Kenneth R ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LEIBNIZ INSTITUTE OF PLANT GENETICS AND CROP PLANT RESEARCH IPK   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN B MYB; RNA; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; PROTEIN C MYB;

ANEUPLOIDY; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL VIABILITY; CENTROSOME; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS SPINDLE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; POLYPLOIDY; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DEFECT; PROTEIN DEPLETION; PROTEIN FUNCTION; ANIMAL; CELL CYCLE; CYTOLOGY; GENETICS; ONCOGENE MYB; PHYSIOLOGY;

MURINAE; MUS;

ANEUPLOIDY; ANIMALS; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CHROMOSOMAL INSTABILITY; EMBRYONIC STEM CELLS; GENES, MYB; MICE; POLYPLOIDY; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYB;

EID: 49649113886     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002478     Document Type: Article

References (42)

1. Oh IH, Reddy EP 1999) The myb gene family in cell growth, differentiation and apoptosis. Oncogene. 18: 3017-3033.
2. Sala A (2005) B-MYB, a transcription factor implicated in regulating cell cycle, apoptosis and cancer. Eur J Cancer, 2005; 41: 2479-2484.
3. Ness SA (2003) Myb protein specificity: evidence of a context-specific transcription factor code. Blood Cells Mol Dis. 31: 192-200.
4. Sandberg ML, Sutton SE, Pletcher MT, Wiltshire T, Tarantino LM, et al. (2005) c-Myb and p300 regulate hematopoetic stem cell proliferation and differentiation. Dev Cell, 8: 153-166.
5. Toscani A, Mettus RV, Coupland R, Simpkins H, Litvin J, et al. (1997) Arrest of spermatogenesis and defective breast development in mice lacking A-myb Nature. 386: 713-717.
6. Davidson CJ, Tirouvanziam R, Herzenberg LA, Lipsick JS (2005) Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes. Genetics. 169: 215-229.
7. Joaquin M, Watson RJ (2003) Cell cycle regulation by the B-Myb transcription factor. Cell Mol Life Sci. 60: 2389-2401.
8. Bessa M, Saville MK, Watson RJ (2001) Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator. Oncogene. 20: 3376-3386.
9. Charrasse S, Carena I, Brondani V, Klempnauer KH, Ferrari S (2000) Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway. Oncogene. 19: 2986-2995.
10. Garcia P, Frampton J (2006).The transcription factor B-Myb is essential for S-phase progression and genomic stability in diploid and polyploid megakaryocytes. J Cell Sci. 19: 1483-1493.
11. Manak JR, Mitiku N, Lipsick JS (2002) Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability. Proc Natl Acad Sci U S A. 99: 7438-7443.
12. Manak JR, Wen H, Tran V, Andrejka L, Lipsick JS (2007) Loss of Drosophila Myb interrupts the progression of chromosome condensation. Nat Cell Biol. 9: 581-587.
13. Shepard JL, Amatruda JF, Stern HM, Subramanian A, Finkelstein D, Ziai J, et al. (2005) A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A. 102: 13194-13199.
14. Tanaka Y, Patestos NP, Maekawa T, Ishii S (1999) B-myb is required for inner cell mass formation at an early stage of development. J Biol Chem. 274: 28067-28070.
15. Iwai N, Kitajima K, Sakai K, Kimura T, Nakano T (2001) Alteration of cell adhesion and cell cycle properties of ES cells by an inducible dominant interfering Myb mutant. Oncogene. 20: 1425-1434.
16. Nakagoshi H, Kanei-Ishii C, Sawazaki T, Mizuguchi G, Ishii S (1992) Transcriptional activation of the c-myc gene by the c-myb and B-myb gene products. Oncogene. 7: 1233-1240.
17. Tashiro S, Sumi T, Oozumi N, Shimizu T, Nakamura T (2004) B-Myb-dependent regulation of c-Myc expression by cytosolic phospholipase A2. J Biol Chem. 279: 17715-17722.
18. Lang G, Gombert WM, Gould HJ (2005) A transcriptional regulatory element in the coding sequence of the human Bcl-2 gene. Immunology. 114: 25-36.
19. Nordhoff V, Hubner K, Bauer A, Orlova I, Malapetsa A, et al. (2001) Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences. Mamm Genome. 12: 309-317.
