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Volumn 3, Issue 2, 2008, Pages 104-108

Tamoxifen as a powerful neuroprotectant in experimental stroke and implications for human stroke therapy

Author keywords

Experimental stroke; Human stroke therapy; Neuroprotectant; Tamoxifen

Indexed keywords

DISUFENTON SODIUM; ESTROGEN RECEPTOR; FULVESTRANT; GLUTAMIC ACID; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; NEUROPROTECTIVE AGENT;

EID: 49149123497     PISSN: 15748898     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488908784534603     Document Type: Article
Times cited : (12)

References (32)
  • 1
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999; 22: 391-397.
    • (1999) Trends Neurosci , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 2
    • 0037224703 scopus 로고    scopus 로고
    • Adventures in the pathophysiology of brain ischemia: Penumbra, gene expression, neuroprotection: The 2002 Thomas Willis lecture
    • Ginsberg MD. Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: The 2002 Thomas Willis lecture. Stroke 2003; 34: 214-223.
    • (2003) Stroke , vol.34 , pp. 214-223
    • Ginsberg, M.D.1
  • 3
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • Lipton P. Ischemic cell death in brain neurons. Physiol Rev 1999; 79: 1431-1568.
    • (1999) Physiol Rev , vol.79 , pp. 1431-1568
    • Lipton, P.1
  • 4
    • 0002444716 scopus 로고    scopus 로고
    • Glutamate receptor-mediated neuronal death in the ischemic brain
    • Choi DW, Lobner D, Dugan LL. Glutamate receptor-mediated neuronal death in the ischemic brain. Monogr. Neural Sci 1998; 16: 2-13.
    • (1998) Monogr. Neural Sci , vol.16 , pp. 2-13
    • Choi, D.W.1    Lobner, D.2    Dugan, L.L.3
  • 6
    • 25144518193 scopus 로고    scopus 로고
    • Why have neuro-protectants failed?: Lessons learned from stroke trials
    • Muir KW, Teal PA. Why have neuro-protectants failed?: Lessons learned from stroke trials. J Neurol 2005; 252: 1011-1020.
    • (2005) J Neurol , vol.252 , pp. 1011-1020
    • Muir, K.W.1    Teal, P.A.2
  • 7
    • 0034698952 scopus 로고    scopus 로고
    • Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion
    • Kimelberg HK, Feustel PJ, Jin Y, et al. Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion. NeuroReport 2000; 11: 2675-2679.
    • (2000) NeuroReport , vol.11 , pp. 2675-2679
    • Kimelberg, H.K.1    Feustel, P.J.2    Jin, Y.3
  • 8
    • 26244450622 scopus 로고    scopus 로고
    • Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemia
    • Zhang Y, Jin Y, Behr MJ, Feustel PJ, Morrison JP, Kimelberg HK. Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemia. Exp Neurol 2005; 196: 41-46.
    • (2005) Exp Neurol , vol.196 , pp. 41-46
    • Zhang, Y.1    Jin, Y.2    Behr, M.J.3    Feustel, P.J.4    Morrison, J.P.5    Kimelberg, H.K.6
  • 9
    • 0037217490 scopus 로고    scopus 로고
    • Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat
    • Mehta SH, Dhandapani KM, De Sevilla LM, Webb RC, Mahesh VB, Brann DW. Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinol 2003; 77: 44-50.
    • (2003) Neuroendocrinol , vol.77 , pp. 44-50
    • Mehta, S.H.1    Dhandapani, K.M.2    De Sevilla, L.M.3    Webb, R.C.4    Mahesh, V.B.5    Brann, D.W.6
  • 10
    • 0032957182 scopus 로고    scopus 로고
    • Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokainate and an anion channel blocker
    • Seki Y, Feustel PJ, Keller RW Jr., Tranmer BI, Kimelberg HK. Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokainate and an anion channel blocker. Stroke 1999; 30: 433-440.
    • (1999) Stroke , vol.30 , pp. 433-440
    • Seki, Y.1    Feustel, P.J.2    Keller Jr., R.W.3    Tranmer, B.I.4    Kimelberg, H.K.5
  • 11
    • 20344374445 scopus 로고    scopus 로고
    • Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy
    • Kimelberg HK. Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy. Glia 2005; 50: 389-397.
    • (2005) Glia , vol.50 , pp. 389-397
    • Kimelberg, H.K.1
  • 12
    • 2142663064 scopus 로고    scopus 로고
    • Volume regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra
