Tau pathology and neurodegeneration: An obvious but misunderstood link

Journal of Alzheimer's Disease

Volumn 14, Issue 4, 2008, Pages 437-440

  Delacourte, André ^a  

^a JEAN PIERRE AUBERT RESEARCH CENTER   (France)

Author keywords

Alzheimer; Loss of function; Mutation; Neurodegeneration; Phosphorylation; Proteinopathy; Tauopathy; Toxicity

Indexed keywords

TAU PROTEIN;

ALZHEIMER DISEASE; COGNITIVE DEFECT; MUTATION; NERVE CELL NETWORK; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; REVIEW; TAUOPATHY; TRANSGENIC MOUSE;

EID: 49149131122     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2008-14412     Document Type: Review

References (43)

1. A. Alzheimer, Uber eine eigenartige Erkrankung der Hirnrinde., Allg Zeitschr Psychiatr 64 (1907), 146-148.
2. T. Arendt, J. Stieler, A.M. Strijkstra, R.A. Hut, J. Rudiger, E.A. Van der Zee, T. Harkany, M. Holzer and W. Hartig, Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals, J Neurosci 23 (2003), 6972-6981.
3. R.A. Armstrong, P.L. Lantos and N.J. Cairns, Progressive supranuclear palsy (PSP): a quantitative study of the pathological changes in cortical and subcortical regions of eight cases, J Neural Transm 114 (2007), 1569-1577.
4. J. Avila, Tau aggregation into fibrillar polymers: taupathies, FEBS Lett 476 (2000), 89-92.
5. A. Boutajangout, K. Leroy, N. Touchet, M. Authelet, V. Blanchard, G. Tremp, L. Pradier and J.P. Brion, Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1, Neurosci Lett 318 (2002), 29-33.
6. H. Braak and E. Braak, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol (Berl) 82 (1991), 239-259.
7. H. Braak, E. Ghebremedhin, U. Rub, H. Bratzke and K. Del Tredici, Stages in the development of Parkinson's disease-related pathology, Cell Tissue Res 318 (2004), 121-134.
8. H. Braak, U. Rub, C. Schultz and K. Del Tredici, Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases, J Alzheimers Dis 9 (2006), 35-44.
9. J.P. Brion, A.M. Couck, E. Passareiro and J. Flament-Durand, Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study, J Submicrosc Cytol 17 (1985), 89-96.
10. D. Campion, C. Dumanchin, D. Hannequin, B. Dubois, S. Belliard, M. Puel, C. Thomas-Anterion, A. Michon, C. Martin, F. Charbonnier, G. Raux, A. Camuzat, C. Penet, V. Mesnage, M. Martinez, F. Clerget-Darpoux, A. Brice and T. Frebourg, Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum, Am J Hum Genet 65 (1999), 664-670.
11. C. Casas, N. Sergeant, J.M. Itier, V. Blanchard, O. Wirths, N. van der Kolk, V. Vingtdeux, E. van de Steeg, G. Ret, T. Canton, H. Drobecq, A. Clark, B. Bonici, A. Delacourte, J. Benavides, C. Schmitz, G. Tremp, T.A. Bayer, P. Benoit and L. Pradier, Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model, Am J Pathol 165 (2004), 1289-1300.
12. A. Delacourte and A. Defossez, Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments, J Neurol Sci 76 (1986), 173-186.
13. A. Delacourte, J.P. David, N. Sergeant, L. Buee, A. Wattez, P. Vermersch, F. Ghozali, C. Fallet-Bianco, F. Pasquier, F. Lebert, H. Petit and C. Di Menza, The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease, Neurology 52 (1999), 1158-1165.
14. A. Delacourte, N. Sergeant, D. Champain, A. Wattez, C.A. Maurage, F. Lebert, F. Pasquier and J.P. David, Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease, Neurology 59 (2002), 398-407.
15. V. Deramecourt, S. Bombois, C.A. Maurage, A. Ghestem, H. Drobecq, E. Vanmechelen, F. Lebert, F. Pasquier and A. Delacourte, Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies, J Neuropathol Exp Neurol 65 (2006), 278-288.
16. S. Flament and A. Delacourte, Abnormal tau species are produced during Alzheimer's disease neurodegenerating process, FEBS Lett 247 (1989), 213-216.
17. S. Frank, F. Clavaguera and M. Tolnay, Tauopathy models and human neuropathology: similarities and differences, Acta Neuropathol 115 (2008), 39-53.
18. M. Goedert, Neurofibrillary pathology of Alzheimer's disease and other tauopathies, Prog Brain Res 117 (1998), 287-306.
19. I. Grundke-Iqbal, K. Iqbal, M. Quinlan, Y.C. Tung, M.S. Zaidi and H.M. Wisniewski, Microtubule-associated protein tau. A component of Alzheimer paired helical filaments, J Biol Chem 261 (1986), 6084-6089.
20. I. Grundke-Iqbal, K. Iqbal, Y.C. Tung, M. Quinlan, H.M. Wisniewski and L.I. Binder, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology, Proc Natl Acad Sci USA 83 (1986), 4913-4917.
21. G.M. Halliday, V. Macdonald and J.M. Henderson, A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease, Brain 128 (2005), 2272-2280.
