The nitrite anion binds to human hemoglobin via the uncommon O-nitrito mode

Biochemistry

Volumn 47, Issue 32, 2008, Pages 8247-8249

  Yi, Jun ^a   Safo, Martin K ^b   Richter Addo, George B ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHLORINE COMPOUNDS; HEMOGLOBIN; LIGANDS; NEGATIVE IONS; NITRIC OXIDE;

BINDING MODES; HUMAN HEMOGLOBIN; NITRIC OXIDES; NITRITE ANION; NITRITE REDUCTASE; STRUCTURAL INFORMATIONS;

CRYSTAL STRUCTURE;

HEMOGLOBIN; NITRITE;

ALPHA CHAIN; ARTICLE; BETA CHAIN; CHEMICAL BINDING; COMPLEX FORMATION; CONFORMATION; CRYSTAL STRUCTURE; PRIORITY JOURNAL;

ADULT; ANIONS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HEMOGLOBINS; HUMANS; NITRITES; PROTEIN BINDING;

EID: 49449116592     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801015c     Document Type: Article

References (25)

1. Braida, W., and Ong, S. K. (2000) Decomposition of Nitrite Under Various pH and Aeration Conditions. Water, Air, Soil Pollut. 118, 13-26.
2. Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., III, Kelm, M., Wink, D. A., Espey, M. G., Oldfield, E. H., Pluta, R. M., Freeman, B. A., Lancaster, J. R., Jr., Feelisch, M., and Lundberg, J. O. (2005) The Emerging Biology of the Nitrite Anion. Nat. Chem. Biol. 1, 308-314. [Erratum (2006) 2 (2), 110].
3. Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., and Pater, D. (1981) Kinetics and Mechanism of the Oxidation of Human Deoxyhemoglobin by Nitrites. J. Biol. Chem. 256, 12393-12398.
4. Sibmooh, N., Piknova, B., Rizzatti, F., and Schechter, A. N. (2008) Oxidation of Iron-nitrosyl-hemoglobin by Dehydroascorbic Acid Releases Nitric Oxide to Form Nitrite in Human Erythrocytes. Biochemistry 47, 2989-2996.
5. Nagababu, E., Ramasamy, S., Abernethy, D. R., and Rifkind, J. M. (2003) Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction. J. Biol. Chem. 278, 46349-46356.
6. Grubina, R., Huang, A., Shiva, S., Joshi, M. S., Azarov, I., Basu, S., Ringwood, L. A., Jiang, A., Hogg, N., Kim-Shapiro, D. B., and Gladwin, M. T. (2007) Concerted Nitric Oxide Formation and Release from the Simultaneous Reactions of Nitrite with Deoxy-and Oxyhemoglobin. J. Biol. Chem. 282, 12916-12927.
7. Huang, K. T., Keszler, A., Patel, N., Patel, R. P., Gladwin, M. T., Kim-Shapiro, D. B., and Hogg, N. (2005) The Reaction between Nitrite and Deoxyhemoglobin. Reassessment of Reaction Kinetics and Stoichiometry. J. Biol. Chem. 280, 31126-31131.
8. Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., Huang, K. T., Shields, M., Kim-Shapiro, D. B., Schechter, A. N., Cannon, R. O., III, and Gladwin, M. T. (2003) Nitrite Reduction to Nitric Oxide by Deoxyhemoglobin Vasodilates the Human Circulation. Nat. Med. 9, 1498-1505.
9. Roche, C. J., Dantsker, D., Samuni, U., and Friedman, J. M. (2006) Nitrite Reductase Activity of Sol-Gel-encapsulated Deoxyhemoglobin: Influence of Quatenary and Tertiary Structure. J. Biol. Chem. 281, 36874-36882.
10. Williams, P. A., Fulop, V., Garman, E. F., Saunders, N. F. W., Ferguson, S. J., and Hajdu, J. (1997) Haem-ligand Switching During Catalysis in Crystals of a Nitrogen-Cycle Enzyme. Nature 389, 406-412.
11. Einsle, O., Messerschmidt, A., Huber, R., Kroneck, P. M. H., and Neese, F. (2002) Mechanism of the Six-Electron Reduction of Nitrite to Ammonia by Cytochrome c Nitrite Reductase. J. Am. Chem. Soc. 124, 11737-11745.
12. Crane, B. R., Siegel, L. M., and Getzoff, E. D. (1997) Probing the Catalytic Mechanism of Sulfite Reductase by X-ray Crystallography: Structures of the Escherichia coli Hemoprotein in Complex with Substrates, Inhibitors, Intermediates, and Products. Biochemistry 36, 12120-12137.
13. Copeland, D. M., Soares, A., West, A. H., and Richter-Addo, G. B. (2006) Crystal Structures of the Nitrite and Nitric Oxide Complexes of Horse Heart Myoglobin. J. Inorg. Biochem. 100, 1413-1425.
14. Zahran, Z. N., Chooback, L., Copeland, D. M., West, A. H., and Richter-Addo, G. B. (2008) Crystal Structures of Manganese- and Cobalt-Substituted Myoglobin in Complex with NO and Nitrite Reveal Unusual Ligand Conformations. J. Inorg. Biochem. 102, 216-233.
15. 1 Nitrite Reductase. Inorg. Chem. 43, 3715-3718.
16. Saito, T., and Takeichi, S. (1997) Experimental Studies of Methemoglobinemia due to Percutaneous Absorption of Sodium Nitrite. J. Toxicol., Clin. Toxicol. 3, 41-48.
17. Kohn, M. C., Melnick, R. L., Ye, F., and Portier, C. J. (2002) Pharmacokinetics of Sodium Nitrite-Induced Methemoglobinemia in the Rat. Drug Metab. Dispos. 30, 676-683.
18. Titov, V. Y., and Petrenko, Y. M. (2005) Proposed Mechanism of Nitrite-Induced Methemoglobinemia. Biochemistry (Moscow) 70, 473-483.
19. Barnard, R. D. (1937) The Reactions of Nitrite with Hemoglobin Derivatives. J. Biol. Chem. 120, 177-191.
20. x Compounds. Chem. Rev. 102, 1067-1089.
21. Nasri, H., Ellison, M. K., Chen, S., Huynh, B. H., and Scheidt, W. R. (1997) Sharing the π-Bonding. An Iron Porphyrin Derivative with Trans, π-Accepting Axial Ligands. Synthesis, EPR and Mössbauer Spectra, and Molecular Structure of Two Forms of the Complex Nitronitrosyl(α,α, α,α-tetrakis(o-pivalamidophenyl) porphinato)ferrate(II). J. Am. Chem. Soc. 119, 6274-6283.
22. 6 Iron Porphyrins with Axial Nitrosyl and Nitro Ligands. J. Am. Chem. Soc. 128, 2093-2104.
23. 3 by the Concerted Nitrite Reductase and Anhydrase Activity of Hemoglobin. Nat. Chem. Biol. 3, 785-794.
24. 5 and the Subunits of Methemoglobin. J. Biol. Chem. 258, 7369-7373.
25. Blumberg, W. E., and Peisach, J. (1971) Low-Spin Compounds of Heme Proteins. Adv. Chem. Ser. 100, 271-291.