Novel analogues of istaroxime, a potent inhibitor of Na+,K +-ATPase: Synthesis and structure-activity relationship

Journal of Medicinal Chemistry

Volumn 51, Issue 15, 2008, Pages 4601-4608

  Gobbini, Mauro ^a   Armaroli, Silvia ^a,b   Banfi, Leonardo ^a   Benicchio, Alessandra ^a   Carzana, Giulio ^a   Fedrizzi, Giorgio ^a   Ferrari, Patrizia ^a   Giacalone, Giuseppe ^a   Giubileo, Michele ^a   Marazzi, Giuseppe ^a   Micheletti, Rosella ^a   Moro, Barbara ^a   Pozzi, Marco ^a   Scotti, Piero Enrico ^a   Torri, Marco ^a   Cerri, Alberto ^a  

^a Prassis Sigma Tau Research Institute   (Italy)

^b Sigma Tau Research Switzerland   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 AMINO 1 PROPOXYIMINO)ANDROSTANE 6,17 DIONE; 3 (2 AMINO 1 PROPOXYIMINO)ANDROSTANE 6,17 DIONE FURAMATE; 3 (2 AMINO 2 METHYL 1 PROPOXYIMINO)ANDROSTANE 6,17 DIONE; 3 (2 AMINO EXTHOXYIMINO)ANDROSTANE 6,17 DIONE FUMARATE; 3 (2 AMINOETHOXYIMINO)ANDROSTANE 6,17 DIONE FUMARATE; 3 (2 GUANIDINOETHOXYIMINO)ANDROSTANE 6,17 DIONE NITRATE; 3 (2 METHYLAMINOETHOXYIMINO)ANDROSTANE 6,17 DIONE; 3 (3 AMINO 2 METHYL 2 PROPOXYIMINO)ANDROSTANE 6,17 DIONE FUMURATE; 3 (3 GUANIDINOETHOXYIMINO)ANDROSTANE 6,17 DIONE; 3 (3 PYRROLIDINYL)OXYIMINOANDROSTANE 6,17 DIONE; 3 (3 PYRROLIDINYLOXYIMINO)ANDROSTANE 6,17 DIONE; 3 (4 AMINOETHOXYIMINO)ANDROSTANE 6,17 DIONE; 3 93 AZETIDINYLOXYIMINO0ANDROSTANE 6,17 DIONE FUMURATE; 3 [2 PYRROLIDINYLMETHOXYIMINO]ANDROSTANE 6,17 DIONE HYDROCHLORIDE; 3 [3 (1 METHYL)PYRROLIDILOXYIMINO]ANDROSTANE 6,17 DIONE; 3 [3 (1 METHYL)PYRROLIDILOXYIMINO]ANDROSTANE 6,17 DIONE HYDROCHLORIDE; 3 [3 METHYLAMINOETHOXYIMINO] 6ALPHA HYDROXYANDROSTRANE 17 ONE HYDROCHLORIDE; 3 [3 PIPERIDINYLOXYIMINO]ANDROSTANE 6,17 DIONE HYDROCHLORIDE; 3 [3 PYRROLIDINYL]OXYIMINO 6ALPHA HYDROXYANDROSTRANE 17 ONE HYDROCHLORIDE; 3 [3 PYRROLIDINYL]OXYIMINO 6BETA HYDROXYANDROSTRANE 17 ONE HYDROCHLORIDE; 3 [4 PIPERIDINYLOXYIMINO]ANDROSTANE 6,17 DIONE HYDROCHLORIDE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) INHIBITOR; DIGOXIN; ISTAROXIME; PST 2744; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG POTENCY; DRUG SAFETY; DRUG SYNTHESIS; GUINEA PIG; INOTROPISM; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; ETIOCHOLANOLONE; GUINEA PIGS; HYDROXYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SODIUM-POTASSIUM-EXCHANGING ATPASE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 49449108728     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800257s     Document Type: Article

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