Cognitive performance in recreational ecstasy polydrug users: A two-year follow-up study

Journal of Psychopharmacology

Volumn 22, Issue 5, 2008, Pages 498-510

  De Sola Llopis, S ^a   Miguelez Pan, M ^a   Pena Casanova J ^a   Poudevida, S ^a   Farre M ^b   Pacifici, R ^c   Bohm P ^a   Abanades, S ^b   Verdejo Garcia A ^a   Langohr, K ^d   Zuccaro, P ^c   De La Torre, R ^a,e  

^a HOSPITAL DEL MAR   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^e UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Cannabis; Cognitive impairment; Ecstasy; MDMA

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; CANNABIS;

ADULT; ARTICLE; ATTENTION; COGNITIVE DEFECT; CONTROLLED STUDY; EPISODIC MEMORY; FEMALE; FOLLOW UP; HUMAN; INFORMATION PROCESSING; LEARNING; LEARNING DISORDER; MAJOR CLINICAL STUDY; MALE; MEMORY; MEMORY DISORDER; MOTOR PERFORMANCE; MULTIPLE DRUG ABUSE; NEUROTOXICITY; PRIORITY JOURNAL; SEMANTICS; SEROTONINERGIC SYSTEM; TASK PERFORMANCE; TOBACCO; VERBAL COMMUNICATION; WORKING MEMORY;

ADULT; COGNITION DISORDERS; DRUG SYNERGISM; FEMALE; FOLLOW-UP STUDIES; HALLUCINOGENS; HUMANS; MALE; MARIJUANA ABUSE; MEMORY DISORDERS; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; STREET DRUGS; SUBSTANCE-RELATED DISORDERS; YOUNG ADULT;

EID: 49349105923     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881107081545     Document Type: Article

References (71)

