Simultaneous determination of 6,7-dimethylesculetin and geniposide in rat plasma and its application to pharmacokinetic studies of Yin Chen Hao Tang preparation

Arzneimittel-Forschung/Drug Research

Volumn 58, Issue 7, 2008, Pages 336-341

  Wang, Xijun ^a   Lv, Haitao ^a   Sun, Hui ^a   Sun, Wenjun ^a   Liu, Lian ^a   Wang, Ping ^a   Cao, Hongxin ^b  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

6,7 dimethylesculetin, high performance liquid chromatography, pharmacokinetics, rat; CAS 120 08 1; CAS 24512 63 8; Geniposide, high performance liquid chromatography, pharmacokinetics, rat; Yin Chen Hao Tang preparation, pharmacokinetics

Indexed keywords

ARTEMISIA CAPILLARIS EXTRACT; CHINESE DRUG; GARDENIA JASMINOIDES EXTRACT; GENIPOSIDE; RHEUM OFFICINALE EXTRACT; SCOPARONE; YIN CHEN HAO TANG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CHINESE MEDICINE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; SOLID PHASE EXTRACTION;

EID: 49449119081     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296516     Document Type: Article

References (24)

1. Li Q, Jia Y, Sun LX, Xu L, Tong L, Shen ZD et al. High-Performance Liquid Chromatographic Method for Isofraxidin in Rat Plasma. Chromatographia 2006;3:249-253.
2. Feng SL, Hu FD, Zhao JX, Liu X, Li Y. Determination of eleutheroside E and eleutheroside B in rat plasma and tissue by high-performance liquid chromatography using solid-phase extraction and photodiode array detection. J Pharm Biopharm. 2006;62:315-320.
3. Wang XJ, Sun H, Fan YL, Li LJ, Makino T, Kano Y. Analysis and bioactive evaluation of the compounds absorbed into blood after oral administration of the extracts of Vaccinium vitis-idaea in rat. Biol Pharm Bull. 2005;28:1106-1108.
4. Zhao YL, Wang XY, Zhao YC, Gao XX, Bi KS, Yu ZG. HPLC Determination and Pharmacokinetic Study of Homoeriodictyol-7-O-β-D-glucopyranoside in Rat Plasma and Tissues. Biol Pharm Bull. 2007;30:617-620.
5. Shao F, Wang GJ, Xie HT, Zhu XY, Sun JG, Jiye A . Pharmacokinetic Study of Triptolide, a Constituent of Immunosuppressive Chinese Herb Medicine, in Rats. Biol Pharm Bull. 2007;30:702-707.
6. Makino T, Inagaki T, Komatsu K, Kano Y. Pharmacokinetic interactions between Japanese traditional kampo medicine and modern medicine (IV)-Effect of Kamisyoyosan and Tokisyakuyakusan on the pharmacokinetics of etizolam in rats. Biol Pharm Bull. 2005;28:280-284.
7. Yoshioka M, Ohnishi N, Sone N, Egami S, Takara K, Yokoyama T et al. Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. III. Effects of Ginkgo biloba Leaf Extract on the Pharmacokinetics of Nifedipine in Rats. Biol Pharm Bull 2004;27:2042-2045.
8. Arai M, Yokosuka O, Fukai K, Kanda T, Kojima H, Kawai S et al. A case of severe acute hepatitis of unknown etiology treated with the Chinese herbal medicine Inchinko-to. Hepatol Res. 2004;28 :161-165.
9. Imanishi Y, Maeda N, Otogawa K, Seki S, Matsui H, Kawada N et al. Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats. J. Hepatol. 2004;41:242-250.
10. Inao M, Mochida S, Matsui A, Eguchi Y, Yulutuz Y, Wang YH et al. Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis. J. Hepatol. 2004;41:584-591.
11. Sakaida I, Tsuchiya M, Kawaguchi K, Kimura T, Terai S, Okita K. Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme altered lesions in rat liver cirrhosis induced by a choline-deficient Lamino acid-defined diet. J Hepatol. 2003;38:762-769.
12. Chang YC, Chou FR Huang HP, Hsu JD, Wang CJ. Inhibition of cell cycle progression by penta-acetyl geniposide in rat C6 glioma cells. Toxicol Appl Pharmacol. 2004;198:11-20.
13. Zhang LM, He KZ, Ren ZJ, Pu Q. Biochemical mechanism of hepaticprotective effect of Geniposide on liver injured mice induced by CCL4. Chin J Appl Environ Biol. 2005;11: 669-672.
14. Kano Y, Wang XJ, Junko S, Reiko M. Pharmacological properties of galenical prepration (XIX) Pharmacokinetics study of 6,7-dimethylesculetin in rats. J Trad Med. 1994;11:176-180.
15. Wang XJ, Li TL, Sun H. Hepatic protection of 6,7-dimethylesculetin: constituents absorbed into blood of Yinchenhaotang and Yinchenhaotang. Chin Pharmacol Bull. 2004;20: 239-240.
16. Wang XJ, Sun H, Hua YS, Komatsu K. Studies on the distribution of 3H-Dimethylesculetin and its excretion in rats. J Natural Medicines. 1999;63:101-104.
17. Wang Q, Yu ZG, Xu S. Research on the pharmacokinetic parameters of 6,7-dimethoxycoumarin after oral administration of Yinchenhao and its decoction. Zhongguo Zhong Cheng Yao. 2003;25:182-185.
18. Yu ZG, Bi KS, Wang Q. The study on main metabolites of 6,7-dimethylesculetin in rats body. World Sci Technol Mod Trad Chin Med. 2003;5:40-45.
19. Xu L, Zhang L, Li Q, Li XQ, Chen XH, Bi KS. Determination of Geniposide in Rats Plasma. Application to Pharmacokinetic Studies of Sendeng-4 Decoction. Chromatographia. 2006;63:9-10.
20. Ye G, Zhu HY, Zhao HL, Xu B, Huang CG. HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction. Biomed Chromatogr. 2005;20:743-747.
21. Tseng TY, Tsai TH. Measurement of unbound geniposide in blood, liver, brain and bile of anesthetized rats: an application of pharmacokinetic study and its influence by the acupuncture. Anal Chem Acta. 2004;517:47-52.
22. Xia SX, Zhang YL, Zhang H, Bao YL, Xiang SJ, Li XH. Determination of geniposide in rat plasma and its pharmacokinetics. Zhongguo Zhong Yi Yao Xue Kan. 2004;22:1088-1089.
23. Zhang ZJ. Shanghanlun. Beijing: Renmin Weisheng Publisher; 2005. p.8.
24. Han GZ. Pharmacokinetics of Chinese traditional and herbal drugs. Beijing: China Medicine and Science Publisher; 1999.