Creatine supplementation does not improve cognitive function in young adults

Physiology and Behavior

Volumn 95, Issue 1-2, 2008, Pages 130-134

  Rawson, Eric S ^a   Lieberman, Harris R ^b   Walsh, Talia M ^a   Zuber, Sylwia M ^a   Harhart, Jaclyn M ^a   Matthews, Tracy C ^a  

^a BLOOMSBURG UNIVERSITY   (United States)

^b U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

Author keywords

Brain; Cognitive; Creatine monohydrate; Ergogenic aid; Phosphocreatine; Psychomotor

Indexed keywords

CREATINE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; REACTION TIME; RECALL; SLEEP DEPRIVATION;

EID: 49349087841     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2008.05.009     Document Type: Article

References (30)

1. Rango M., Castelli A., and Scarlato G. Energetics of 3.5 s neural activation in humans: a 31P MR spectroscopy study. Magn Reson Med 38 (1997) 878-883
2. Sappey-Marinier D., Calabrese G., Fein G., Hugg J.W., Biggins C., and Weiner M.W. Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy. J Cereb Blood Flow Metab 12 (1992) 584-592
3. Harris R.C., Söderlund K., and Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Colch) 83 (1992) 367-374
4. Hultman E., Söderlund K., Timmons J.A., Cederblad G., and Greenhaff P.L. Muscle creatine loading in men. J Appl Physiol 81 (1996) 232-237
5. Dechent P., Pouwels P.J., Wilken B., Hanefeld F., and Frahm J. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol 277 (1999) R698-R704
6. Lyoo I.K., Kong S.W., Sung S.M., Hirashima F., Parow A., Hennen J., et al. Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate. Psychiatry Res 123 (2003) 87-100
7. Pan J.W., and Takahashi K. Cerebral energetic effects of creatine supplementation in humans. Am J Physiol Regul Integr Comp Physiol 292 (2007) R1745-R1750
8. Rawson E.S., and Clarkson P.M. Scientifically debatable: is creatine worth its weight?. Gatorade Sports Science Exchange 16 (2004) 1-6
9. Branch J.D. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab 13 (2003) 198-226
10. Kreider R.B. Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem. 244 (2003) 89-94
11. Rawson E.S., and Persky A.M. Mechanisms of muscular adaptations to creatine supplementation. Int SportMed J 8 (2007) 43-53
12. McMorris T., Harris R.C., Howard A.N., Langridge G., Hall B., Corbett J., et al. Creatine supplementation, sleep deprivation, cortisol, melatonin and behavior. Physiol Behav 90 (2007) 21-28
13. McMorris T., Harris R.C., Swain J., Corbett J., Collard K., Dyson R.J., et al. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl) (2006) 1-11
14. Rae C., Digney A.L., McEwan S.R., and Bates T.C. Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. Proc R Soc Lond B Biol Sci 270 (2003) 2147-2150
15. Watanabe A., Kato N., and Kato T. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neurosci Res 42 (2002) 279-285
16. McMorris T., Mielcarz G., Harris R.C., Swain J.P., and Howard A. Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14 (2007) 517-528
17. Wilkinson I.D., Mitchel N., Breivik S., Greenwood P., Griffiths P.D., Winter E.M., et al. Effects of creatine supplementation on cerebral white matter in competitive sportsmen. Clin J Sport Med 16 (2006) 63-67
18. Steenge G.R., Simpson E.J., and Greenhaff P.L. Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. J Appl Physiol 89 (2000) 1165-1171
19. Persky A.M., Hochhaus G., and Brazeau G.A. Validation of a simple liquid chromatography assay for creatine suitable for pharmacokinetic applications, determination of plasma protein binding and verification of percent labeled claim of various creatine products. J Chromatogr B Anal Technol Biomed Life Sci 794 (2003) 157-165
20. Jones W.P., Loe S.A., Krach S.K., Rager R.Y., and Jones H.M. Automated Neuropsychological Assessment Metrics (Anam) and Woodcock-Johnson Iii Tests of Cognitive Ability: A Concurrent Validity Study. Clin Neuropsychol (2007) 1-16
21. Kabat M.H., Kane R.L., Jefferson A.L., and DiPino R.K. Construct validity of selected Automated Neuropsychological Assessment Metrics (ANAM) battery measures. Clin Neuropsychol 15 (2001) 498-507
22. Delanghe J., De Slypere J.P., De Buyzere M., Robbrecht J., Wieme R., and Vermeulen A. Normal reference values for creatine, creatinine, and carnitine are lower in vegetarians. Clin Chem 35 (1989) 1802-1803
23. Maccormick V.M., Hill L.M., Macneil L., Burke D.G., and Smith-Palmer T. Elevation of creatine in red blood cells in vegetarians and nonvegetarians after creatine supplementation. Can J Appl Physiol 29 (2004) 704-713
24. Burke D.G., Chilibeck P.D., Parise G., Candow D.G., Mahoney D., and Tarnopolsky M. Effect of creatine and weight training on muscle creatine and performance in vegetarians. Med Sci Sports Exerc. 35 (2003) 1946-1955
25. Rawson E.S., Clarkson P.M., Price T.B., and Miles M.P. Differential response of muscle phosphocreatine to creatine supplementation in young and old subjects. Acta Physiol Scand. 174 (2002) 57-65
26. Steenge G.R., Lambourne J., Casey A., Macdonald I.A., and Greenhaff P.L. Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. Am J Physiol 275 (1998) E974-E979
27. Preen D., Dawson B., Goodman C., Beilby J., and Ching S. Creatine supplementation: a comparison of loading and maintenance protocols on creatine uptake by human skeletal muscle. Int J Sport Nutr Exerc Metab 13 (2003) 97-111
28. Green A.L., Hultman E., Macdonald I.A., Sewell D.A., and Greenhaff P.L. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 271 (1996) E821-E826
29. Green A.L., Simpson E.J., Littlewood J.J., Macdonald I.A., and Greenhaff P.L. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol Scand 158 (1996) 195-202
30. Valenzuela M.J., Jones M., Wen W., Rae C., Graham S., Shnier R., et al. Memory training alters hippocampal neurochemistry in healthy elderly. NeuroReport 14 (2003) 1333-1337