Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation

Infection and Immunity

Volumn 75, Issue 2, 2007, Pages 1034-1039

  Hall, Joshua D ^a   Craven, Robin R ^a   Fuller, James R ^a   Pickles, Raymond J ^a   Kawula, Thomas H ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; CELL INTERACTION; DENDRITIC CELL; FRANCISELLA TULARENSIS; IN VIVO STUDY; LUNG ALVEOLUS CELL TYPE 2; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TULAREMIA;

ANIMALS; CELL LINE; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; FRANCISELLA TULARENSIS; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; PULMONARY ALVEOLI; TULAREMIA;

EID: 33846797926     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01254-06     Document Type: Article

References (18)

1. Anthony, L. D., R. D. Burke, and F. E. Nano. 1991. Growth of Francisella spp. in rodent macrophages. Infect. Immun. 59:3291-3296.
2. Baron, G. S., and F. E. Nano. 1998. MglA and MglB are required for the intramacrophage growth of Francisella novicida. Mol. Microbiol. 29:247-259.
3. Beers, M. F., and S. Mulugeta. 2005. Surfactant protein C biosynthesis and its emerging role in conformational lung disease. Annu. Rev. Physiol. 67:663-696.
4. Bolger, C. E., C. A. Forestal, J. K. Italo, J. L. Benach, and M. B. Furie. 2005. The live vaccine strain of Francisella tularensis replicates in human and murine macrophages but induces only the human cells to secrete proinflammatory cytokines. J. Leukoc. Biol. 77:893-897.
5. Bosio, C. M., and S. W. Dow. 2005. Francisella tularensis induces aberrant activation of pulmonary dendritic cells. J. Immunol. 175:6792-6801.
6. Centers for Disease Control and Prevention. 2005. Tularemia transmitted by insect bites - Wyoming, 2001-2003. Morb. Mortal. Wkly. Rep. 54:170-173.
7. Conlan, J. W., W. Chen, H. Shen, A. Webb, and R. KuoLee. 2003. Experimental tularemia in mice challenged by aerosol or intradermally with virulent strains of Francisella tularensis: bacteriologic and histopathologic studies. Microb. Pathog. 34:239-248.
8. Conlan, J. W., and R. J. North. 1992. Early pathogenesis of infection in the liver with the facultative intracellular bacteria Listeria monocytogenes, Francisella tularensis, and Salmonella typhimurium involves lysis of infected hepatocytes by leukocytes. Infect. Immun. 60:5164-5171.
9. Dennis, D. T., T. V. Inglesby, D. A. Henderson, J. G. Bartlett, M. S. Ascher, E. Eitzen, A. D. Fine, A. M. Friedlander, J. Hauer, M. Layton, S. R. Lillibridge, J. E. McDade, M. T. Osterholm, T. O'Toole, G. Parker, T. M. Perl, P. K. Russell, and K. Tonat. 2001. Tularemia as a biological weapon: medical and public health management. JAMA 285:2763-2773.
10. Ellis, J., P. C. Oyston, M. Green, and R. W. Titball. 2002. Tularemia. Clin. Microbiol. Rev. 15:631-646.
11. Golovliov, I., A. Sjostedt, A. Mokrievich, and V. Pavlov. 2003. A method for allelic replacement in Francisella tularensis. FEMS Microbiol. Lett. 222:273-280.
12. Gray, C. G., S. C. Cowley, K. K. Cheung, and F. E. Nano. 2002. The identification of five genetic loci of Francisella novicida associated with intracellular growth. FEMS Microbiol. Lett. 215:53-56.
13. Guttentag, S. H., M. F. Beers, B. M. Bieler, and P. L. Ballard. 1998. Surfactant protein B processing in human fetal lung. Am. J. Physiol. 275:L559-L566.
14. Lauriano, C. M., J. R. Barker, F. E. Nano, B. P. Arulanandam, and K. E. Klose. 2003. Allelic exchange in Francisella tularensis using PCR products. FEMS Microbiol. Lett. 229:195-202.
15. Lauriano, C. M., J. R. Barker, S. S. Yoon, F. E. Nano, B. P. Arulanandam, D. J. Hassett, and K. E. Klose. 2004. MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival. Proc. Natl. Acad. Sci. USA 101:4246-4249.
16. Saslaw, S., H. T. Eigelsbach, J. A. Prior, H. E. Wilson, and S. Carhart. 1961. Tularemia vaccine study. II. Respiratory challenge. Arch. Intern. Med. 107:702-714.
17. Saslaw, S., H. T. Eigelsbach, H. E. Wilson, J. A. Prior, and S. Carhart. 1961. Tularemia vaccine study. I. Intracutaneous challenge. Arch. Intern. Med. 107:689-701.
18. Titball, R. W., A. Jobansson, and M. Forsman. 2003. Will the enigma of Francisella tularensis virulence soon be solved? Trends Microbiol. 11:118-123.