Switching genes on and off in haemopoiesis

Biochemical Society Transactions

Volumn 36, Issue 4, 2008, Pages 613-618

  Garrick, David ^a   de Gobbi, Marco ^a   Lynch, Magnus ^a   Higgs, Douglas R ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

globin; Gene switching; Haemopoiesis; Stem cell; Transcriptional regulation

Indexed keywords

ALPHA GLOBIN; DNA; HISTONE DEACETYLASE;

ARTICLE; CELL DIFFERENTIATION; DEVELOPMENTAL STAGE; DNA SEQUENCE; ERYTHROID CELL; GENE CLUSTER; GENE EXPRESSION; GENE LOCUS; GENE REPRESSION; GENETIC REGULATION; HEMATOPOIESIS; HETEROCHROMATIN; HUMAN; MAMMAL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; ERYTHROID CELLS; GLOBINS; HEMATOPOIESIS; HUMANS; PROTEIN BINDING; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 49349091756     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360613     Document Type: Article

References (20)

1. Aiba, K., Sharov, A.A., Carter, M.G., Foroni, C., Vescovi, A.L. and Ko, M.S. (2006) Defining a developmental path to neural fate by global expression profiling of mouse embryonic stem cells and adult neural stem/ progenitor cells. Stem Cells 24, 889-895
2. Komof, M., Guller, S., Baldus, C.D., de Vos, S., Hoelzef, D., Ottmann, O.G. and Hofmann, W.K. (2005) Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation. Stem Cells 23, 1154-1169
3. Synnergren, J., Adak, S., Englund, M.C., Giesler, T.L., Noaksson, K., Lindahl, A., Nilsson, P., Nelson, D., Abbot, S., Olsson, B. and Sartipy, P. (2008) Cardiomyogenic gene expression profiling of differentiating human embryonic stem cells. J. Biotechnol. 134, 162-170
4. Bryder, D., Rossi, D.J. and Weissman, I.L. (2006) Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am. J. Pathol. 169, 338-346
5. Hughes, J.R., Cheng, J.F., Ventress, N., Prabhakar, S., Clark, K., Anguita, E., De Gobbi, M., de Jong, P., Rubin, E. and Higgs, D.R. (200S) Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences. Proc. Natl. Acad. Sci. U.S.A. 102, 9830-9835
6. Wallace, H.A., Marques-Kranc, F., Richardson, M., Luna-Crespo, F., Sharpe, J.A., Hughes, J., Wood, W.G., Higgs, D.R. and Smith, A.J. (2007) Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell 128, 197-209
7. Anguita, E., Hughes, J., Heyworth, C., Blobel, G.A., Wood, W.G. and Higgs, D.R. (2004) Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J. 23, 2841-2852
8. Vernimmen, D., De Gobbi, M., Sloane-Stanley, J.A., Wood, W.G. and Higgs, D.R. (2007) Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression. EMBO J. 26, 2041-2051
9. De Gobbi, M., Anguita, F., Hughes, J., Sloane-Stanley, J.A., Sharpe, J.A., Koch, C.M,, Dunham, I., Gibbons, R.J., Wood, W.G. and Higgs, D.R. (2007) Tissue-specific histone modification and transcription factor binding in alpha globin gene expression. Blood 110, 4503-4510
10. Higgs, D.R., Vernimmen, D., De Gobbi, M., Anguita, E., Hughes, J., Buckle, V., Iborra, F., Garrick, D. and Wood, W.G. (2006) How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation. Biochem. Soc. Symp. 73, 11-22
11. Smith, Z.E. and Higgs, D.R. (1999) The pattern of replication at a human telomeric region (16p13.3): its relationship to chromosome structure and gene expression. Hum. Mol. Genet. 8, 1373-1386
12. Brown, K.E., Amoils, S., Horn, J.M., Buckle, V.J., Higgs, D.R., Merkenschlager, M. and Fisher, A.G. (2001) Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells, Nat. Cell Biol. 3, 602-606
13. Higgs, D.R., Sharpe, J.A. and Wood, W.G. (1998) Understanding α globin gene expression: a step towards effective gene therapy. Semin. Hematol. 35, 93-104
14. Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P. and Reinberg, D. (2002) Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16, 2893-2905
15. Pasini, D., Bracken, A.P., Jensen, M.R., Lazzerini Denchi, E. and Helin, K. (2004) Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23, 4061-4071
16. Sparmann, A. and van Lohuizen, M. (2006) Polycomb silencers control cell fate, development and cancer. Nat. Rev. Cancer 6, 846-856
17. Vire, F., Brenner, C., Deplus, R., Blanchon, L., Fraga, M., Didelot, C., Morey, L,, Van Eynde, A., Bernard, D., Vanderwinden, J.M. et al. (2006) The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439, 871-874
18. van der Vlag, J. and Otte, A.P. (1999) Transcriptional repression mediated by the human Polycomb-group protein EED involves histone deacetylation. Nat. Genet. 23, 474-478
19. Boyer, L.A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L.A., Lee, T.I., Levine, S.S., Wernig, M., Tajonar, A., Ray, M.K. et al. (2006) Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441, 349-3S3
20. Lee, T.I., Jenner, R.G., Boyer, L.A., Guenther, M.G., Levine, S.S., Kumar, R.M., Chevalier, B., Johnstone, S.E., Cole, M.F., Isono, K. et al. (2006) Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125, 301-313