A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge

PLoS ONE

Volumn 3, Issue 6, 2008, Pages

  Pechous, Roger D ^a   McCarthy, Travis R ^a   Mohapatra, Nrusingh P ^b   Soni, Shilpa ^b   Penoske, Renee M ^a   Salzman, Nita H ^a   Frank, Dara W ^a   Gunn, John S ^b   Zahrt, Thomas C ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; LIVE VACCINE; PURINE; PURINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUXOTROPHIC MUTANT; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FRANCISELLA TULARENSIS; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG INJURY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; STRAIN DIFFERENCE; SURVIVAL RATE; VACCINATION; WILD TYPE; ANIMAL; CELL LINE; GENETICS; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; LUNG; MICROBIOLOGY; MUTATION; PATHOGENICITY; VIRULENCE;

FRANCISELLA; FRANCISELLA TULARENSIS; MUS; NEGIBACTERIA;

ADMINISTRATION, INTRANASAL; ANIMALS; BACTERIAL VACCINES; CELL LINE; FRANCISELLA TULARENSIS; HUMANS; LUNG; MACROPHAGES; MICE; MUTATION; PURINES; VIRULENCE;

EID: 49649100202     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002487     Document Type: Article

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