Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 6, 2008, Pages

  Cui, Jian ^a   Moradkhan, Raman ^a   Mascarenhas, Vernon ^a   Momen, Afsana ^a   Sinoway, Lawrence I ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Autonomic nervous system; Exercise pressor reflex; Muscle afferents; Passive exercise; Regional intravenous anesthesia

Indexed keywords

KETOROLAC; KETOROLAC TROMETAMOL; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; THROMBOXANE B2;

ADULT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; ENZYME INHIBITION; EXERCISE; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MEAN ARTERIAL PRESSURE; MECHANORECEPTOR; MUSCLE ISCHEMIA; MUSCLE STRETCHING; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SYMPATHETIC TONE; ADRENERGIC SYSTEM; CLINICAL TRIAL; DRUG EFFECT; HAND STRENGTH; INFUSION; INNERVATION; ISCHEMIA; METABOLISM; MUSCLE SPINDLE; MYOTATIC REFLEX; PATHOPHYSIOLOGY; SKELETAL MUSCLE; VASCULARIZATION;

ADULT; BLOOD PRESSURE; CYCLOOXYGENASE INHIBITORS; EXERCISE; FEMALE; HAND STRENGTH; HEART RATE; HUMANS; INFUSIONS, PARENTERAL; ISCHEMIA; KETOROLAC TROMETHAMINE; MALE; MUSCLE SPINDLES; MUSCLE, SKELETAL; PROSTAGLANDINS; REFLEX, STRETCH; SYMPATHETIC NERVOUS SYSTEM; THROMBOXANE B2;

EID: 49249129761     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.91505.2007     Document Type: Article

References (45)

