Exact trait-model-free tests for linkage detection in pedigrees

Annals of Human Genetics

Volumn 72, Issue 5, 2008, Pages 676-682

  Basu, Saonli ^a   Di, Y ^b   Thompson, E A ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Exact tests for linkage; Identity by descent; Trait model free

Indexed keywords

ALLELE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXACT TRAIT MODEL FREE TEST; FEMALE; GENE FREQUENCY; GENEALOGY; GENETIC LINKAGE; GENOMICS; GENOTYPE; HUMAN; MALE; MARKER GENE; PEDIGREE; PERMUTATION TEST; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SCORING SYSTEM; STATISTICAL ANALYSIS;

ALLELES; BIOMETRY; FEMALE; GENETIC MARKERS; HUMANS; LINKAGE (GENETICS); MALE; MODELS, GENETIC; PEDIGREE; PHENOTYPE;

EID: 49449099049     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2008.00451.x     Document Type: Article

References (18)

1. Basu, S. (2005) Allele-sharing methods for linkage detection in large pedigrees. Ph.D. thesis, Department of Statistics, University of Washington, Seattle, WA.
2. Churchill, G. A. & Doerge, R. (1994) Empirical threshold values for quantitative trait mapping. Genetics 238, 963-971.
3. Davis, S. and others. (1996) Nonparametric simulation-based statistics for detecting linkage in general pedigrees. Am J Hum Genet 58, 867-880.
4. Day, N. E. & Simons, M. J. (1976) Disease-susceptibility genes - their identification by multiple case family studies. Tissue Antigens 8, 109-119.
5. Feingold, E. (2001) Methods for linkage analysis of quantitative trait loci in humans. Theor Popul Biol 60, 167-180.
6. Fisher, R. A. (1935) The Design of Experiments. Third Edition. London: Oliver and Boyd Ltd.
7. Fishman, P. M. & others. (1978) A robust method for the detection of linkage. Am J Hum Genet 30, 308-321.
8. Heath, S. (1997) Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Human Genet 61, 748-760.
9. Kong, A. & Cox, N. (1997) Allele-sharing models: Lod scores and accurate linkage tests. Am J Hum Genet 61, 1179-1188.
10. Kruglyak, L. & others. (1996) Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58, 1347-1363.
11. Lander, E. S. & Green, P. (1987) Construction of multilocus genetic maps in humans. Proceedings of National Academy of Sciences USA 84, 2363-2367.
12. Shih, M. C. & Whittemore, A. S. (2001) Allele-sharing among affected relatives: Non-parametric methods for identifying genes. statistical methods in medical research 10, 27-55.
13. Suarez, B. K. & Hodge, S. E. (1979) A simple method to detect linkage for rare recessive diseases: An application to juvenile diabetes. Clinical Genetics 15, 126-136.
14. Thompson, E. A. (2000) Statistical Inferences from Genetic Data on Pedigrees. Vol. 6. NSF-CBMS Regional Conference Series in Probability and Statistics, I.M.S, Beachwood, OH.
15. Thompson, E. A. & Basu, S. (2003) Genome sharing in large pedigrees: multiple imputation of ibd for linkage detection. Human Heredity 56, 119-125.
16. Thompson, E. A. & Geyer, C. J. (2007) Fuzzy p-values in latent variable problems. Biometrika 94, 49-60.
17. Weeks, D. & Lange, K. (1988) The affected-pedigree-member method of linkage analysis. Am J Hum Genet 42, 315-326.
18. Whittemore, A. S. & Halpern, J. (1994) A class of tests for linkage using affected pedigree members. Biometrics 50, 118-127.