20. Snow MH, Bennett D (1978) Gastrulation in the mouse: assessment of cell populations in the epiblast of tw18/tw18 embryos. J Embryol Exp Morphol. 47: 39-52.
21. Mantel C, Guo Y, Lee MR, Kim MK, Han MK, et al. (2007) Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability. Blood. 109: 4518-4527.
22. Tarasov KV, Testa G, Tarasova YS, Kania G, Riordon DR, et al. (2008) Linkage of Pluripotent Stem Cell- Associated Transcripts to Regulatory Gene Networks. Cells Tissues Organs. 27: [Epub ahead of print].
23. Xiwa H, Miyazaki J, Smith AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet. 24: 372-376.
24. Zeineddine D, Papadimou E, Chebli K, Gineste M, Liu J, et al. (2006) Oct-3/4 dose dependently regulates specification of embryonic stem cells toward a cardiac lineage and early heart development. Dev Cell. 11: 535-546.
25. Li X, McDonnell DP (2002) The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Mol Cell Biol. 22: 3663-3673.
26. Schulert S, Horstmann S, Bartusel T, Klempnauer KH (2004) The cooperation of B-Myb with time coactivator p300 is orchestrated by cyclins A and D1. Oncogene. 23: 1392-1404.
27. Johnson LR, Johnson TK, Desler M, Luster TA, Nowling T, et al. (2002) Effects of B-Myb on gene transcription: phosphorylation-dependent activity and acetylation by p300. J Biol Chem. 277: 4088-4097.
28. Grasilli F, Salomoni P, Perrotti D. Franceschi C, Calabretta B (1999) Resistance to apoptosis in CTLL-2 cells overexpressing B-Myb is associated with B-Myb-dependent bcl-2 induction. Cancer Res. 59: 2451-2456.
29. Wobus AM, Guan K, Yang H-T, Boheler KR (2002) Embryonic stem. cells as a model to study cardiac, skeletal muscle and vascular smooth muscle cell differentiation. In: Turksen K, ed (2002) Methods Mol Biol. Totowa, New Jersey: Humana Press. pp 127-156.
30. Wobus AM, Kleppisch T, Maltsev V, Hescheler J (1994) Cardiomyocyte-like cells differentiated in vitro from embryonic carcinoma cells P19 are characterized by functional expression of adrenoceptors and Ca2+ channels. In Vitro Cell Dev Biol Anim. 30A: 425-434.
31. Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, et al. 2005) Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation. 111 11-20.
32. Tarasova YS, Riordon DR, Tarasov KV, Boheler KR (2006) In vitro differentiation of mouse ES cells to muscle cells. In: Notarianni E, Evans MJ, eds (2006) Embryonic Stem Cells. New York: Oxford University Press. pp 130-168.
33. Elliott ST, Crider DG, Garnham GP, Boheler KR, Van Eyk JE (2001) Two-dimensional gel electrophoresis database of murine RI embryonic stem cells Proteomics. 4: 3813-3832.
34. Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, et al. (2004) Rational siRNA design for RNA interference. Nat Biotechnol. 22: 326-330.
35. Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, et al. (2004) Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. 32: 936-948.
36. Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ (2004) Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature. 427: 148-154.
37. Wersto RP, Rosenthal ER, Seth PK, Eissa NT, Donahue RE (1998) Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins. J Virol. 72: 9491-9502.
38. Chew JL, Loh YH, Zhang W, Chen X, Tam WL, et al. (2005) Reciprocal transcriptional regulation of Pou5fl and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol. 25: 6031-6046.
39. Debiak M, Nikolova T, Kaina B (2004) Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations. DNA Repair (Amst). 3: 359-368.
40. Wang Y, Erdmann N, Giannone RJ, Wu J, Gomez M, et al. (2005) An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres. Proc Natl Acad Sci U S A. 102: 10256-10260.
41. Chesley A, Lundberg MS, Asai T, Xiao RP, Ohtani S, et al. (2000) The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3′-kinase. Circ Res. 87: 1172-1179.
42. Chambers I, Colby D, Robertson M, Nichols J, Lee S, et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaininng factor in embryonic stem cells. Cell. 113: 643-655.