Preparation, characterization of paclitaxel-loaded Pluronic P105 polymeric micelles and in vitro reversal of multidrug resistant tumor

Yaoxue Xuebao

Volumn 43, Issue 6, 2008, Pages 640-646

  Wang, Yong Zhong ^a,b   Fang, Xiao Ling ^a   Li, Ya Juan ^a   Zhang, Zhi Wen ^a   Han, Li Mei ^a   Sha, Xian Yi ^a  

^a FUDAN UNIVERSITY   (China)

^b ANHUI UNIVERSITY   (China)

Author keywords

Central composite design; Multidrug resistance; Paclitaxel; Pluronic; Polymeric micelle

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG CARRIER; EXCIPIENT; PACLITAXEL; PLURONIC P105; POLOXAMER;

ARTICLE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG RESISTANCE; FEMALE; HUMAN; IC 50; METABOLISM; MICELLE; MULTIDRUG RESISTANCE; OVARY TUMOR; PARTICLE SIZE; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; EXCIPIENTS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MICELLES; OVARIAN NEOPLASMS; PACLITAXEL; PARTICLE SIZE; POLOXAMER;

EID: 49049086510     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Jones M, Leroux J. Polymeric micelles - a new generation of colloidal drug carriers [J]. Eur J Pharm Biopharm, 1999,48:101-111.
2. Matsumura Y, Hamaguchi T, Ura T, et al. Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin [J]. Br J Cancer, 2004,91:1775-1781.
3. Kim TY, Kim DW, Chung JY, et al. Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies [J]. Clin Cancer Res, 2004,10: 3708-3716.
4. Danson S, Ferry D, Alakhov V, et al. Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP 1049C) in patients with advanced cancer [J]. Br J Cancer, 2004,90:2085-2091.
5. Wang YZ, Fang XL. Polymeric micelles and targeting drug delivery systems for cancer therapy [J]. Chin J New Drugs, 2005,14:1127-1131.
6. Huo M , Zhou J, Wei Y, et al. Preparation of paclitaxel-loaded chitosan polymeric micelles and influence of surface charges on their tissue biodistribution in mice [J]. Acta Pharm Sin, 2006,41:867-872.
7. Kabanov AV, Batrakova EV, Alakhov VY. Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery [J]. J Control Release, 2002,82: 189-212.
8. Alakhov V, Klinski E, Li SM, et al. Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials [J]. Colloids Surf B Biointerfaces, 1999, 16:113-134.
9. Kabanov AV, Batrakova EV, Alakhov VY. Pluronic block copolymers for overcoming drug resistance in cancer [J]. Adv Drug Deliv Rev, 2002,54:759-779.
10. Gao ZG, Fain HD, Rapoport N. Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound [J]. J Control Release, 2005,102:203-222.
11. Zhang XC, Jackson JK, Burt HM. Development of amphiphilic diblock copolymers as micellar carriers of taxol [J]. Int J Pharm, 1996,132:195-206.
12. Han LM. Study on polymeric micelle drug delivery systems for reversing multidrug resistance in cancer [D]. Shanghai: Fudan University, 2006.
13. Wang Y, Yu L, Han L, et al. Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines [J]. Int J Pharm, 2007,337:63-73.
14. Wu W, Cui GH, Lu B. Optimization of multiple variables: application of central composite design and overall desirability [J]. Chin Pharm J, 2000,35:530-533.
15. Gabrielsson J, Lindberg NO, Lundstedt T. Multivariate methods in pharmaceutical applications [J]. J Chemometrics, 2002,16:141-160.
16. Han LM, Guo J, Zhang LJ, et al. Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with Pluronic P123 [J]. Acta Pharmacol Sin, 2006,27: 747-753.
17. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays [J]. J Immunol Methods, 1983,65:55-63.
18. Batrakova EV, Han HY, Miller DW, et al. Effects of pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells [J]. Pharm Res, 1998,15:1525-1532.
19. Nsereko S, Amiji M. Localized delivery of paclitaxel in solid tumors from biodegradable chitin microparticle formulations [J]. Biomaterials, 2002,23:2723-2731.
20. Cho YW, Lee J, Lee SC, et al. Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles [J]. J Control Release, 2004,97:249-257.
21. Rapoport N, Pitt WG, Sun H, et al. Drug delivery in polymeric micelles: from in vitro to in vivo [J]. J Control Release, 2003,91:85-95.
22. van Zuylen L, Verweij J, Sparreboom A. Role of formulation vehicles in taxane pharmacology [J]. Invest New Drugs, 2001,19:125-141.
23. Webster LK, Woodcock DM, Rischin D, et al. Review: Cremophor: Pharmacological activity of an "inert" solubiliser [J]. J Oncol Pharm Pract, 1997,3:186-192.
24. Woodcock DM, Jefferson S, Linsenmeyer ME, et al. Reversal of the multidrug resistance phenotype with Cremophor EL, a common vehicle for water-insoluble vitamins and drugs [J]. Cancer Res, 1990,50:4199-4203.