    • Feustel PJ, Jin Y, Kimelberg HK. Volume regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra. Stroke 2004; 35: 1164-1168.
    • (2004) Stroke , vol.35 , pp. 1164-1168
    • Feustel, P.J.1    Jin, Y.2    Kimelberg, H.K.3
  • 13
    • 0029758023 scopus 로고    scopus 로고
    • A permanently charged tamoxifen derivative idsplays anticancer activity and improved tissue selectivity in rodents
    • Biegon A, Brewster M, Degani H, Pop E, Somjen D, Kaye AM. A permanently charged tamoxifen derivative idsplays anticancer activity and improved tissue selectivity in rodents. Cancer Res 1996; 56: 4328-4331.
    • (1996) Cancer Res , vol.56 , pp. 4328-4331
    • Biegon, A.1    Brewster, M.2    Degani, H.3    Pop, E.4    Somjen, D.5    Kaye, A.M.6
  • 14
    • 33947534438 scopus 로고    scopus 로고
    • Pharmacokinetics of tamoxifen after intravenous and oral dosing of tamoxifenhydroxybutenyl-beta-cyclodextrin formulations
    • Buchanan CM, Buchanan NL, Edgar KJ, et al. Pharmacokinetics of tamoxifen after intravenous and oral dosing of tamoxifenhydroxybutenyl-beta-cyclodextrin formulations. J Pharm Sci 2007; 96: 644-660.
    • (2007) J Pharm Sci , vol.96 , pp. 644-660
    • Buchanan, C.M.1    Buchanan, N.L.2    Edgar, K.J.3
  • 15
    • 0037970171 scopus 로고    scopus 로고
    • Neuroprotective activity of tamoxifen in permanent focal ischemia
    • Kimelberg HK, Jin Y, Feustel PJ. Neuroprotective activity of tamoxifen in permanent focal ischemia. J Neurosurgery 2003; 99: 138-142.
    • (2003) J Neurosurgery , vol.99 , pp. 138-142
    • Kimelberg, H.K.1    Jin, Y.2    Feustel, P.J.3
  • 16
    • 0021707433 scopus 로고
    • Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • Benveniste H, Drejer J, Schousboe A, Diemer NM. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 1984; 43: 1369-1374.
    • (1984) J Neurochem , vol.43 , pp. 1369-1374
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3    Diemer, N.M.4
  • 17
    • 0345118252 scopus 로고    scopus 로고
    • Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059
    • Green AR, Ashwood T, Odergren T, Jackson DM. Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059. Pharmacol Ther 2003; 100: 195-214.
    • (2003) Pharmacol Ther , vol.100 , pp. 195-214
    • Green, A.R.1    Ashwood, T.2    Odergren, T.3    Jackson, D.M.4
  • 18
    • 0035106245 scopus 로고    scopus 로고
    • Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat
    • Osuka K, Feustel PJ, Mongin AA, Tranmer BI, Kimelberg HK. Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat. J Neurochem 2001; 76: 1842-1850.
    • (2001) J Neurochem , vol.76 , pp. 1842-1850
    • Osuka, K.1    Feustel, P.J.2    Mongin, A.A.3    Tranmer, B.I.4    Kimelberg, H.K.5
  • 19
    • 0003536299 scopus 로고    scopus 로고
    • Free radicals in biology and medicine
    • Oxford University Press, Oxford, New York1999
    • Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. Oxford University Press, Oxford, New York1999.
    • Halliwell, B.1    Gutteridge, J.M.C.2
  • 20
    • 0032007328 scopus 로고    scopus 로고
    • Modification of ion homeostasis by lipid peroxidation: Roles in neuronal degeneration and adaptive plasticity
    • Mattson MP. Modification of ion homeostasis by lipid peroxidation: Roles in neuronal degeneration and adaptive plasticity. Trends Neurosci 1998; 21: 53-57.
    • (1998) Trends Neurosci , vol.21 , pp. 53-57
    • Mattson, M.P.1
  • 21
    • 33947676341 scopus 로고    scopus 로고
    • Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity
    • Zhang Y, Milatovic D, Aschner M, Feustel PJ, Kimelberg HK. Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity. Exp Neurol 2007; 204: 819-827.
    • (2007) Exp Neurol , vol.204 , pp. 819-827
    • Zhang, Y.1    Milatovic, D.2    Aschner, M.3    Feustel, P.J.4    Kimelberg, H.K.5
  • 22
    • 0036838768 scopus 로고    scopus 로고
    • Protective effects of estrogen and selective estrogen receptor modulators in the brain
    • Dhandapani KM, Brann DW. Protective effects of estrogen and selective estrogen receptor modulators in the brain. Biol Reprod 2002; 67: 1379-1385.
