Selective inhibition of human heteromeric α9α10 nicotinic acetylcholine receptors at a low agonist concentration by low concentrations of ototoxic organic solvents

Toxicology in Vitro

Volumn 22, Issue 6, 2008, Pages 1568-1572

  van Kleef, Regina G D M ^a   Vijverberg, Henk P M ^a   Westerink, Remco H S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Ethylbenzene; Ototoxicity; Two electrode voltage clamp; Xenopus oocyte; Xylene

Indexed keywords

ALPHA9ALPHA10 NICOTINIC ACETYLCHOLINE RECEPTOR; ETHYLBENZENE; META XYLENE; NICOTINIC RECEPTOR; ORGANIC SOLVENT; ORTHO XYLENE; PARA XYLENE;

ARTICLE; CONCENTRATION (PARAMETERS); ELECTROPHYSIOLOGY; HEARING LOSS; ION CURRENT; NONHUMAN; OOCYTE; OTOTOXICITY; XENOPUS;

ACETYLCHOLINE; ANIMALS; BENZENE DERIVATIVES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEARING DISORDERS; HUMANS; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, NICOTINIC; SOLVENTS; XENOPUS LAEVIS; XYLENES;

EID: 49149086247     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.06.007     Document Type: Article

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