Total synthesis of thiostrepton, part 1: Construction of the dehydropiperidine/thiazoline-containing macrocycle

Angewandte Chemie - International Edition

Volumn 43, Issue 38, 2004, Pages 5087-5092

  Nicolaou, K C ^a   Safina, Brian S ^a   Zak, Mark ^a   Estrada, Anthony A ^a   Lee, Sang Hyup ^a  

^a NONE

Author keywords

Antibiotics; Azadienes; Cycloaddition; Natural products; Total synthesis

Indexed keywords

DIMERIZATION; DIMERS; RNA; SYNTHESIS (CHEMICAL);

SELECTIVE ELABORATION; THIOSTREPTON;

ANTIBIOTICS;

ALKADIENE; AZADIENE; PIPERIDINE DERIVATIVE; RNA; TETRAHYDROPYRIDINE; THIOSTREPTON; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DIELS ALDER REACTION; DIMERIZATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; PLASMODIUM FALCIPARUM; RNA BINDING; STREPTOMYCES; STREPTOMYCES AZUREUS;

MACROCYCLIC COMPOUNDS; MOLECULAR CONFORMATION; PIPERIDINES; THIAZOLES; THIOSTREPTON;

EID: 4944238016     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200461340     Document Type: Article

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