Investigation on PEGylation strategy of recombinant human interleukin-1 receptor antagonist

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 16, 2007, Pages 5396-5405

  Yu, Pengzhan ^a,b   Zheng, Chunyang ^a,b   Chen, Jing ^a,b   Zhang, Guifeng ^a   Liu, Yongdong ^a   Suo, Xiaoyan ^a,b   Zhang, Guicai ^c   Su, Zhiguo ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c Beijing Baiao Pharmaceuticals Co Ltd   (China)

Author keywords

Binding activities to the receptors; Interleukin 1 receptor antagonist; PEGylation

Indexed keywords

CARBOXYMETHYLPOLYETHYLENE GLYCOL SUCCINIMIDYL ESTER; MACROGOL DERIVATIVE; MALEIMIDE POLYETHYLENE GLYCOL; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT PLUS CARBOXYMETHYLPOLYETHYLENE GLYCOL SUCCINIMIDYL ESTER; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT PLUS MALEIMIDE POLYETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING SITE; DRUG CONJUGATION; DRUG DESIGN; DRUG PEGYLATION; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GEL PERMEATION CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CELL LINE; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; ESTERS; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; MALEIMIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYETHYLENE GLYCOLS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 34250752396     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.061     Document Type: Article

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