1. Benton A.L., Hamsher K., Sivan A.B. (1983) Multilingual aphasia examination. third edition, Iowa City, IA: AJA Associates
2. Bhattachary S., Powell J.H. (2001) Recreational use of 3-4-methyledioxymethanphetamine (MDMA) or "ecstasy": evidence for cognitive impairment. Psychol Med 31: 647-658
3. Bolla K.I., McCann U.D., Ricaurte G.A. (1998) Memory impairment in abstinent MDMA ("MDMA") users. Neurology 51: 1532-1537
4. Bor D., Duncan J., Lee A.C., Parr A., Owen A.M. (2006) Frontal lobe involvement in spatial span: converging studies of normal and impaired function. Neuropsychologia 44: 229-237
5. Buchert R., Thomasius R., Nebeling B., Petersen K., Obrocki J., Jenicke L., Wilke F., Wartberg L., Zapletalova P., Clausen M. (2003) Long-term effects of "ecstasy" use on serotonin transporters of the brain investigated by PET. J Nucl Med 44: 375-384
6. Cami J., Farre M., Mas M., Roset P.N., Poudevida S., Mas A., San L., de la Torre R. (2000) Human pharmacology of 3-4methylenedioxymethamphetamine ("ecstasy"). psychomotor performance and subjective effects. J Clin Psychopharmacol 20: 455-466
7. Collette F., Van der Linden M. (2002) Brain imaging of the central executive component of working memory. Neurosci Biobehav Rev 26: 105-125
8. Commins D.L., Vosmer G., Virus R.M., Woolverton W.L., Schuster C.R., Seiden L.S. (1987) Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 241: 338-345
9. Croft R.J., Mackay A.J., Mills A T D, Gruzelier J G H (2001) The relative contribution of MDMA and cannabis to cognitive impairment. Psychopharmacology 153: 373-379
10. Dafters R.I., Hoshi R., Talbot A.C. (2004) Contribution of cannabis and MDMA ("ecstasy") to cognitive changes in long-term polydrug users. Psychopharmacology 173: 405-410
11. Daumann J., Fischermann T., Heekeren K., Thron A., Gouzoulis-Mayfrank E. (2004) Neural mechanisms of working memory in ecstasy (MDMA) users who continue or discontinue ecstasy and amphetamine use: evidence from an 18-month longitudinal functional magnetic resonance imaging study. Biol Psychiatry 56: 349-355
12. Daumann J., Fischermann T., Pilatus U., Thron A., Moeller-Hartman W., Gouzoulis-Mayfrank E. (2004) Proton magnetic resonance spectroscopy in ecstasy (MDMA) users. Neurosci Lett 362: 113-116
13. Daumann J., Fischermann T., Heekeren K., Henke K., Thron A., Gouzoulis-Mayfrank E. (2005) Memory-related hippocampal dysfunction in poly-drug ecstasy (3,4-methylenedioxymethamphetamine) users. Psychopharmacology 180: 607-611
14. Ehrenreich H., Rinn T., Kunert H.J., Moeller M.R., Poser W., Schilling L., Gigerenzer G., Hoehe M.R. (1999) Specific attentional disfunction in adults following early start of cannabis use. Psychopharmachology 142: 295-301
15. Fisk J.E., Sharp C.A. (2004) Age-related impairments in executive functioning: updating, inhibition, shifting and access. J Clin Exp Neuropsychol 26: 874-890
16. Fisk J.E., Montgomery C., Murphy P., Wareing M. (2004) Evidence for executive deficits among users of MDMA (Ecstasy). Br J Psychol 95: 457-466
17. Fisk J.E., Montgomery C., Wareing M., Murphy P. (2005) Reasoning deficits in ecstasy (MDMA) polydrug users. Psychopharmacology 181: 550-559
18. Fox H.C., McLean A., Turner J.J., Parrott A.C., Rodgers R., Sahakian B.J. (2002) Neuropsychological evidence of a relatively selective profile of temporal dysfunction drug-free MDMA ("MDMA") polydrug users. Psychopharmacology 162: 203-214
19. Gonzalez R., Vassileva J., Bechara A., Grbesic S., Sworowski L., Novak R.M., Nunnally G., Martin E.M. (2004) Neurocognitive performance of methamphetamine users discordant for history of marijuana exposure. Drug Alcohol Depen 76: 181-190
20. Gouzoulis-Mayfrank E., Daumann J., Tuchtenhagen F., Pelz S., Becker S., Kunert H. -J, Fimm B., Sass H. (2000) Impaired cognitive performance in drug-free recreational MDMA (MDMA) users. J Neurol Neurosurg Psychiatry 68: 719-725
21. Gouzoulis-Mayfrank (2000)
22. Gouzoulis-Mayfrank E., Thimm B., Rezk M., Hensen G., Daumann J. (2003) Memory impairment suggests hippocampal dysfunction in abstinent MDMA users. Progress in Neuro-Psychopharmacollogy and Biological Psychiatry 27: 819-827
23. Gouzoulis-Mayfrank E., Fischermann T., Rezk M., Thimm B., Hensen G., Daumann J. (2005) Memory performance in polyvalent MDMA (ecstasy) users who continue or discontinue MDMA use. Drug Alcohol Depend 78: 317-323
