Effect of antioxidants l-ascorbic acid and alpha-tocopherol supplementation in nickel exposed hyperglycemic rats

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 19, Issue 2, 2008, Pages 89-102

  Tikare, Swati N ^a   Gupta, Amrita Das ^a   Dhundasi, Salim A ^a   Das, Kusal K ^a  

^a AL AMEEN MEDICAL COLLEGE   (India)

Author keywords

hyperglycemia; nickel sulfate; vitamin C; vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; GLUCAGON; GLUCOSE; GLYCOGEN; NICKEL SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCAGON RELEASE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLYCOGENOLYSIS; HYPERGLYCEMIA; LIVER; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS; RAT; TREATMENT OUTCOME;

ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BLOOD GLUCOSE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HYPERGLYCEMIA; LIVER GLYCOGEN; MALE; NICKEL; RATS; RATS, WISTAR;

EID: 49549100937     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/JBCPP.2008.19.2.89     Document Type: Article

References (38)

1. Nielsen, FH, Shuler, TR, Mcleod, TG, Zimmerman, TJ. Nickel influences iron metabolism through physiologic, pharmacologic and toxicologic mechanisms in rats. J Nutr 1984;114:1280-8.
2. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Nickel. U.S. Department of Health and Human Services, Public Health Service, ATSDR. Atlanta, Georgia, USA: U.S. Government Printing Office 2003; 5–16.
3. National Institute of Occupational Safety and Health, Occupational Safety and Health Administration. Pocket guide to chemical hazards, Wahington DC, USA: U.S. NIOSH/OSHA (Publication No.85.114), 1985.
4. Das, KK, Dasgupta, S. Studies on the role of nickel in the metabolism of ascorbic acid and cholesterol in experimental animals. Ind J Physiol Allied Sci 1998;52:58–62.
5. Onkelinx, C, Becker, J, Sunderman, FW Jr. Compartmental analysis of the metabolism of Ni (II) in rats and rabbits. Res Commun Chem Pathol Pharmacol 1973;6:663.
6. Das, KK, Dasgupta, S. Alteration of testicular biochemistry during protein restriction in nickel treated rats. Biol Trace Elem Res 1997;60: 243-8
7. Das, KK, Dasgupta, S. Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction. Environ Health Perspect 2002; 110:923-6.
8. Whanger, PD. Effect of dietary nickel on enzyme activities and mineral content in rats. Toxicol Appl Pharmacol 1973;25:323-31.
9. Dieter, MP, Jameson, CW, Tucker, AN, Luster, MI, French, JE, Hong, HL et al. Evaluation of tissue deposition myelopoietic and immunologic responses in mice after long term exposure to nickel sulfate in drinking water. J Toxicol Environ Health 1988;24:357-72.
10. Horak, E, Zygowicz, ER, Tarabishy, R, Mitchell, JM, Sunderman, FW Jr. Effects of nickel chloride and nickel carbonyl upon glucose metabolism in rats. Ann Clin Lab Sci 1978;8(6):476-82.
11. Cartana, J, Arola, L. Nickel-induced hyperglycaemia: the role of insulin and glucagon. Toxicology 1992;71 (1-2): 181-92.
12. Gupta, S, Ahmad, N, Husain, MM, Srivastava, RC. Involvement of nitric oxide in nickel-induced hyperglycemia in rats. Nitric Oxide 2000;4(2): 129-38.
13. Das, KK, Gupta, AD, Dhundasi, SA, et al. Effect of L-ascorbic acid on nickel-induced alterations in serum lipid profiles and liver histopathology of rats. J Basic Clin Physiol Pharmacol 2006;17:29–44.
14. Stoho, SJ, Bagchi, D. Oxidative mechanism in the toxicity of metal ions. Free Radic Biol Med 1995;18:321-36.
15. Salnikow, K, Donald, SP, Bruick, RK, Zhitkovich, A, Phang, JM, Kasprzak, KS. Depletion of intracellular ascorbate by the carcinogenic metal nickel and cobalt results in the induction of hypoxic stress. J Biol Chem 2004;279(39):40337-44.
