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Volumn 20, Issue 9, 2008, Pages 1067-1077

Insulin and the constituent branches of the hepatic vagus interact to modulate hypothalamic and limbic neuropeptide mRNA expression differentially

Author keywords

Corticotrophin releasing factor; Glucocorticoids; Insulin; Neuropeptide Y; Pro opiomelanocortin; Vagus nerve

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; INSULIN; MESSENGER RNA; NEUROPEPTIDE; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; SODIUM CHLORIDE; STREPTOZOCIN;

EID: 49449115890     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2008.01766.x     Document Type: Article
Times cited : (6)

References (51)
  • 2
  • 3
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 2002; 8: 1376-1382.
    • (2002) Nat Med , vol.8 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 4
    • 2042475403 scopus 로고    scopus 로고
    • Interaction between corticosterone and insulin in obesity: Regulation of lard intake and fat stores
    • la Fleur SE, Akana SF, Manalo S, Dallman MF. Interaction between corticosterone and insulin in obesity: Regulation of lard intake and fat stores. Endocrinology 2004; 145: 2174-2185.
    • (2004) Endocrinology , vol.145 , pp. 2174-2185
    • la Fleur, S.E.1    Akana, S.F.2    Manalo, S.3    Dallman, M.F.4
  • 5
    • 33751200642 scopus 로고    scopus 로고
    • Comparison of superior mesenteric versus jugular venous infusions of insulin in streptozotocin-diabetic rats on the choice of caloric intake, body weight, and fat stores
    • Warne JP, Horneman HF, Wick EC, Bhargava A, Pecoraro NC, Ginsberg AB, Akana SF, Dallman MF. Comparison of superior mesenteric versus jugular venous infusions of insulin in streptozotocin-diabetic rats on the choice of caloric intake, body weight, and fat stores. Endocrinology 2006; 147: 5443-5451.
    • (2006) Endocrinology , vol.147 , pp. 5443-5451
    • Warne, J.P.1    Horneman, H.F.2    Wick, E.C.3    Bhargava, A.4    Pecoraro, N.C.5    Ginsberg, A.B.6    Akana, S.F.7    Dallman, M.F.8
  • 6
    • 0025062613 scopus 로고
    • Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats
    • White JD, Olchovsky D, Kershaw M, Berelowitz M. Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats. Endocrinology 1990; 126: 765-772.
    • (1990) Endocrinology , vol.126 , pp. 765-772
    • White, J.D.1    Olchovsky, D.2    Kershaw, M.3    Berelowitz, M.4
  • 7
    • 0026490478 scopus 로고
    • Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats
    • Sahu A, Sninsky CA, Phelps CB, Dube MG, Kalra PS, Kalra SP. Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats. Endocrinology 1992; 131: 2979-2985.
    • (1992) Endocrinology , vol.131 , pp. 2979-2985
    • Sahu, A.1    Sninsky, C.A.2    Phelps, C.B.3    Dube, M.G.4    Kalra, P.S.5    Kalra, S.P.6
  • 8
    • 0033042670 scopus 로고    scopus 로고
    • Stz-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats
    • Kim E-M, Grace MK, Welch C, Billington CJ, Levine AJ. Stz-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats. Am J Physiol 1999; 276: R1320-R1326.
    • (1999) Am J Physiol , vol.276
    • Kim, E.-M.1    Grace, M.K.2    Welch, C.3    Billington, C.J.4    Levine, A.J.5
  • 9
    • 0033969423 scopus 로고    scopus 로고
    • Effects of streptozotocin diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats
    • Havel PJ, Hahn TM, Sindelar DK, G BD, Dallman MF, Weigle DS, Schwartz MW. Effects of streptozotocin diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Diabetes 2000; 49: 244-252.
    • (2000) Diabetes , vol.49 , pp. 244-252
    • Havel, P.J.1    Hahn, T.M.2    Sindelar, D.K.G.B.D.3    Dallman, M.F.4    Weigle, D.S.5    Schwartz, M.W.6
  • 10
    • 0025808275 scopus 로고
    • Chronic streptozotocin diabetes in rats facilitates the acute stress response without altering pituitary or adrenal responsiveness to secretagogues
    • Scribner KA, Walker C-D, Cascio CS, Dallman MF. Chronic streptozotocin diabetes in rats facilitates the acute stress response without altering pituitary or adrenal responsiveness to secretagogues. Endocrinology 1991; 129: 9-108.