24. Gouzoulis-Mayfrank E., Daumann J. (2006) The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview. J Psychopharmacol 20: 188-193
25. Green A.R., Mechan A.O., Elliott J.M., O'Shea E., Colado M.I. (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "MDMA"). Pharmacol Rev 55: 463-508
26. Hanson K.L., Luciana M. (2004) Neurocognitive function in users of MDMA: the importance of clinically significant patterns of use. Psychol Med 34: 229-246
27. Hatzidimitriou G., McCann U.D., Ricaurte G.A. (1999) Altered serotonin innervation patterns in the forebrain of monkeys treated with (±) 3,4 methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery. J Neurosci 19: 5096-5107
28. Hefferman T.M., Jarvis H., Rodgers J., Scholey A.B., Ling J. (2001) Prospective memory, everyday cognitive failure and central executive function in recreational users of ectsasy. Hum Psychopharmacol 16: 607-612
29. Hochberg Y., Tamhane A. (1987) Multiple Comparison Procedures. John Wiley and Sons
30. Lamers C. T J, Bechara A., Rizzo M., Ramaekers J.G. (2006) Cognitive function and mood in MDMA/THC users, TJC users and non-drug using controls. J Psychopharmacol 20: 302-311
31. McCann U.D., Szabo Z., Seckin E., Rosenblatt P., Mathews W.B., Ravert H.T., Dannals R.F., Ricaurte G.A. (2005) Quantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASB. Neuropsychopharmacology 30: 1741-1750
32. McCardle K., Luebbers S., Carter J.D., Croft R.J., Stough C. (2004) Chronic MDMA (ecstasy) use, cognition and mood. Psychopharmacology 173: 434-439
33. Medina K.L., Shear P.K., Corcoran K. (2005) Ecstasy (MDMA) exposure and neuropsychological functioning: a polydrug perspective. J Int Neuropsychol Soc 11: 753-765
34. Miller J. (1990) Discreteness and continuity in models of human information processing. Acta Psychol (Amst) 74: 297-318
35. Miyake A., Friedman N.P., Emerson M.J., Witzky A.H., Howerther A. (2000) The unity and diversity of executive function and their contribution to complex frontal lobe tasks: a latent variable analysis. Cognit Psychol 41: 49-100
36. Moeller, Steinberg J.L., Dougherty D.M., Narayana P.A., Kramer L.A., Renshaw P.F. (2004) Functional MRI study of working memory in MDMA users. Psychopharmacology 177: 185-194
37. Montgomery C., Fisk J.E., Newcombe R., Murphy P.N. (2005) The differential effects of ecstasy/polydrug use on executive components: shifting, inhibition, updating and access to semantic memory. Psychopharmacology 182: 262-276
38. Morgan M.J. (1998) Recreational use of MDMA (MDMA) is associated with elevated impulsivity. Neuropsychopharmacology 19: 252-264
39. Morgan M.J., McFie L., Fleetwood L.H., Robinson J.A. (2002) Ecstasy (MDMA). are the psychological problems associated with its use reversed by prolonged abstinence? Psychopharmacology (Berl) 159: 294-303
40. Morgan M.J. (2000) MDMA (MDMA). a review of its possible persistent psychological effects. Psychopharmacology 141: 30-36
41. Otto M.W., Bruder G.E., Fava M., Delis D.C., Quitkin F.M., Rosenbaum J.F. (1994) Norms for depressed patients for the California verbal learning test: associations with depression severity and self-report of cognitive difficulties. Arch Clin Neuropsychol 9: 81-88
42. Parrott A.C. (2001) Human psychopharmacology of MDMA (MDMA). a review of 15 years empirical research. Hum Psychopharmacol Clin Exp 16: 557-577
43. Pope H.G., Gruber A.J., Hudson J.I., Cohane G., Huestis M.A., Yurgelun-Todd D. (2003) Early-onset cannabis use and cognitive deficits: what is the nature of the association? Drug Alcohol Depend 69: 303-310
44. Quednow B.B., Jessen F., Kuhn K.U., Maier W., Daum I., Wagner M. (2006) (a) Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction. J Psychopharmacol 20: 373-384
45. Quednow B.B., Kuhn K.U., Hoppe C., Westheide J., Maier W., Wagner M. (2006) (b) Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA ("Ecstasy"). Psychopharmacology 20: 1-14
46. Ramier A.M., Hecaen H. (1970) Respective roles of frontal lesions and lesion lateralization in "verbal fluency" deficiencies. Rev Neurol 123: 17-22
47. Ramier A.M., Hecaen H. (1977) Deficitis in the "verbal fluency" test in left-handed subject with unilateral hemispheric lesions. Rev Neurol 133: 571-574