16. Uusitalo, L, Knip, M, Kenward, MG, Alfthan, G, Sundvall, J, Aro, A, et al. Ascorbic acid and alpha tocopherol antioxidant status of type 2 diabetes mellitus patients seen in Lagos. Niger Postgrad Med J 2005;12(3):155-7.
17. Muis, MJ, Stolk, RP, Princen, HM, Van Dam, PS, Dikkeschei, LD, Grobbee, DE, et al. Alpha-tocopherol levels in plasma in new-onset, insulin-dependent diabetes mellitus. Eur J Intern Med 2004; 15(6):371-4.
18. Salonen, JT, Nyyssonen, K, Tuomainen, TP, Mäenpää, PH, Korpela, H, Kaplan, GA, et al. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. BMJ 1995;311(7013): 1124-7.
19. Kataja-Tuomola, M, Sundell, JR, Männisto, S, Virtanen, MJ, Kontto, J, Albanes, D, Virtamo, J. Effect of alpha-tocopherol and beta-carotene supplementation on the incidence of type 2 diabetes. Diabetologia. 2008;51(1):47–53.
20. Uusitalo, L, Knip, M, Kenward, MG, Alfthan, G, Sundvall, J, Aro, A, et al. Childhood Diabetes in Finland Study Group. Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children. J Pediatr Endocrinol Metab 2005;18(12): 1409-16.
21. Peerapatdit, T, Likidlilid, A, Patchanans, N, Somkasetrin A. Antioxidant status and lipid peroxidation end products in patients of type 1 diabetes mellitus. J Med Assoc Thai 2006;89 Suppl 5:S141-6.
22. Sridevi, S, Chary, MG, Krishna, DR, Diwan, PV. Pharmacodynamic evaluation of transdermal drug delivery system of glibenclamide in rats. Indian J Pharmacol 2000;32:309-12.
23. Bordes, E, Papillion, VV. Myocardial change induced by nickel and in association with cadmium. Rev Ig Bacteriol Virusal Parazitol Epidemol Pneumotizol 1983;32:51-6.
24. Husain, K, Sugendran, K, Pant, SC, Sharma, VP, Vijayaraghavan, R. Biochemical and pathological changes in response to hyperoxia and protection by antioxidants in rats. Indian J Physiol Pharmacol 1992; 36(2):97–100.
25. Kadkhodaee, M, Khastar, H, Faghihi, M, Ghaznavi, R, Zahmatkesh, M. Effects of co-supplementation of vitamins E and C on gentamicin-induced nephrotoxicity in rat. Exp Physiol 2005 90(4):571-6.
26. Declaration of Helsinki (1964). Amended by World Medical Assembly, Venice, Italy, 1983. Br Med J 1996;313:1448-9.
27. Trinder, P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 1969;6:24-7.
28. Patrick, SJ, Jelliffe and Stuart, KL. The hepatic glycogen content in acute toxic hypoglycemia. J Trop Pediatr 1955;1:88–89.
29. Steel, RGD, Torrie, JH. In: Principles and Procedures of Statistics, New York, NY, USA: McGraw-Hill, 1960;99–131.
30. Alverez, C, Blade, C, Catana, J. Alpha 2 adrenergic blockade prevents hyperglycemia and hepatic glutathione depletion in nickel-injected rats. Toxicol Appl Pharmacol 1993; 121 (1): 112-7
31. Liang, WJ, Johnson, D, Jarvis, SM. Vitamin C transport systems of mammalian cells. Mol Membr Biol 2001;18(1):87–95.
32. Will, JC, Byers, T: Does diabetes mellitus increase the requirement for vitamin C? Nutr Rev 1996;54:193–202.
33. Cunningham, JJ. The glucose/insulin system and vitamin C: implications in insulin-dependent diabetes mellitus. J Am Coll Nutr 1998;17(2): 105-8.
34. Salnikow, K, Kasprzak, KS. Ascorbate depletion: A critical step in nickel carcinogenesis. Environ Health Perspect 2005;113(5):577-84.
35. Abdel-Wahab, YH, O’Harte, FP, Mooney, MH, Barnett, CR, Flatt, PR. Vitamin C supplementation decreases insulin glycation and improves glucose homeostasis in obese hyperglycemic (ob/ob) mice. Metabolism 2002;51(4):514-7.
36. Ihara, Y, Yamada, Y, Toyokuni, S, Miyawaki, K, Ban, N, Adachi, T, et al. Antioxidant alpha-tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes. FEBS Lett 2000;473(1):24-6.
37. Bulger, EM, Helton, WS. Nutrient antioxidants in gastrointestinal disease. Nutrition 1998;14:513-20.
38. Johnston, CS, Yen, MT. Megadose of vitamin C delays insulin response to a glucose challenge in normoglycemic adults. Am J Clin Nutr 1994, 60:735-8.