Isolated porcine bronchi provide a reliable model for development of bronchodilator anti-muscarinic agents for human use

British Journal of Pharmacology

Volumn 154, Issue 8, 2008, Pages 1611-1618

  D'Agostino, G ^a   Condino, A M ^a   Gioglio, L ^a   Zonta, F ^a   Tonini, M ^a   Barbieri, A ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Muscarinic antagonists; Muscarinic receptor subtypes; NMS binding; Pig airways; Smooth muscle contraction

Indexed keywords

11 (1 PIPERIDINYLACETYL) 5,11 DIHYDRO 6H PYRIDOBENZODIAZEPIN 6 ONE; 11 [[4 [4 (DIETHYLAMINO)BUTYL] 1 PIPERIDINYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; 11 [[4 [4 (DIETHYLAMINO)BUTYL] 1 PIPERIDYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; 4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; 8 METHYL 8 AZABICYCLO 3 ENDOOCT 3 YL 14 DIHYDRO 2 OXO 3(2H) QUINAZOLINE CARBOXYLIC ACID ESTER; AF DX 250; BENZODIAZEPINE DERIVATIVE; BETHANECHOL; BRONCHODILATING AGENT; CARBACHOL; CARBOXYLIC ACID DERIVATIVE; DAU 5884; HEXAHYDROSILADIFENIDOL; MAMBA TOXIN 3; METHACHOLINE; METHOCTRAMINE; METHYLSCOPOLAMINE; MUSCARINE; MUSCARINIC M1 RECEPTOR ANTAGONIST; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; MUSCARONE; OXOTREMORINE; PIPERIDINE DERIVATIVE; PIRENZEPINE; QUINAZOLINE DERIVATIVE; TRIPITRAMINE;

AIRWAY RESISTANCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BRONCHODILATATION; BRONCHUS; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG RECEPTOR BINDING; ELECTRON MICROSCOPY; EXPERIMENTAL MODEL; HUMAN; ISOLATED ORGAN; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; SPECIES DIFFERENTIATION; SWINE;

ANIMALS; BINDING, COMPETITIVE; BRONCHI; BRONCHODILATOR AGENTS; DISEASE MODELS, ANIMAL; DRUG DESIGN; HUMANS; MICROSCOPY, ELECTRON; MUSCARINIC ANTAGONISTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; SPECIES SPECIFICITY; SWINE;

EID: 49449102742     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.208     Document Type: Article