1. Adreani CM, Hill JM, Kaufman MP. Responses of group III and IV muscle afferents to dynamic exercise. J Appl Physiol 82: 1811-1817, 1997.
2. Adreani CM, Kaufman MP. Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise. J Appl Physiol 84: 1827-1833, 1998.
3. Batman BA, Hardy JC, Leuenberger UA, Smith MB, Yang QX, Sinoway LI. Sympathetic nerve activity during prolonged rhythmic forearm exercise. J Appl Physiol 76: 1077-1081, 1994.
4. Baum K, Selle K, Leyk D, Essfeld D. Comparison of blood pressure and heart rate responses to isometric exercise and passive muscle stretch in humans. Eur J Appl Physiol Occup Physiol 70: 240-245, 1995.
5. Bell MP, White MJ. Cardiovascular responses to external compression of human calf muscle vary during graded metaboreflex stimulation. Exp Physiol 90: 383-391, 2005.
6. Chapleau MW, Hajduczok G, Abboud FM. Paracrine role of prostanoids in activation of arterial baroreceptors: an overview. Clin Exp Hypertens A 13: 817-824, 1991.
7. Chen HI, Chapleau MW, McDowell TS, Abboud FM. Prostaglandins contribute to activation of baroreceptors in rabbits. Possible paracrine influence of endothelium. Circ Res 67: 1394-1404, 1990.
8. Cryer B, Feldman M. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med 104: 413-421, 1998.
9. Cui J, Blaha C, Moradkhan M, Gray K, Sinoway L. Muscle sympathetic nerve activity responses to dynamic passive muscle stretch in humans. J Physiol 576: 625-634, 2006.
10. Cui J, Mascarenhas V, Moradkhan R, Blaha C, Sinoway LI. Effects of muscle metabolites on responses of muscle sympathetic nerve activity to mechanoreceptor(s) stimulation in healthy humans. Am J Physiol Regul Integr Comp Physiol 294: R458-R466, 2008.
11. Cui J, McQuillan P, Momen A, Blaha C, Moradkhan R, Mascarenhas V, Hogeman CS, Krishnan A, Sinoway LI. The role of the cyclooxygenase products in evoking sympathetic activation in exercise. Am J Physiol Heart Circ Physiol 293: H1861-H1868, 2007.
12. Cui J, Zhang R, Wilson TE, Crandall CG. Spectral analysis of muscle sympathetic nerve activity in heat-stressed humans. Am J Physiol Heart Circ Physiol 286: H1101-H1106, 2004.
13. Doerzbacher KJ, Ray CA. Muscle sympathetic nerve responses to physiological changes in prostaglandin production in humans. J Appl Physiol 90: 624-629, 2001.
14. Fisher JP, Bell MP, White MJ. Cardiovascular responses to human calf muscle stretch during varying levels of muscle metaboreflex activation. Exp Physiol 90: 773-781, 2005.
15. Fontana GA, Pantaleo T, Bongianni F, Cresci F, Lavorini F, Guerra CT, Panuccio P. Prostaglandin synthesis blockade by ketoprofen attenuates respiratory and cardiovascular responses to static handgrip. J Appl Physiol 78: 449-457, 1995.
16. Hayes SG, Kaufman MP. Gadolinium attenuates exercise pressor reflex in cats. Am J Physiol Heart Circ Physiol 280: H2153-H2161, 2001.
17. Hayes SG, Kaufman MP. MLR stimulation and exercise pressor reflex activate different renal sympathetic fibers in decerebrate cats. J Appl Physiol 92: 1628-1634, 2002.
18. Hayes SG, Kindig AE, Kaufman MP. Comparison between the effect of static contraction and tendon stretch on the discharge of group III and IV muscle afferents. J Appl Physiol 99: 1891-1896, 2005.
19. Hayes SG, Kindig AE, Kaufman MP. Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats. Am J Physiol Heart Circ Physiol 290: H2239-H2246, 2006.
20. Herr MD, Imadojemu V, Kunselman AR, Sinoway LI. Characteristics of the muscle mechanoreflex during quadriceps contractions in humans. J Appl Physiol 86: 767-772, 1999.
21. Hill JM, Adreani CM, Kaufman MP. Muscle reflex stimulates sympathetic postganglionic efferents innervating triceps surae muscles of cats. Am J Physiol Heart Circ Physiol 271: H38-H43, 1996.
22. Kaufman MP, Longhurst JC, Rybicki KJ, Wallach JH, Mitchell JH. Effects of static muscular contraction on impulse activity of group III and IV afferents in cats. J Appl Physiol 55: 105-112, 1983.
23. Kaufman MP, Rybicki KJ. Discharge properties of group III and IV muscle afferents: their responses to mechanical and metabolic stimuli. Circ Res 61: I60-I65, 1987.
24. Kaufman MP, Rybicki KJ, Waldrop TG, Ordway GA. Effect of ischemia on responses of group III and IV afferents to contraction. J Appl Physiol 57: 644-650, 1984.
25. Li J, Sinoway A, Gao Z, Maile M, Pu M, Sinoway L. Muscle mechanoreflex and metaboreflex responses after myocardial infarction in rats. Circulation 110: 3049-3054, 2004.
26. Li J, Sinoway LI. ATP stimulates chemically sensitive and sensitizes mechanically sensitive afferents. Am J Physiol Heart Circ Physiol 283: H2636-H2643, 2002.
27. Mark AL, Victor RG, Nerhed C, Wallin BG. Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res 57: 461-469, 1985.
28. McCloskey DI, Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol (Lond) 224: 173-186, 1972.
29. Mense S, Meyer H. Bradykinin-induced modulation of the response behaviour of different types of feline group III and IV muscle receptors. J Physiol (Lond) 389: 49-63, 1988.
30. Middlekauff HR, Chiu J. Cyclooxygenase products sensitize muscle mechanoreceptors in healthy humans. Am J Physiol Heart Circ Physiol 287: H1944-H1949, 2004.
31. Momen A, Cui J, McQuillan P, Sinoway LI. Local prostaglandin blockade attenuates muscle mechanoreflex mediated renal vasoconstriction during muscle stretch in humans. Am J Physiol Heart Circ Physiol 294: 2184-2190, 2008.
32. Monahan KD, Ray CA. Cyclooxygenase inhibition and baroreflex sensitivity in humans. Am J Physiol Heart Circ Physiol 288: H737-H743, 2005.
33. Ragan BG, Nelson AJ, Bell GW, Iwamoto GA. Salicylate-based analgesic balm attenuates pressor responses from skeletal muscle. Med Sci Sports Exerc 39: 1942-1948, 2007.
34. Rotto DM, Hill JM, Schultz HD, Kaufman MP. Cyclooxygenase blockade attenuates responses of group IV muscle afferents to static contraction. Am J Physiol Heart Circ Physiol 259: H745-H750, 1990.
35. Rotto DM, Kaufman MP. Effect of metabolic products of muscular contraction on discharge of group III and IV afferents. J Appl Physiol 64: 2306-2313, 1988.
36. Rotto DM, Schultz HD, Longhurst JC, Kaufman MP. Sensitization of group III muscle afferents to static contraction by arachidonic acid. J Appl Physiol 68: 861-867, 1990.
37. Rowell LB, O'Leary DS. Reflex control of the circulation during exercise: chemoreflexes and mechanoreflexes. J Appl Physiol 69: 407-418, 1990.
38. Smith WL. Prostanoid biosynthesis and mechanisms of action. Am J Physiol Renal Fluid Electrolyte Physiol 263: F181-F191, 1992.
39. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69: 145-182, 2000.
40. Stebbins CL, Brown B, Levin D, Longhurst JC. Reflex effect of skeletal muscle mechanoreceptor stimulation on the cardiovascular system. J Appl Physiol 65: 1539-1547, 1988.
41. Stebbins CL, Maruoka Y, Longhurst JC. Prostaglandins contribute to cardiovascular reflexes evoked by static muscular contraction. Circ Res 59: 645-654, 1986.
42. Vallbo AB, Hagbarth KE, Torebjörk HE, Wallin BG. Somatosensory, proprioceptive and sympathetic activity in human peripheral nerves. Physiol Rev 59: 919-957, 1979.
43. Victor RG, Rotto DM, Pryor SL, Kaufman MP. Stimulation of renal sympathetic activity by static contraction: evidence for mechanoreceptor-induced reflexes from skeletal muscle. Circ Res 64: 592-599, 1989.
44. Waldrop TG, Rybicki KJ, Kaufman MP, Ordway GA. Activation of visceral thin-fiber afferents increases respiratory output in cats. Respir Physiol 58: 187-196, 1984.
45. Wilson JR, Kapoor SC. Contribution of prostaglandins to exercise-induced vasodilation in humans. Am J Physiol Heart Circ Physiol 265: H171-H175, 1993.