HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction

Biomedical Chromatography

Volumn 20, Issue 8, 2006, Pages 743-747

  Ye, Guan ^a   Zhu, Hai Yan ^a   Zhao, Hao Long ^a   Xu, Bo ^a   Huang, Cheng Gang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Geniposide; HPLC; SPE; Yin Zhi Ku decoction

Indexed keywords

BODY FLUIDS; ORGANIC SOLVENTS; PHARMACOKINETICS; PHASE SEPARATION; RATS;

GENIPOSIDE; HPLC; HPLC METHOD; MEDICINAL PREPARATION; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PRE-CONCENTRATION; RAT SERUM; SOLID-PHASE EXTRACTION; YIN-ZHI-KU DECOCTION;

KURCHATOVIUM;

ACETONITRILE; ARTEMISIA SCOPARIA EXTRACT; GARDENIA EXTRACT; GENIPOSIDE; HERBACEOUS AGENT; PAEONIFLORIN; SOLVENT; SOPHORA FLAVESCENS EXTRACT; UNCLASSIFIED DRUG; WATER;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CHINESE MEDICINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG ISOLATION; DRUG METABOLISM; DRUG STRUCTURE; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RADIATION DETECTION; RAT; REPRODUCIBILITY; SOLID PHASE EXTRACTION; STANDARD; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 33746998922     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.590     Document Type: Article

References (13)

1. Cheng YY, Chan YS, Tia KF and Chang HM. Effect of geniposide on acute jaundice in rats caused by anit poisoning. Acta Pharmaceutica Sinica 1986; 7(1): 69-72.
2. Harada CM, Tenmyo N, Aburada M and Endo T. Pharmacological studies of gardeniae fructus I. Effects of geniposide and genipin on the biloary excretion, the gastric juice secretion, and the gastric contraction, and other pharmacological actions. Yakugaku Zasshi 1974; 94: 157-162.
3. Hu HB and Ni QY. TLC-densitometric determination of geniposide in Zhizi and Yueju Wan. Journal of China Pharmaceutical University 1989; 20(3): 179-180.
4. Masanori M, Sakae A and Yukio O. Determination of geniposide, gardenoside, and related iridoid compounds by reversed-phase high-performance liqudi chromatography. Journal of Chromatography 1986; 357(2): 293-300.
5. Masanori M, Sakae A and Yukio O. Structural transfromation of geniposide, gardenoside, and related compounds in rat gastrointestinal contents. Planta Medica 1988; 54(6): 556-557.
6. Toshiyuki O, Kazuhiko S, Tsuguchika Y, Tong YY, Zhang G and Chen YH. Determination of geniposide, gardenoside, geniposidic acid and genipin-1-□-gentiobioside in Gardenia jasminoides by high-performance liqudi chromatography. Journal of Chromatography 1988; 455: 410-414.
7. Tsai TH, Westly J, Lee TF and Chen CF. Identification and determination of geniposide, genipin, gardenoside, and geniposidic acid from herbs by HPLC/photodiode-array detection. Jounal of Liquid Chromatography 1994; 17(10): 2199-2205.
8. Tseng TY and Tsai TH. Measurement of unbound geniposide in blood, liver, brain and bile of anesthetized rats: an application of pharmacokinetic study and its influence on acupuncture. Analytica Chimica Acta 2004; 517: 47-52.
9. Ueno K, Takeda Y, Iwasaki Y and Yoshizaki F. Simultaneous estimation of geniposide and genipin in mouse plasma using high-performance liquid chromatography. Analytical Sciences 2001; 17(10): 1237-1239.
10. Yang JH and Lee NH. Skin permeation and anti-inflammatory effects of hydrolyzed products of gardeniae fructus extracts. Yakche Hakhoechi 2004; 34(2): 115-123.
11. Yim JS, Kim YS, Moon SK, Chao KH, Bae HS, Kim JJ, Park EK and Kim DH. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biological and Pharmaceutical Bulletin 2004; 27(10): 1580-1583.
12. Yoshinobu A and Youichi K. Simultaneous determination of geniposide, geniposidic acid and gardenoside in gadenia fruit by high-performance liqudi chromatography. Bunseki Kagaku 1986; 35(3): 215-218.
13. Yukio K, Masao H, Teruaki A, Kyoichi K and Tsuneo N. Formation of nitrogen-containing metabolites from geniposide and gardenoside by human intestinal bacteria. Planta Medica 1991; 57(6): 536-542.