References (45)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edn. Br J Pharmacol 153 (Suppl. 2): S1-S209.
2. Arunlakshana O, Schild HO (1959). Some quantitative uses of drug antagonists. Br J Pharmacol 14: 48-58.
3. Barnes PJ (1986). Neural control of human airways in health and disease. Am Rev Respir Dis 134: 1289-1324.
4. Barnes PJ (1987). Cholinergic control of airway smooth muscle. Am Rev Respir Dis 136: S42-S45.
5. Barnes PJ (2004). Distribution of receptor targets in the lung. Proc Am Thorac Soc 1: 345-351.
6. Bloom JW, Halonen M, Yamamura HI (1988). Characterisation of muscarinic receptor subtypes in human peripheral lung. J Pharmacol Exp Ther 244: 625-632.
7. Buckley NJ, Bonner TI, Buckley CM, Brann MR (1989). Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol 35: 469-476.
8. Catalli A, Zhang D, Janssen LJ (2002). Receptors and signaling pathway underlying relaxations to isoprostanes in canine and porcine airway smooth muscle. Am Physiol Lung Cell Mol Physiol 283: L1151-L1159.
9. Chelala JL, Kilani A, Miller MJ, Martin RJ, Ernsberger P (1998). Muscarinic receptor binding sites of the M4 subtype in porcine lung parenchyma. Pharmacol Toxicol 83: 200-207.
10. 50) of an enzymatic reaction. Biochem Pharmacol 22: 3099-3108.
11. Daniel EE, Kannan M, Davis C, Posey-Daniel V (1986). Ultrastructural studies on the neuromuscular control of human tracheal and bronchial muscle. Respir Physiol 63: 109-128.
12. 4 receptor subtype. Br J Pharmacol 129: 493-500.
13. D'Agostino G, Chiari MC, Grana E, Subissi A, Kilbinger H (1990). Muscarinic inhibition of acetylcholine release from a novel in vitro preparation of the guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol 342: 141-145.
14. Dörje F, Levey AI, Brann MR (1991a). Immunological detection of muscarinic receptors subtypes proteins (m1-m5) in rabbit peripheral lung. Mol Pharmacol 40: 459-462.
15. Dörje F, Wess J, Lambrecht G, Tacke R, Mutschler E, Brann MR (1991b). Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther 256: 727-733.
16. Eglen RM, Hedge SS, Watson N (1996). Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 48: 531-565.
17. Eglen RM, Michel AD, Montgomery WW, Kunysz EA, Machado CA, Whiting RL (1990). The interaction of para-fluorohexahydrosiladifenidol at muscarinic receptors in vitro. Br J Pharmacol 99: 637-642.
18. 5 receptor: a silent or emerging subtype? Br J Pharmacol 130: 13-21.
19. El-Bermani AIW, Grant M (1975). Acetylcholinoesterase-positive nerves of Rhesus monkey bronchial tree. Thorax 30: 162-170.
20. Gies JP, Bertrand C, Vanderheyden P, Waeldele F, Dumont P, Pauli G et al. (1989). Characterisation of muscarinic receptors in human, guinea pig and rat lung. J Pharmacol Exp Ther 250: 309-315.
21. Gosens R, Zaagma J, Meurs H, Halayko AJ (2006). Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res 7: 73.
22. Guo ZD, Kameyama K, Rinken A, Haga T (1995). Ligand binding properties of muscarinic acetylcholine receptor subtypes (m1-m5) expressed in baculovirus-infected insect cells. J Pharmacol Exp Ther 274: 378-384.
23. Haddad EB, Mak JC, Hislop A, Haworth SG, Barnes PJ (1994). Characterisation of muscarinic receptor subtypes in pig airways: radioligand binding and northern blotting studies. Am J Physiol 266: L642-L648.
24. Hall RA, Premont RT, Lefkowitz RJ (1999). Heptahelical receptor signaling: beyond the G protein paradigm. J Cell Biol 145: 927-932.
25. Hawarth SG, Hislop AA (1981). Adaptation of the pulmonary circulation to extra-uterine life in the pig and its relevance to the human infant. Cardiovasc Res 15: 108-119.
26. Hedge SS, Choppin A, Bonhaus D, Briaud S, Loeb M, Moy TM et al. (1997). Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol 120: 1409-1418.
27. Hislop AA, Mak JC, Reader JA, Barnes PJ, Haworth SG (1998). Muscarinic receptor subtypes in the porcine lung during postnatal development. Eur J Pharmacol 359: 211-221.
28. Klapproth H, Reinheimer T, Metzen J, Münch M, Bittinger F, Kirkpatrick CJ et al. (1997). Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man. Naunyn Schmiedeberg's Arch Pharmacol 355: 515-523.
29. 4 binding sites in in rabbit lung, chicken heart, and NG108 15 cells. Mol Pharmacol 38: 805-815.
30. Maggio R, Barbieri P, Bolognesi ML, Minarini A, Tedeschi D, Melchiorre C (1994). Binding profile of the selective muscarinic receptor antagonist tripitramine. Eur J Pharmacol 268: 459-462.
31. Mak JC, Barnes PJ (1989). Muscarinic receptor subtypes in human and guinea pig lung. Eur J Pharmacol 164: 223-230.
32. Mak JC, Barnes PJ (1990). Autoradiographic visualization of muscarinic receptor subtypes in human and guinea pig lung. Am Rev Respir Dis 141: 1559-1568.
33. Mak JC, Baraniuk JN, Barnes PJ (1992). Localization of muscarinic receptor subtype mRNAs in human lung. Am J Respir Cell Mol Biol 7: 344-348.
34. 4-receptor subtypes in rabbit lung. Life Sci 53: 1501-1508.
35. Patel HJ, Barnes PJ, Takahashi T, Tadjkarimi S, Yacoub MH, Belvisi MG (1995). Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea. Am J Respir Crit Care Med 152: 872-878.
36. Racké K, Matthiesen S (2004). The airway cholinergic system: physiology and pharmacology. Pulm Pharmacol Ther 17: 81-198.
37. Roffel AF, Elzinga CR, Zaagsma J (1990). Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle. Pulm Pharmacol 3: 47-51.
38. 2-like receptors. Eur J Pharmacol 250: 267-279.
39. Stuart-Smith K, Vanhoutte P (1988). Airways epithelium modulates the responsiveness of porcine bronchial smooth musle. J Appl Physiol 65: 721-727.
40. ten Berge RE, Zaagsma J, Roffel AF (1996). Muscarinic inhibitory autoreceptors in different generations of human airways. Am J Respir Crit Care Med 154: 43-49.
41. van Koppen CJ, Blankesteijn WM, Klassen AB, Rodriguez de Miranda JF, Beld AJ, van Ginneken CA (1987). Autoradiographic visualization of muscarinic receptors in pulmonary nerves and ganglia. Neurosci Lett 83: 237-240.
42. van Koppen CJ, Blankesteijn WM, Klassen AB, Rodriguez de Miranda JF, Beld AJ, van Ginneken CA (1988). Autoradiographic visualization of muscarinic receptors in human bronchi. J Pharmacol Exp Ther 244: 760-764.
43. van Koppen CJ, Rodriguez de Miranda JF, Beld AJ, Hermanussen MW, Lammers JW, van Ginneken CA (1985). Characterisation of the muscarinic receptor in human tracheal smooth muscle. Naunyn Schmiedebergs Arch Pharmacol 331: 247-252.
44. Watson N, Magnussen H, Rabe KF (1995). Pharmacological characterisation of the muscarinic receptor subtype mediating contraction of human peripheral airways. J Pharmacol Exp Ther 274: 1293-1297.
45. Yasuda RP, Ciesla W, Wall SJ, Li M, Satkuss SA, Weisstein JS et al. (1993). Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: distribution of m4 and m5 receptors in rat brain. Mol Pharmacol 43: 149-157.