    • (1991) Endocrinology , vol.129 , pp. 99-108
    • Scribner, K.A.1    Walker, C.-D.2    Cascio, C.S.3    Dallman, M.F.4
  • 11
    • 14244253564 scopus 로고    scopus 로고
    • Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses
    • Chan O, Inouye K, Akirav E, Park E, Riddell MC, Vranic M, Matthews SG. Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses. Endocrinology 2005; 146: 1382-1390.
    • (2005) Endocrinology , vol.146 , pp. 1382-1390
    • Chan, O.1    Inouye, K.2    Akirav, E.3    Park, E.4    Riddell, M.C.5    Vranic, M.6    Matthews, S.G.7
  • 12
    • 0032527604 scopus 로고    scopus 로고
    • Effect of a high fat diet on food intake and hypothalamic neuropeptide gene expression in streptozotocin diabetes
    • Chavez M, Seeley RJ, Havel PJ, Friedman MI, Matson CA, Woods SC, Schwartz MW. Effect of a high fat diet on food intake and hypothalamic neuropeptide gene expression in streptozotocin diabetes. J Clin Invest 1998; 102: 340-346.
    • (1998) J Clin Invest , vol.102 , pp. 340-346
    • Chavez, M.1    Seeley, R.J.2    Havel, P.J.3    Friedman, M.I.4    Matson, C.A.5    Woods, S.C.6    Schwartz, M.W.7
  • 13
    • 0041820107 scopus 로고    scopus 로고
    • The hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia
    • la Fleur SE, Ji H, Manalo S, Friedman MI, Dallman MF. The hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia. Diabetes 2003; 52: 2321-2330.
    • (2003) Diabetes , vol.52 , pp. 2321-2330
    • la Fleur, S.E.1    Ji, H.2    Manalo, S.3    Friedman, M.I.4    Dallman, M.F.5
  • 14
    • 0031592890 scopus 로고    scopus 로고
    • Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotropin releasing hormone gene expression in diabetes
    • Schwartz MW, Strack AM, Dallman MF. Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotropin releasing hormone gene expression in diabetes. Regul Pept 1997; 72: 105-112.
    • (1997) Regul Pept , vol.72 , pp. 105-112
    • Schwartz, M.W.1    Strack, A.M.2    Dallman, M.F.3
  • 15
    • 0027168223 scopus 로고
    • Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y
    • Heinrichs SC, Menzaghi F, Pich EM, Hauger RL, Koob GF. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain Res 1993; 611: 18-24.
    • (1993) Brain Res , vol.611 , pp. 18-24
    • Heinrichs, S.C.1    Menzaghi, F.2    Pich, E.M.3    Hauger, R.L.4    Koob, G.F.5
  • 16
    • 0026468098 scopus 로고
    • Endogenous corticotropin-releasing factor modulates feeding induced by neuropeptide Y or a tail-pinch stressor
    • Heinrichs SC, Cole BJ, Pich EM, Menzaghi F, Koob GF, Hauger RL. Endogenous corticotropin-releasing factor modulates feeding induced by neuropeptide Y or a tail-pinch stressor. Peptides 1992; 13: 879-884.
    • (1992) Peptides , vol.13 , pp. 879-884
    • Heinrichs, S.C.1    Cole, B.J.2    Pich, E.M.3    Menzaghi, F.4    Koob, G.F.5    Hauger, R.L.6
  • 17
    • 0041319087 scopus 로고    scopus 로고
    • Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses
    • Lu X-Y, Barsh GS, Akil H, Watson SJ Jr. Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci 2003; 23: 7863-7872.
    • (2003) J Neurosci , vol.23 , pp. 7863-7872
    • Lu, X.-Y.1    Barsh, G.S.2    Akil, H.3    Watson Jr., S.J.4
  • 19
    • 0142188643 scopus 로고    scopus 로고
    • The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/ orphanin FQ
    • Ciccocioppo R, Fedeli A, Economidou D, Policani F, Weiss F, Massi M. The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ. J Neurosci 2003; 23: 9445-9551.
