Safety of creatine supplementation

Subcellular Biochemistry

Volumn 46, Issue , 2007, Pages 275-289

  Persky, Adam M ^a   Rawson, Eric S ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b BLOOMSBURG UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE;

ANIMAL; DIET SUPPLEMENTATION; HUMAN; REVIEW;

ANIMALS; CREATINE; DIETARY SUPPLEMENTS; HUMANS;

EID: 49649108857     PISSN: 03060225     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4020-6486-9_14     Document Type: Article

References (63)

1. Benzi, G., 2000, Is there a rationale for the use of creatine either as nutritional supplementation or drug administration in humans participating in a sport? Pharmacol. Res. 41: 255-264.
2. Branch, J.D., 2003, Effect of creatine supplementation on body composition and performance: a metaanalysis. Int. J. Sport Nutr. Exerc. Metab. 13: 198-226.
3. Charatan, F., 2001, Bayer decides to withdraw cholesterol lowering drug. BMJ 323: 359.
4. Dash, A.K., and Sawhney, A., 2002, A simple LC method with UV detection for the analysis of creatine and creatinine and its application to several creatine formulations. J. Pharm. Biomed. Anal. 29: 939-945.
5. Earnest, C.P., Almada, A.L., and Mitchell, T.L., 1996, High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin. Sci. (London) 91: 113-118.
6. Green, A.L., Hultman, E., Macdonald, I.A., Sewell, D.A., and Greenhaff, P.L., 1996a, Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am. J. Physiol. 271: E821-E826.
7. Green, A.L., Simpson, E.J., Littlewood, J.J., Macdonald, I.A., and Greenhaff, P.L., 1996b, Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol. Scand. 158: 195-202.
8. Greenwood, M., Farris, J., Kreider, R., Greenwood, L., and Byars, A., 2000, Creatine supplementation patterns and perceived effects in select division I collegiate athletes. Clin. J. Sport Med. 10: 191-194.
9. Greenwood, M., Kreider, R.B., Greenwood, L., and Byars, A., 2003a, Cramping and injury incidence in collegiate football players are reduced by creatine supplementation. J. Athl. Train. 38: 216-219.
10. Greenwood, M., Kreider, R.B., Greenwood, L., Willoughby, D.S., and Byars, A., 2003b, The effects of creatine supplementation on cramping and injury occurrence during college baseball training and competition. J. Ex. Physiol. Online 6: 16-23.
11. Greenwood, M., Kreider, R.B., Melton, C., Rasmussen, C., Lancaster, S., Cantler, E., Milnor, P., and Almada, A., 2003c, Creatine supplementation during college football training does not increase the incidence of cramping or injury. Mol. Cell. Biochem. 244: 83-88.
12. Groeneveld, G.J., Beijer, C., Veldink, J.H., Kalmijn, S., Wokke, J.H., and van den Berg, L.H., 2005, Few adverse effects of long-term creatine supplementation in a placebo-controlled trial. Int. J. Sports Med. 26: 307-313.
13. Harris, R.C., Almada, A.L., Harris, D.B., Dunnett, M., and Hespel, P., 2004, The creatine content of Creatine Serum and the change in the plasma concentration with ingestion of a single dose. J. Sports Sci. 22: 851-857.
14. Harris, R.C., Soderlund, K., and Hultman, E., 1992, Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. (London) 83: 367-374.
15. Hile, A.M., Anderson, J.M., Fiala, K.A., Stevenson, J.H., Casa, D.J., and Maresh, C.M., 2006, Creatine supplementation and anterior compartment pressure during exercise in the heat in dehydrated men. J. Athl. Train. 41: 30-35.
16. Juhn, M.S., O'Kane, J.W., and Vinci, D.M., 1999, Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J. Am. Diet. Assoc. 99: 593-595.
17. Kamber, M., Koster, M., Kreis, R., Walker, G., Boesch, C., and Hoppeler, H., 1999, Creatine supplementation-part I: performance, clinical chemistry, and muscle volume. Med. Sci. Sports Exerc. 31: 1763-1769.
18. Kammer, R.T., 2005, Lone atrial fibrillation associated with creatine monohydrate supplementation. Pharmacotherapy 25: 762-764.
19. Kern, M., Podewils, L.J., Vukovich, M., and Buono, M.J., 2001, Physiological responses to exercise in the heat following creatine supplementation. J. Ex. Physiol. Online 4: 18-27.
20. Kilduff, L.P., Georgiades, E., James, N., Minnion, R.H., Mitchell, M., Kingsmore, D., Hadjicharlambous, M., and Pitsiladis, Y.P., 2004, The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans. Int. J. Sport Nutr. Exerc. Metab. 14: 443-460.
21. Koshy, K.M., Griswold, E., and Schneeberger, E.E., 1999, Interstitial nephritis in a patient taking creatine. N. Engl. J. Med. 340: 814-815.
