Genome sharing in large pedigrees: Multiple imputation of ibd for linkage detection

Human Heredity

Volumn 56, Issue 1-3, 2003, Pages 119-125

  Thompson, Elizabeth ^a   Basu, Saonli ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Identity by descent; Inheritance vector; MCMC; Multiple imputation

Indexed keywords

CONFERENCE PAPER; GENE LOCUS; GENETIC IDENTIFICATION; GENETIC LINKAGE; GENETIC MARKER; GENETIC TRAIT; GENOME; HUMAN; MONTE CARLO METHOD; PEDIGREE; PROBABILITY; SAMPLING; SIMULATION;

CHROMOSOME MAPPING; DATA INTERPRETATION, STATISTICAL; GENETIC MARKERS; HUMANS; LINKAGE (GENETICS); PEDIGREE;

EID: 0345257820     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000073739     Document Type: Conference Paper

References (17)

1. Thompson EA: Statistical Inferences from Genetic Data on Pedigrees, vol. 6 of NSF-CBMS Regional Conference Series in Probability and Statistics. Institute of Mathematical Statistics, Beachwood, OH, 2000.
2. Sobel E, Lange K: Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 1996;58:1323-1337.
3. Donnelly KP: The probability that related individuals share some section of genome identical by descent. Theor Popul Biol 1983;23:34-63.
4. Lander ES, Green P: Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 1987;84:2363-2367.
5. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES: Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996;58:1347-1363.
6. Baum LE, Petrie T, Soules G, Weiss N: A maximization technique occurring in the statistical analysis of probabilistic functions on Markov chains. Ann Math Stat 1970;41:164-171.
7. Gudbjartsson D, Jonasson K, Frigge M, Kong A: Allegro, a new computer program for multi-point linkage analysis. Nat Genet 2000;25:12-13.
8. Penrose LS: The detection of autosomal linkage in data which consist of pairs of brothers and sisters of unspecified parentage. Ann Eugenics 1935;6:133-138.
9. Suarez BK, Rice J, Reich T: The generalized sib pair IBD distribution: Its use in the detection of linkage. Ann Hum Genet 1978;42:87-94.
10. Whittemore A, Halpern J: A class of tests for linkage using affected pedigree members. Biometrics 1994;50:118-127.
11. McPeek MS: Optimal allele-sharing statistics for genetic mapping using affected relatives. Genet Epidemiol 1999;16:225-249.
12. Churchill GA, Doerge RW: Empirical threshold values for quantitative trait mapping. Genetics 1994;138:963-971.
13. Davis S, Schroeder M, Goldin LR, Weeks DE: Nonparametric simulation based statistics for detecting linkage in general pedigrees. Am J Hum Genet 1996;53:867-880.
14. Basu S, Wijsman EM, Thompson EA: Allele-sharing methods on large pedigrees. Genet Epidemiol 2002;23:267.
15. Anderson TW, Darling DA: A test of goodness of fit. J Am Stat Ass 1954;49:765-769.
16. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD: Familial Alzheimer's disease locus on chromosome 1. Science 1995;269:970-973.
17. Thompson EA: Linkage detection for complex traits. In Invited Proceedings of the 54nd Session of the International Statistical Institute. 2003, in press.