48. Reay J.L., Hamilton C., Kennedy D.O., Scholey A.B. (2006) MDMA polydrug users show process-specific central executive impairments coupled with impaired social and emotional judgment processes. J Psychopharmacol 20: 385-388
49. Reneman L., Booij J., Schmand B., Van den Brink W., Gunning B. (2000) Memory disturbances in ecstasy users are correlated with an altered brain serotonin neurotransmission. Psychopharmacology 148: 322-324
50. Ricaurte G.A., Forno L.S., Wilson M.A., DeLanney L.E., Irwin I., Moliver M.E., Langston J.W. (1988) (±) 3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates. JAMA 260: 51-55
51. Ricaurte G.A., Yuan J., McCann U.D. (2000) (±)-3,4- methylenedioxymethamphetamine (MDMA, "MDMA")-induced serotonin neuro-toxicity: studies in animals. Neuropsychobiology 42: 5-10
52. Rodgers J. (2000) Cognitive performance amongst recreational users of MDMA. Psychopharmacology 151: 19-24
53. Semple D.M., Ebmeier K.P., Glubus M.F., Ó Carroll R.F., Johnsione F.C. (1999) Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ("ecstasy") users. Br J Psychiatry 175: 63-69
54. Shallice T. (1982) Specific impairments of planning. Philos Trans R Soc Lond B Biol Sci 25 ; 298: 199-209
55. Simon N.G., Mattick R.P. (2002) The impact of regular ecstasy use on memory function. Addiction 97: 1523-1529
56. Smith R.A. (1982) Symbol Digit Modalities Test (SDMT). manual (revised). Los Angeles: Western Psychological Services
57. Stuss D.T., Alexander M.P., Shallice T., Picton T.W., Binns M.A., Macdonald R., Borowiec A., Katz D.I. (2005) Multiple frontal systems controlling response speed. Neuropsychologia 43: 396-417
58. Thomasius R., Peterson K., Buchert R., Andresen B., Zapletalova P., Wartberg L., Nebeling B., Schmoldt A. (2003) Mood, cognition and serotonin transporter availability in current and former ecsatsy (MDMA) users. Psychopharmacology 167: 85-96
59. Thomasius R., Zapletalova P., Petersen K., Buchert R., Andresen B., Wartberg L., Nebeling B., Schmoldt A. (2006) Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective. J Psychopharmacol 20: 211-225
60. Twitchell G.R., Davis M.R., Kalechstein A.D., Newton T.F. (2001) Neurocognitive impairment in MDMA users [Abstract]. MDMA/Ecstasy research: advances, challenges and future directions. Bethesda, MD
61. Verbaten M.N. (2003) Specific memory deficits in ecstasy users? The results of a meta-analysis. Hum Psychopharmacol 18: 281-290
62. Verdejo-García A.J., Lopez-Tordecillas F., Aguilar de Arcos F., Perez García M. (2005) Differential effects of MDMA, cocaine and cannabis use severity on distinctive components of the executive functions in poly-substance users: a multiple regression analysis. Addict Behav 30: 89-101
63. Verkes R.J., Gijsman H.J., Pieters M S M, Schoemaker R.C., Visser S., Kuijpers M., Pennings J.M., Bruin D., Van de Wijngaart G., Van Gerven J M A, Cohen A.F. (2001) Cognitive performance and serotonergic function in users of ecstasy. Psychopharmacology 153: 196-202
64. von Geusau N.A., Staelenhoef P., Huizinga M., Snel J., Ridderinkhof K.R. (2004) Impaired executive function in male MDMA ("MDMA") users. Psychopharmacology 175: 331-341
65. Wareing M., Fisk J.E., Murphy P.N. (2000) Working memory deficits in current and previous users of MDMA ("MDMA"). Br J Psychol 91: 181-188
66. Wareing M., Fisk J.E., Murphy P.N., Montgomery C. (2004) Verbal working memory deficits in current and previous users of MDMA. Human Psychopharmacol 19: 225-234 (a)
67. Wareing M., Murphy P.N., Fisk J.E. (2004) Visuospatial memory impairments in users of MDMA ("MDMA"). Psychopharmacology 173: 391-397 (b)
68. Wareing M., Fisk J.E., Murphy P.N., Montgomery C. (2005) Visuo-spatial working memory deficits in current and former users of MDMA ("ecstasy" ). Hum Psychopharmacol 20: 115-123
69. Wechsler D. (1997) WAIS-III & WMS-III technical manual. San Antonio: The Psychological Corporation
70. Wendt P.E., Risberg J. (2001) Ethanol reduces rCFB activation of left dorsolateral prefrontal cortex during a verbal fluency task. Brain Lang 77: 197-215
71. Zakzanis K.K., Young D.A. (2001) Executive function in abstinent MDMA ("ecstasy") users. Med Sci Monit 7: 1292-1298