Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7-36) amide

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 16, 2008, Pages 7607-7614

  Chi, Yushi ^a   Zhang, Huibin ^a   Huang, Wenlong ^a   Zhou, Jinpei ^a   Zhou, Yinghong ^a   Qian, Hai ^a   Ni, Shuaijian ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

DPP IV; GLP 1; Glucose lowering effect; Microwave; PEGylation

Indexed keywords

ALANINE; CYSTEINE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCOSE; GLYCINE; THIOL GROUP;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DEGRADATION; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; HYDROLYSIS; MALE; MASS SPECTROMETRY; MICROWAVE IRRADIATION; MOUSE; NONHUMAN; SOLID PHASE SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD26; BLOOD GLUCOSE; GLUCAGON-LIKE PEPTIDE 1; HYPOGLYCEMIC AGENTS; MALE; MICE; MICROWAVES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POLYETHYLENE GLYCOLS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 49149093706     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.019     Document Type: Article

References (33)

1. Abraham E.J., Leech C.A., and Lin J.C. Endocrinology 143 (2002) 3152
2. Orskov C. Diabetologia 35 (1992) 701
3. Hui H.X., Zhao X.N., and Perfetti Riccardo. Diabetes Metab. Res. Rev. 21 (2005) 313
4. Nauck M.A., Heimesaat M.M., Orskov C., Holst J.J., Ebert R., and Creutzfeldt W. J. Clin. Invest. 91 (1993) 301
5. Qualmann C., Nauck M.A., Holst J.J., Orskov C., and Creutzfeldt W. Acta Diabetol. 32 (1995) 13
6. Hvidberg A., Nielsen M.T., Hilsted J., Orskov C., and Holst J.J. Metabolism 43 (1994) 104
7. Turton M.D., O'Shea D., and Gunn I. Nature 379 (1996) 69
8. Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., and Butler P.C. Diabetes 52 (2003) 102
9. Dardevet D., Moore M.C., Neal D., DiCostanze C.A., Snead W., and Cherrington A.D. Am. J. Physiol. Endocrinol. Metab. 287 (2004) 75
10. Nauck M.A., and Meier J.J. Regul. Pept. 128 (2005) 135
11. Mentlein R., Gallwitz B., and Schmidt W.E.Eur. J. Biochem. 214 (1993) 829
12. Deacon C.F., Nauck M.A., Toft-Nielsen M., Pridal L., Willms B., and Holst J.J. Diabetes 44 (1995) 1126
13. Pauly R.P., Rosche F., Wermann M., Mclntosh C.H.S., Pederson R.A., and Demuth H.-U. J. Biol. Chem. 271 (1996) 23222
14. Knudsen L.B., and Pridal L. Eur. J. Pharmacol. 318 (1996) 429
15. Hupe-Sodmann K., McGregor G.P., Bridenbaugh R., Goke R., Goke B., Thole H., and Zimmermann B. Regul. Pept. 58 (1995) 149
16. Green B.D., Mooney M.H., Gault V.A., Irwin N., Bailey C.J., Harriitt P., Greer B., Flatt P.R., and O'Harte F.P.M. Metabolism 53 (2004) 252
17. O'Harte F.P.M., Mooney M.H., Lawlor A., and Flatt P.R. Biochim. Biophys. Acta 1474 (2000) 13
18. Gallwitz B., Ropeter T., Morys-Wortmann C., Mentlein R., Siegel E.G., and Schmidt W.E. Regul. Pept. 86 (2000) 103
19. Yu P., Zheng C., Chen J., Zhang G., Liu Y., Suo X., Zhang G., and Su Z. Bioorg. Med. Chem. 15 (2007) 5396
20. Zalipsky S. Adv. Drug Delivery Rev. 16 (1995) 157
21. Lee S.H., Lee S., Youn Y.S., Na D.H., Chae S.Y., Byun Y., and Lee K.C. Bioconjugate Chem. 16 (2005) 377
22. Youn Y.S., Chae S.Y., Lee S., Jeon J.E., Shin H.G., and Lee K.C. Biochem. Pharmacol. 73 (2007) 84
23. Adelhorst K., Hedegaard B.B., Knudsen L.B., and Kirk O. J. Biol. Chem. 269 (1994) 6275
24. Deacon C.F., Knudsen L.B., Madsen K., Wiberg F.C., Jacobsen O., and Holst J.J. Diabetologia 41 (1998) 271
25. Burcelin R., Dolci W., and Thorens B. Metabolism 48 (1999) 252
26. Farha O.K., Julius R.L., and Hawthorne M.F. Tetrahedron Lett. 47 (2006) 2619
27. Merrifield R.B. Angew. Chem., Int. Ed. Engl. 24 (1985) 799
28. Abdel Rahman S., EI-Kafrawy A., Hattaba A., and Anwer M.F. Amino Acids 33 (2007) 531
29. Kappe C.O. Angew. Chem. Int. Ed. 43 (2004) 6250
30. Matsushita T., Hinou H., Kurogochi M., Shimizu H., and Nishimura S.I. Org. Lett. 7 (2005) 877
31. Yu H.M., Chen S.T., and Wang K.T. J. Org. Chem. 57 (1992) 4781
32. Erdelyi M., and Gogoll A. Synthesis 11 (2002) 1592
33. Zhou H.Y., Xiu Z.Y., and Chen C.Q. Chin. J. Biochem. Pharm. 23 (2002) 109