    • (2003) J Neurosci , vol.23 , pp. 9445-9551
    • Ciccocioppo, R.1    Fedeli, A.2    Economidou, D.3    Policani, F.4    Weiss, F.5    Massi, M.6
  • 20
    • 20644434158 scopus 로고    scopus 로고
    • Hepatic vagotomy alters limbic and hypothalamic neuropeptide responses to streptozotocin-diabetes and voluntary lard ingestion
    • la Fleur SE, Manalo S, Roy M, Houshyar H, Dallman MF. Hepatic vagotomy alters limbic and hypothalamic neuropeptide responses to streptozotocin-diabetes and voluntary lard ingestion. Eur J Neurosci 2005; 21: 2733-2742.
    • (2005) Eur J Neurosci , vol.21 , pp. 2733-2742
    • la Fleur, S.E.1    Manalo, S.2    Roy, M.3    Houshyar, H.4    Dallman, M.F.5
  • 21
    • 0034695176 scopus 로고    scopus 로고
    • Functional and chemical anatomy of the afferent vagal system
    • Berthoud H-R, Neuhuber WL. Functional and chemical anatomy of the afferent vagal system. Auton Neurosci 2000; 85: 1-17.
    • (2000) Auton Neurosci , vol.85 , pp. 1-17
    • Berthoud, H.-R.1    Neuhuber, W.L.2
  • 23
    • 34548300032 scopus 로고    scopus 로고
    • Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats
    • Warne JP, Foster MT, Horneman HF, Pecoraro NC, Ginsberg AB, Akana SF, Dallman MF. Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats. J Physiol 2007; 583: 455-467.
    • (2007) J Physiol , vol.583 , pp. 455-467
    • Warne, J.P.1    Foster, M.T.2    Horneman, H.F.3    Pecoraro, N.C.4    Ginsberg, A.B.5    Akana, S.F.6    Dallman, M.F.7
  • 26
    • 0022151434 scopus 로고
    • Corticosterone: Narrow range required for normal body and thymus weight and ACTH
    • Akana SF, Cascio CS, Shinsako J, Dallman MF. Corticosterone: Narrow range required for normal body and thymus weight and ACTH. Am J Physiol 1985; 249: R527-R532.
    • (1985) Am J Physiol , vol.249
    • Akana, S.F.1    Cascio, C.S.2    Shinsako, J.3    Dallman, M.F.4
  • 27
    • 0242551878 scopus 로고    scopus 로고
    • Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular nucleus of the hypothalamus
    • Ginsberg AB, Campeau S, Day HE, Spencer RL. Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular nucleus of the hypothalamus. J Neuroendocrinol 2003; 15: 1075-1083.
    • (2003) J Neuroendocrinol , vol.15 , pp. 1075-1083
    • Ginsberg, A.B.1    Campeau, S.2    Day, H.E.3    Spencer, R.L.4
  • 29
    • 0022555988 scopus 로고
    • Localization of 125 I-insulin binding sites in the rat hypothalamus by quantitative autoradiography
    • Corp ES, Woods SC, Porte D Jr, Dorsa DM, Figlewicz DP, Baskin DG. Localization of 125 I-insulin binding sites in the rat hypothalamus by quantitative autoradiography. Neurosci Lett 1986; 70: 17-22.
    • (1986) Neurosci Lett , vol.70 , pp. 17-22
    • Corp, E.S.1    Woods, S.C.2    Porte Jr., D.3    Dorsa, D.M.4    Figlewicz, D.P.5    Baskin, D.G.6
  • 30
    • 0027373646 scopus 로고
    • Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: Colocalization with phosphotyrosine
    • Baskin DG, Sipols AJ, Schwartz MW, White MF. Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine. Regul Pept 1993; 48: 257-266.
    • (1993) Regul Pept , vol.48 , pp. 257-266
    • Baskin, D.G.1    Sipols, A.J.2    Schwartz, M.W.3    White, M.F.4
  • 31
    • 0028924906 scopus 로고
    • Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression
    • Sipols AJ, Baskin DG, Schwartz MW. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 1995; 44: 147-151.
