Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice

Journal of Immunology

Volumn 180, Issue 5, 2008, Pages 3250-3259

  Serreze, David V ^a   Choisy Rossi, Caroline Morgane ^a   Grier, Alexandra E ^a   Holl, T Mathew ^a   Chapman, Harold D ^a   Gahagan, J Reed ^a   Osborne, Melissa A ^a   Zhang, Weidong ^a   King, Benjamin L ^a   Brown, Aaron ^b   Roopenian, Derry ^a   Marron, Michele P ^c  

^a JACKSON LABORATORY   (United States)

^b Bar Harbor Biotechology Incorporated   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CD8+ T LYMPHOCYTE; CHROMOSOME 7; CONGENIC STRAIN; DIABETOGENESIS; GENE DELETION; GENETIC POLYMORPHISM; IDD7 GENE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; THYMOCYTE; THYMUS; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CLONE; CELL DIFFERENTIATION; CHROMOSOME MAP; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; PATHOLOGY; QUANTITATIVE TRAIT LOCUS; TRANSGENIC MOUSE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CHROMOSOME MAPPING; CLONAL DELETION; CLONE CELLS; DIABETES MELLITUS, TYPE 1; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, TRANSGENIC; QUANTITATIVE TRAIT LOCI; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; THYMUS GLAND;

EID: 49149106972     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.5.3250     Document Type: Article

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