    • (2002) Biol Reprod , vol.67 , pp. 1379-1385
    • Dhandapani, K.M.1    Brann, D.W.2
  • 23
    • 0037319445 scopus 로고    scopus 로고
    • Estrogen and stroke: A balanced analysis
    • Hurn PD, Brass LM. Estrogen and stroke: A balanced analysis. Stroke 2003; 34: 338-341.
    • (2003) Stroke , vol.34 , pp. 338-341
    • Hurn, P.D.1    Brass, L.M.2
  • 24
    • 0034237128 scopus 로고    scopus 로고
    • Neuroprotective effects of estrogens: Potential mechanisms of action
    • Green PS, Simpkins JW. Neuroprotective effects of estrogens: Potential mechanisms of action. Int J Dev Neurosci 2000; 18: 347-358.
    • (2000) Int J Dev Neurosci , vol.18 , pp. 347-358
    • Green, P.S.1    Simpkins, J.W.2
  • 25
    • 0034018107 scopus 로고    scopus 로고
    • Estradiol exerts neuroprotective effects when administered after ischemic insult
    • Yang SH, Shi J, Day AL, Simpkins JW. Estradiol exerts neuroprotective effects when administered after ischemic insult. Stroke 2000; 31: 745-749.
    • (2000) Stroke , vol.31 , pp. 745-749
    • Yang, S.H.1    Shi, J.2    Day, A.L.3    Simpkins, J.W.4
  • 26
    • 0027749134 scopus 로고
    • ICI 182,780: A pure antiestrogen that affects behaviors and energy balance in rats without acting in the brain
    • Wade GN, Blaustein JD, Gray JM, Meredith JM. ICI 182,780: A pure antiestrogen that affects behaviors and energy balance in rats without acting in the brain. Am J Physiol 1993; 265: R1392-R1398.
    • (1993) Am J Physiol , vol.265
    • Wade, G.N.1    Blaustein, J.D.2    Gray, J.M.3    Meredith, J.M.4
  • 27
    • 0027469702 scopus 로고
    • Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen
    • Couldwell WT, Weiss MH, DeGiorgio CM, et al. Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen. Neurosurg 1993; 32: 485-489.
    • (1993) Neurosurg , vol.32 , pp. 485-489
    • Couldwell, W.T.1    Weiss, M.H.2    DeGiorgio, C.M.3
  • 28
    • 0030808172 scopus 로고    scopus 로고
    • A phase I study of high-dose tamoxifen for the treatment of refractory malignant gliomas of childhood
    • Pollack IF, DaRosso RC, Robertson PL, et al. A phase I study of high-dose tamoxifen for the treatment of refractory malignant gliomas of childhood. Clin Cancer Res 1997; 3: 1109-1115
    • (1997) Clin Cancer Res , vol.3 , pp. 1109-1115
    • Pollack, I.F.1    DaRosso, R.C.2    Robertson, P.L.3
  • 29
    • 32144453826 scopus 로고    scopus 로고
    • NXY-059 for acute ischemic stroke
    • Lees KR, Zivin JA, Ashwood T, et al. NXY-059 for acute ischemic stroke. N Engl J Med 2006; 354: 588-600.
    • (2006) N Engl J Med , vol.354 , pp. 588-600
    • Lees, K.R.1    Zivin, J.A.2    Ashwood, T.3
  • 30
    • 0028171661 scopus 로고
    • Inhibition of volume-activated I and taurine efflux from HeLa cells by P-glycoprotein blockers correlates with calmodulin inhibition
    • Kirk J, Kirk K. Inhibition of volume-activated I and taurine efflux from HeLa cells by P-glycoprotein blockers correlates with calmodulin inhibition. J Biol Chem 1994: 269: 29389-29394.
    • (1994) J Biol Chem , vol.269 , pp. 29389-29394
    • Kirk, J.1    Kirk, K.2
  • 31
    • 34247263212 scopus 로고    scopus 로고
    • A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: A need for more rigorous testing of neuroprotective agents in animal models of stroke
    • Savitz SI. A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: A need for more rigorous testing of neuroprotective agents in animal models of stroke. Exp Neurol 2007; 205: 20-25.
    • (2007) Exp Neurol , vol.205 , pp. 20-25
    • Savitz, S.I.1
  • 32
    • 32844469368 scopus 로고    scopus 로고
    • Brain penetration of the novel free radical trapping neuroprotectant NXY-059 in rats subjected to permanent focal ischemia
    • Green AR, Lanbedk-Vallen K, Ashwood T, et al. Brain penetration of the novel free radical trapping neuroprotectant NXY-059 in rats subjected to permanent focal ischemia. Brain Res 2006; 1072: 224-226.
    • (2006) Brain Res , vol.1072 , pp. 224-226
    • Green, A.R.1    Lanbedk-Vallen, K.2    Ashwood, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.