    • (1995) Diabetes , vol.44 , pp. 147-151
    • Sipols, A.J.1    Baskin, D.G.2    Schwartz, M.W.3
  • 32
    • 0029078980 scopus 로고
    • Region-specific regulation of neuropeptide mrnas in rat limbic forebrain neurones by aldosterone and corticosterone
    • Watts AG, Sanchez-Watts G. Region-specific regulation of neuropeptide mrnas in rat limbic forebrain neurones by aldosterone and corticosterone. J Physiol 1995; 484: 721-736.
    • (1995) J Physiol , vol.484 , pp. 721-736
    • Watts, A.G.1    Sanchez-Watts, G.2
  • 33
    • 33750319701 scopus 로고    scopus 로고
    • Corticotropin-releasing factor and its receptors in the brain of rats with insulin and corticosterone deficits
    • Huang Q, Timofeeva E, Richard D. Corticotropin-releasing factor and its receptors in the brain of rats with insulin and corticosterone deficits. J Mol Endocrinol 2006; 37: 213-226.
    • (2006) J Mol Endocrinol , vol.37 , pp. 213-226
    • Huang, Q.1    Timofeeva, E.2    Richard, D.3
  • 34
    • 0034750619 scopus 로고    scopus 로고
    • Molecular reguation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: Effects of insulin treatment
    • Chan O, Chan S, Inouye K, Vranic M, Matthews SG. Molecular reguation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: Effects of insulin treatment. Endocrinology 2001; 142: 4872-4879.
    • (2001) Endocrinology , vol.142 , pp. 4872-4879
    • Chan, O.1    Chan, S.2    Inouye, K.3    Vranic, M.4    Matthews, S.G.5
  • 35
    • 3843118760 scopus 로고    scopus 로고
    • Chronic stress promotes palatable feeding, which reduces signs of stress: Feedforward and feedback effects of chronic stress
    • Pecoraro N, Reyes F, Gomez F, Bhargava A, Dallman MF. Chronic stress promotes palatable feeding, which reduces signs of stress: Feedforward and feedback effects of chronic stress. Endocrinology 2004; 145: 3754-3762.
    • (2004) Endocrinology , vol.145 , pp. 3754-3762
    • Pecoraro, N.1    Reyes, F.2    Gomez, F.3    Bhargava, A.4    Dallman, M.F.5
  • 36
    • 0034991497 scopus 로고    scopus 로고
    • Sucrose ingestion normalizes central expression of corticotropin-releasing-factor messenger ribonucleic acid and energy balance in adrenalectomized rats: A glucocorticoid-metabolic-brain axis?
    • Laugero KD, Bell ME, Bhatnagar S, Soriano L, Dallman MF. Sucrose ingestion normalizes central expression of corticotropin-releasing-factor messenger ribonucleic acid and energy balance in adrenalectomized rats: A glucocorticoid-metabolic-brain axis? Endocrinology 2001; 142: 2796-2804.
    • (2001) Endocrinology , vol.142 , pp. 2796-2804
    • Laugero, K.D.1    Bell, M.E.2    Bhatnagar, S.3    Soriano, L.4    Dallman, M.F.5
  • 37
    • 0036892148 scopus 로고    scopus 로고
    • Corticosterone infused intracerebroventricularly inhibits energy storage and stimulates the hypothalamo-pituitary axis in adrenalectomized rats drinking sucrose
    • Laugero KD, Gomez F, Manalo S, Dallman MF. Corticosterone infused intracerebroventricularly inhibits energy storage and stimulates the hypothalamo-pituitary axis in adrenalectomized rats drinking sucrose. Endocrinology 2002; 143: 4552-4562.
    • (2002) Endocrinology , vol.143 , pp. 4552-4562
    • Laugero, K.D.1    Gomez, F.2    Manalo, S.3    Dallman, M.F.4
  • 38
    • 0035693435 scopus 로고    scopus 로고
    • Topography of projections from amygdala to bed nuclei of the stria terminalis
    • Dong HW, Petrovich GD, Swanson LW. Topography of projections from amygdala to bed nuclei of the stria terminalis. Brain Res Brain Res Rev 2001; 38: 192-246.