22. Koszalka, T.R., Andrew, C.L., and Brent, R.L., 1972, Effect of insulin on the uptake of creatine-1-14C by skeletal muscle in normal and X-irradiated rats. Proc. Soc. Exp. Biol. Med. 139: 1265-1271.
23. Kreider, R.B., 2003, Species-specific responses to creatine supplementation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285: R725-R726.
24. Kreider, R.B., Melton, C., Rasmussen, C.J., Greenwood, M., Lancaster, S., Cantler, E.C., Milnor, P., and Almada, A.L., 2003, Long-term creatine supplementation does not significantly affect clinical markers of health in athletes. Mol. Cell. Biochem. 244: 95-104.
25. Kuklo, T.R., Tis, J.E., Moores, L.K., and Schaefer, R.A., 2000, Fatal rhabdomyolysis with bilateral gluteal, thigh, and leg compartment syndrome after the Army Physical Fitness Test. A case report. Am. J. Sports Med. 28: 112-116.
26. Louis, M., Lebacq, J., Poortmans, J.R., Belpaire-Dethiou, M.C., Devogelaer, J.P., Van Hecke, P., Goubel, F., and Francaux, M., 2003, Beneficial effects of creatine supplementation in dystrophic patients. Muscle Nerve 27: 604-610.
27. Mayhew, D.L., Mayhew, J.L., and Ware, J.S., 2002, Effects of long-term creatine supplementation on liver and kidney functions in American college football players. Int. J. Sport Nutr. Exerc. Metab. 12: 453-460.
28. Mendel, R.W., Blegen, M., Cheatham, C., Antonio, J., and Ziegenfuss, T., 2005, Effects of creatine on thermoregulatory responses while exercising in the heat. Nutrition 21: 301-307.
29. Mendes, R.R., Pires, I., Oliveira, A., and Tirapegui, J., 2004, Effects of creatine supplementation on the performance and body composition of competitive swimmers. J. Nutr. Biochem. 15: 473-478.
30. Mihic, S., MacDonald, J.R., McKenzie, S., and Tarnopolsky, M.A., 2000, Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med. Sci. Sports Exerc. 32: 291-296.
31. Parise, G., Mihic, S., MacLennan, D., Yarasheski, K.E., and Tarnopolsky, M.A., 2001, Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis. J. Appl. Physiol. 91: 1041-1047.
32. Persky, A.M., Hochhaus, G., and Brazeau, G.A., 2003, Validation of a simple liquid chromatography assay for creatine suitable for pharmacokinetic applications, determination of plasma protein binding and verification of percent labeled claim of various creatine products. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 794: 157-165.
33. Poortmans, J.R., Auquier, H., Renaut, V., Durussel, A., Saugy, M., and Brisson, G.R., 1997, Effect of short-term creatine supplementation on renal responses in men. Eur. J. Appl. Physiol. Occup. Physiol. 76: 566-567.
34. Poortmans, J.R., and Francaux, M., 1999, Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med. Sci. Sports Exerc. 31: 1108-1110.
35. Poortmans, J.R., Kumps, A., Duez, P., Fofonka, A., Carpentier, A., and Francaux, M., 2005, Effect of oral creatine supplementation on urinary methylamine, formaldehyde, and formate. Med. Sci. Sports Exerc. 37: 1717-1720.
36. Powers, M.E., Arnold, B.L., Weltman, A.L., Perrin, D.H., Mistry, D., Kahler, D.M., Kraemer, W., and Volek, J., 2003, Creatine supplementation increases total body water without altering fluid distribution. J. Athl. Train. 38: 44-50.
37. Preen, D., Dawson, B., Goodman, C., Beilby, J., and Ching, S., 2003, Creatine supplementation: a comparison of loading and maintenance protocols on creatine uptake by human skeletal muscle. Int. J. Sport Nutr. Exerc. Metab. 13: 97-111.
38. Pritchard, N.R., and Kalra, P.A., 1998, Renal dysfunction accompanying oral creatine supplements. Lancet 351: 1252-1253.
39. Rawson, E.S., Conti, M.P., and Miles, M.P., 2007, Creatine supplementation does not reduce muscle damage or enhance recovery from resistance exercise. J. Strength Cond. Res., in press.
40. Rawson, E.S., Gunn, B., and Clarkson, P.M., 2001, The effects of creatine supplementation on exerciseinduced muscle damage. J. Strength Cond. Res. 15: 178-184.
41. Revai, T., Sapi, Z., Benedek, S., Kovacs, A., Kaszas, I., Viranyi, M., and Winkler, G., 2003, [Severe nephrotic syndrome in a young man taking anabolic steroid and creatine long term]. Orv. Hetil. 144: 2425-2427.
42. Robinson, S.J., 2000, Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J. Am. Board Fam. Pract. 13: 134-137.
43. Robinson, T.M., Sewell, D.A., Casey, A., Steenge, G., and Greenhaff, P.L., 2000, Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br. J. Sports Med. 34: 284-288.
