Evaluation of Nε-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy

Diabetologia

Volumn 51, Issue 9, 2008, Pages 1723-1730

  Zhang, X ^a   Lai, Y ^a   McCance, D R ^b   Uchida, K ^c   McDonald, D M ^a   Gardiner, T A ^a   Stitt, A W ^a   Curtis, T M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ROYAL VICTORIA HOSPITAL   (United Kingdom)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

Acrolein; Advanced lipoxidation end products; Diabetic retinopathy; FDP lysine; Haemoglobin; Oxidative stress; Serum

Indexed keywords

BIOLOGICAL MARKER; HEMOGLOBIN; HEMOGLOBIN A1C; LYSINE DERIVATIVE; N EPSILON (3 FORMYL 3,4 DEHYDROPIPERIDINO)LYSINE; DRUG DERIVATIVE; LYSINE; MONOCLONAL ANTIBODY; N(EPSILON) (3 FORMYL 3,4 DIHYDROPIPERIDINO)LYSINE; N(EPSILON)-(3-FORMYL-3,4-DIHYDROPIPERIDINO)LYSINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK FACTOR; STATISTICAL SIGNIFICANCE; BLOOD; CAUCASIAN; CLASSIFICATION; HOSPITALIZATION; HYPERGLYCEMIA; PATHOPHYSIOLOGY; REFERENCE VALUE;

ANTIBODIES, MONOCLONAL; BIOLOGICAL MARKERS; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; HYPERGLYCEMIA; LYSINE; REFERENCE VALUES; SEVERITY OF ILLNESS INDEX;

EID: 49249091368     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-1071-3     Document Type: Article

References (47)