    • (2001) Brain Res Brain Res Rev , vol.38 , pp. 192-246
    • Dong, H.W.1    Petrovich, G.D.2    Swanson, L.W.3
  • 40
    • 0019458387 scopus 로고
    • Insulin and insulin receptors in rodent brain
    • Havrankova J, Brownstein M, Roth J. Insulin and insulin receptors in rodent brain. Diabetologia 1981; 20 (Suppl.): 268-273.
    • (1981) Diabetologia , vol.20 , Issue.SUPPL. , pp. 268-273
    • Havrankova, J.1    Brownstein, M.2    Roth, J.3
  • 41
    • 34347358488 scopus 로고    scopus 로고
    • The sensory circumventricular organs: Brain targets for circulating signals controlling ingestive behavior
    • Fry M, Ferguson AV. The sensory circumventricular organs: Brain targets for circulating signals controlling ingestive behavior. Physiol Behav 2007; 91: 413-423.
    • (2007) Physiol Behav , vol.91 , pp. 413-423
    • Fry, M.1    Ferguson, A.V.2
  • 45
    • 34248204584 scopus 로고    scopus 로고
    • Characterization of glucosensing neuron subpopulations in the arcuate nucleus: Integration in neuropeptide Y and pro-opiomelanocortin networks?
    • Fioramonti X, Contie S, Song Z, Routh VH, Lorsignol A, Penicaud L. Characterization of glucosensing neuron subpopulations in the arcuate nucleus: Integration in neuropeptide Y and pro-opiomelanocortin networks? Diabetes 2007; 56: 1219-1227.
    • (2007) Diabetes , vol.56 , pp. 1219-1227
    • Fioramonti, X.1    Contie, S.2    Song, Z.3    Routh, V.H.4    Lorsignol, A.5    Penicaud, L.6
  • 46
    • 0033515710 scopus 로고    scopus 로고
    • Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y
    • Muroya S, Yada T, Shioda S, Takigawa M. Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y. Neurosci Lett 1999; 264: 113-116.
    • (1999) Neurosci Lett , vol.264 , pp. 113-116
    • Muroya, S.1    Yada, T.2    Shioda, S.3    Takigawa, M.4
  • 47
    • 0018196413 scopus 로고
    • Vagal glucoreceptors in the small intestine of the cat
    • Mei N. Vagal glucoreceptors in the small intestine of the cat. J Physiol 1978; 282: 485-506.
    • (1978) J Physiol , vol.282 , pp. 485-506
    • Mei, N.1
  • 48
    • 0035829039 scopus 로고    scopus 로고
    • Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity
    • Randich A, Spraggins DS, Cox JE, Meller ST, Kelm GR. Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity. Neuroreport 2001; 12: 3101-3105.
    • (2001) Neuroreport , vol.12 , pp. 3101-3105
    • Randich, A.1    Spraggins, D.S.2    Cox, J.E.3    Meller, S.T.4    Kelm, G.R.5
  • 49
    • 0035047069 scopus 로고    scopus 로고
    • Effect of lysine on afferent activity of the hepatic branch of the vagus nerve in normal and L-lysine-deficient rats
    • Torii K, Niijima A. Effect of lysine on afferent activity of the hepatic branch of the vagus nerve in normal and L-lysine-deficient rats. Physiol Behav 2001; 72: 685-690.
    • (2001) Physiol Behav , vol.72 , pp. 685-690
    • Torii, K.1    Niijima, A.2
  • 50
    • 0037146943 scopus 로고    scopus 로고
    • Effects of adrenalectomy on AgRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats
    • Savontaus E, Conwell IM, Wardlaw SL. Effects of adrenalectomy on AgRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats. Brain Res 2002; 958: 130-138.
    • (2002) Brain Res , vol.958 , pp. 130-138
    • Savontaus, E.1    Conwell, I.M.2    Wardlaw, S.L.3
  • 51
    • 34347232348 scopus 로고    scopus 로고
    • Vagus nerve stimulation therapy for treatment of drug-resistant epilepsy and depression
    • Shafique S, Dalsing MC. Vagus nerve stimulation therapy for treatment of drug-resistant epilepsy and depression. Perspect Vasc Surg Endovasc Ther 2006; 18: 323-327.
    • (2006) Perspect Vasc Surg Endovasc Ther , vol.18 , pp. 323-327
    • Shafique, S.1    Dalsing, M.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.