44. Saks, V.A., Stepanov, V., Jaliashvili, I.V., Konorev, E.A., Kryzkanovsky, S.A., Strumia, E., and Clark, J.F.S.D., 1996, Molecular and cellular mechanisms of action for the cardioprotective and therapeutic role of creatine phosphate. In: Conway, M.A. and Clark, J.F. (eds.), Creatine and Creatine Phosphate: Scientific and Clinical Perspectives. Academic Press, San Diego.
45. Saks, V.A., and Strumia, E., 1993, Phosphocreatine: molecular and cellular aspects of the mechanism of cardioprotective action. Curr. Ther. Res. 53: 565-598.
46. Sandhu, R.S., Como, J.J., Scalea, T.S., and Betts, J.M., 2002, Renal failure and exercise-induced rhabdomyolysis in patients taking performance-enhancing compounds. J. Trauma 53: 761-764.
47. Santos, R.V., Bassit, R.A., Caperuto, E.C., and Costa Rosa, L.F., 2004, The effect of creatine supplementation upon inflammatory and muscle soreness markers after a 30km race. Life Sci. 75: 1917-1924.
48. Schedel, J.M., Tanaka, H., Kiyonaga, A., Shindo, M., and Schutz, Y., 1999, Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations. Life Sci. 65: 2463-2470.
49. Schilling, B.K., Stone, M.H., Utter, A., Kearney, J.T., Johnson, M., Coglianese, R., Smith, L., O'Bryant, H.S., Fry, A.C., Starks, M., Keith, R., and Stone, M.E., 2001, Creatine supplementation and health variables: a retrospective study. Med. Sci. Sports Exerc. 33: 183-188.
50. Schroder, H., Terrados, N., and Tramullas, A., 2005, Risk assessment of the potential side effects of long-term creatine supplementation in team sport athletes. Eur. J. Nutr. 44: 255-261.
51. Sheth, N.P., Sennett, B., and Berns, J.S., 2006, Rhabdomyolysis and acute renal failure following arthroscopic knee surgery in a college football player taking creatine supplements. Clin. Nephrol. 65: 134-137.
52. Skare, O.C., Skadberg, and Wisnes, A.R., 2001, Creatine supplementation improves sprint performance in male sprinters. Scand. J. Med. Sci. Sports 11: 96-102.
53. Tarnopolsky, M., Mahoney, D., Thompson, T., Naylor, H., and Doherty, T.J., 2004, Creatine monohydrate supplementation does not increase muscle strength, lean body mass, or muscle phosphocreatine in patients with myotonic dystrophy type 1. Muscle Nerve 29: 51-58.
54. Tarnopolsky, M.A., Bourgeois, J.M., Snow, R., Keys, S., Roy, B.D., Kwiecien, J.M., and Turnbull, J., 2003, Histological assessment of intermediate- and long-term creatine monohydrate supplementation in mice and rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285: R762-R769.
55. Tarnopolsky, M.A., and Raha, S., 2005, Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options. Med. Sci. Sports Exerc. 37: 2086-2093.
56. Tran, T.T., Dai, W., and Sarkar, H.K., 2000, Cyclosporin A inhibits creatine uptake by altering surface expression of the creatine transporter. J. Biol. Chem. 275: 35708-35714.
57. Vogel, R.A., Webster, M.J., Erdmann, L.D., and Clark, R.D., 2000, Creatine supplementation: Effect on supramaximal exercise performance at two levels of acute hypohydration. J. Strength Cond. Res. 14: 214-219.
58. Volek, J.S., Duncan, N.D., Mazzetti, S.A., Putukian, M., Gomez, A.L., and Kraemer, W.J., 2000, No effect of heavy resistance training and creatine supplementation on blood lipids. Int. J. Sport Nutr. Exerc. Metab. 10: 144-156.
59. Volek, J.S., Mazzetti, S.A., Farquhar, W.B., Barnes, B.R., Gomez, A.L., and Kraemer, W.J., 2001, Physiological responses to short-term exercise in the heat after creatine loading. Med. Sci. Sports Exerc. 33: 1101-1108.
60. Walker, J.B., and Hannan, J.K., 1976, Creatine biosynthesis during embryonic development. False feedback suppression of liver amidinotransferase by N-acetimidoylsarcosine and 1-carboxymethyl-2- iminoimidazolidine (cyclocreatine). Biochemistry 15: 2519-2522.
61. Warren, G.L., Fennessy, J.M., and Millard-Stafford, M.L., 2000, Strength loss after eccentric contractions is unaffected by creatine supplementation. J. Appl. Physiol. 89: 557-562.
62. Watson, G., Casa, D.J., Fiala, K.A., Hile, A., Roti, M.W., Healey, J.C., Armstrong, L.E., and Maresh, C.M., 2006, Creatine use and exercise heat tolerance in dehydrated men. J. Athl. Train. 41: 18-29.
63. Yu, P.H., and Deng, Y., 2000, Potential cytotoxic effect of chronic administration of creatine, a nutrition supplement to augment athletic performance. Med. Hypotheses 54: 726-728.