1. LP Aiello TW Gardner GL King 1998 Diabetic retinopathy Diabetes Care 21 143 156
2. R Klein BE Klein SE Moss 1989 The Wisconsin epidemiological study of diabetic retinopathy: a review Diabetes Metab Rev 5 559 570
3. Anonymous 1993 The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group N Engl J Med 329 977 986
4. Anonymous 1998 Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group Lancet 352 837 853
5. RA Kowluru PS Chan 2007 Oxidative stress and diabetic retinopathy Exp Diabetes Res 2007 43603
6. T Nishikawa D Edelstein XL Du 2000 Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Nature 404 787 790
7. RA Kowluru TS Kern RL Engerman 1997 Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system Free Radic Biol Med 22 587 592
8. W Li M Yanoff B Jian Z He 1999 Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas Cell Mol Biol (Noisy-le-grand) 45 59 66
9. Y Taniyama KK Griendling 2003 Reactive oxygen species in the vasculature: molecular and cellular mechanisms Hypertension 42 1075 1081
10. Y Du CM Miller TS Kern 2003 Hyperglycemia increases mitochondrial superoxide in retina and retinal cells Free Radic Biol Med 35 1491 1499
11. RA Kowluru SN Abbas 2003 Diabetes-induced mitochondrial dysfunction in the retina Invest Ophthalmol Vis Sci 44 5327 5334
12. RA Kowluru S Odenbach 2004 Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats Diabetes 53 3233 3238
13. RA Kowluru J Tang TS Kern 2001 Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy Diabetes 50 1938 1942
14. M Kanwar PS Chan TS Kern RA Kowluru 2007 Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase Invest Ophthalmol Vis Sci 48 3805 3811
15. RA Kowluru V Kowluru Y Xiong YS Ho 2006 Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress Free Radic Biol Med 41 1191 1196
16. HP Hammes M Brownlee J Lin E Schleicher RG Bretzel 1999 Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product Nepsilon-(carboxymethyl) lysine independently of glycohaemoglobin concentrations Diabetologia 42 603 607
17. L Monnier E Mas C Ginet 2006 Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes JAMA 295 1681 1687
18. K Uhlmann P Kovacs Y Boettcher HP Hammes R Paschke 2006 Genetics of diabetic retinopathy Exp Clin Endocrinol Diabetes 114 275 294
19. SE Hofer B Bennetts AK Chan 2006 Association between PON 1 polymorphisms, PON activity and diabetes complications J Diabetes Complications 20 322 328
20. MG Petrovic T Kunej B Peterlin P Dovc D Petrovic 2005 Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gamma coactivator-1 gene might be a risk factor for diabetic retinopathy in Slovene population (Caucasians) with type 2 diabetes and the Pro12Ala polymorphism of the PPARgamma gene is not Diabetes Metab Res Rev 21 470 474
21. ME Hartnett RD Stratton RW Browne BA Rosner RJ Lanham D Armstrong 2000 Serum markers of oxidative stress and severity of diabetic retinopathy Diabetes Care 23 234 240
22. K Uchida 2000 Role of reactive aldehyde in cardiovascular diseases Free Radic Biol Med 28 1685 1696
23. K Uchida M Kanematsu Y Morimitsu T Osawa N Noguchi E Niki 1998 Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins J Biol Chem 273 16058 16066
24. E Noiri S Yamada A Nakao 2002 Serum protein acrolein adducts: utility in detecting oxidant stress in hemodialysis patients and reversal using a vitamin E-bonded hemodialyzer Free Radic Biol Med 33 1651 1656
25. M Daimon K Sugiyama W Kameda 2003 Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes Endocr J 50 61 67
26. H Tsukahara K Sekine M Uchiyama 2003 Formation of advanced glycosylation end products and oxidative stress in young patients with type 1 diabetes Pediatr Res 54 419 424
27. K Uchida M Kanematsu K Sakai 1998 Protein-bound acrolein: potential markers for oxidative stress Proc Natl Acad Sci USA 95 4882 4887
28. R Klein BE Klein SE Moss KJ Cruickshanks 1998 The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes Ophthalmology 105 1801 1815
29. K Shotliff G Duncan 2006 Diabetic retinopathy: summary of grading and management criteria Pract Diab Int 23 418 420
30. M Porta AK Sjoelie N Chaturvedi 2001 Risk factors for progression to proliferative diabetic retinopathy in the EURODIAB Prospective Complications Study Diabetologia 44 2203 2209
31. L Zhang G Krzentowski A Albert PJ Lefebvre 2001 Risk of developing retinopathy in Diabetes Control and Complications Trial type 1 diabetic patients with good or poor metabolic control Diabetes Care 24 1275 1279
32. PL Skipper SR Tannenbaum 1990 Protein adducts in the molecular dosimetry of chemical carcinogens Carcinogenesis 11 507 518
33. TH Maugh 1975 Hemoglobin: model systems shed light on oxygen binding Science 187 154 156
34. SM Garn AS Ryan GM Owen S Abraham 1981 Income matched black-white hemoglobin differences after correction for low transferrin saturations Am J Clin Nutr 34 1645 1647
35. T Skjelbakken B Langbakk IM Dahl ML Lochen 2005 Haemoglobin and anaemia in a gender perspective: the Tromso Study Eur J Haematol 74 381 388
36. R Yip C Johnson PR Dallman 1984 Age-related changes in laboratory values used in the diagnosis of anemia and iron deficiency Am J Clin Nutr 39 427 436
37. RA Kowluru P Koppolu 2002 Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy Free Radic Res 36 993 999
38. A Tanel DA verill-Bates 2007 Activation of the death receptor pathway of apoptosis by the aldehyde acrolein Free Radic Biol Med 42 798 810
39. A Tanel DA verill-Bates 2005 The aldehyde acrolein induces apoptosis via activation of the mitochondrial pathway Biochim Biophys Acta 1743 255 267
40. G Aldini I le-Donne RM Facino A Milzani M Carini 2007 Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls Med Res Rev 27 817 868
41. 1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial Diabetes 44 968 983
42. MX Fu JR Requena AJ Jenkins TJ Lyons JW Baynes SR Thorpe 1996 The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions J Biol Chem 271 9982 9986
43. BO Boehm S Schilling S Rosinger 2004 Elevated serum levels of N(epsilon)-carboxymethyl-lysine, an advanced glycation end product, are associated with proliferative diabetic retinopathy and macular oedema Diabetologia 47 1376 1379
44. J Miura S Yamagishi Y Uchigata 2003 Serum levels of non- carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with type 1 diabetes J Diabetes Complications 17 16 21
45. MP Wautier P Massin PJ Guillausseau 2003 N(carboxymethyl)lysine as a biomarker for microvascular complications in type 2 diabetic patients Diabetes Metab 29 44 52
46. VM Monnier DR Sell S Genuth 2005 Glycation products as markers and predictors of the progression of diabetic complications Ann N Y Acad Sci 1043 567 581
47. S Genuth W Sun P Cleary 2005 Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes Diabetes 54 3103 3111