22. J. Hardy and D.J. Selkoe, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science 297 (2002), 353-356.
23. H. Houlden, J. Johnson, C. Gardner-Thorpe, T. Lashley, D. Hernandez, P. Worth, A.B. Singleton, D.A. Hilton, J. Holton, T. Revesz, M.B. Davis, P. Giunti and N.W. Wood, Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11, Nat Genet 39 (2007), 1434-1436.
24. K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang and G. Cole, Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice, Science 274 (1996), 99-102.
25. M. Hutton, C.L. Lendon, P. Rizzu, M. Baker, S. Froelich, H. Houlden, S. Pickering-Brown, S. Chakraverty, A. Isaacs, A. Grover, J. Hackett, J. Adamson, S. Lincoln, D. Dickson, P. Davies, R.C. Petersen, M. Stevens, E. de Graaff, E. Wauters, J. van Baren, M. Hillebrand, M. Joosse, J.M. Kwon, P. Nowotny, L.K. Che, J. Norton, J.C. Morris, L.A. Reed, J. Trojanowski, H. Basun, L. Lannfelt, M. Neystat, S. Fahn, F. Dark, T. Tannenberg, P.R. Dodd, N. Hayward, J.B.J.Kwok, P.R. Schofield, A. Andreadis, J. Snowden, D. Craufurd, D. Neary, F. Owen, B.A. Oostra, J. Hardy, A. Goate, J. Van Swieten, D. Mann, T. Lynch and P. Heutink, Association of missense and 5′-splicesite mutations in tau with the inherited dementia FTDP-17, Nature 393 (1998), 702-705.
26. B.T. Hyman and J.Q. Trojanowski, Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease, J Neuropathol Exp Neurol 56 (1997), 1095-1097.
27. Y. Ikeda, K. Ishiguro and S.C. Fujita, Ether stress-induced Alzheimer-like tau phosphorylation in the normal mouse brain, FEBS Lett 581 (2007), 891-897.
28. M. Kidd, Alzheimer's Disease - An Electron Microscopical Study, Brain 87 (1964), 307-320.
29. V.M. Lee, T.K. Kenyon and J.Q. Trojanowski, Transgenic animal models of tauopathies, Biochim Biophys Acta 1739 (2005), 251-259.
30. S. Oddo, A. Caccamo, J.D. Shepherd, M.P. Murphy, T.E. Golde, R. Kayed, R. Metherate, M.P. Mattson, Y. Akbari and F.M. LaFerla, Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction, Neuron 39 (2003), 409-421.
31. S.C. Papasozomenos, The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer disease, Proc Natl Acad Sci USA 94 (1997), 6612-6617.
32. E. Planel, K.E. Richter, C.E. Nolan, J.E. Finley, L. Liu, Y. Wen, P. Krishnamurthy, M. Herman, L. Wang, J.B. Schachter, R.B. Nelson, L.F. Lau and K.E. Duff, Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia, J Neurosci 27 (2007), 3090-3097.
33. E. Planel, Y. Tatebayashi, T. Miyasaka, L. Liu, L. Wang, M. Herman, W.H. Yu, J.A. Luchsinger, B. Wadzinski, K.E. Duff and A. Takashima, Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms, J Neurosci 27 (2007), 13635-13648.
34. V. Rhein and A. Eckert, Effects of Alzheimer's amyloid-beta and tau protein on mitochondrial function - role of glucose metabolism and insulin signalling, Arch Physiol Biochem 113 (2007), 131-141.
35. N. Sahara, J. Lewis, M. DeTure, E. McGowan, D.W. Dickson, M. Hutton and S.H. Yen, Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility, J Neurochem 83 (2002), 1498-1508.
36. C. Schwab, M. Hosokawa and P.L. McGeer, Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease, Exp Neurol 188 (2004), 52-64.
37. N. Sergeant, A. Delacourte and L. Buee, Tau protein as a differential biomarker of tauopathies, Biochim Biophys Acta 1739 (2005), 179-197.
38. J. Shen and R.J. Kelleher, 3rd, The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism, Proc Natl Acad Sci USA 104 (2007), 403-409.
39. M.G. Spillantini, J.R. Murrell, M. Goedert, M.R. Farlow, A. Klug and B. Ghetti, Mutation in the tau gene in familial multiple system tauopathy with presenile dementia, Proc Natl Acad Sci USA 95 (1998), 7737-7741.
40. C. Van den Haute, K. Spittaels, J. Van Dorpe, R. Lasrado, K. Vandezande, I. Laenen, H. Geerts and F. Van Leuven, Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice, Neurobiol Dis 8 (2001), 32-44.
41. P. Vermersch, Y. Robitaille, L. Bernier, A. Wattez, D. Gauvreau and A. Delacourte, Biochemical mapping of neurofibrillary degeneration in a case of progressive supranuclear palsy: evidence for general cortical involvement, Acta Neuropathol 87 (1994), 572-577.
42. X. Zhu, J.Avila, G. Perry and M.A. Smith, Treating the lesions, not the disease, Am J Pathol 170 (2007), 1457-1459.
43. V. Zhukareva, V. Vogelsberg-Ragaglia, V.M. Van Deerlin, J. Bruce, T. Shuck, M. Grossman, C.M. Clark, S.E. Arnold, E. Masliah, D. Galasko, J.Q. Trojanowski and V.M. Lee, Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia, Ann Neurol 49 (2001), 165-175.