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Volumn 14, Issue 3, 2008, Pages 373-380

Role of insulin signaling in maintaining energy homeostasis

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN DETEMIR; INSULIN GLARGINE; ISOPHANE INSULIN; DRUG DERIVATIVE;

EID: 48949090967     PISSN: 1530891X     EISSN: None     Source Type: Journal    
DOI: 10.4158/EP.14.3.373     Document Type: Review
Times cited : (29)

References (55)
  • 2
    • 33745838578 scopus 로고    scopus 로고
    • Central insulin action in energy and glucose homeostasis
    • Plum L, Belgardt BF, Brüning JC. Central insulin action in energy and glucose homeostasis. J Clin Invest. 2006; 116:1761-1766.
    • (2006) J Clin Invest , vol.116 , pp. 1761-1766
    • Plum, L.1    Belgardt, B.F.2    Brüning, J.C.3
  • 3
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;414: 799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 4
    • 0344305782 scopus 로고    scopus 로고
    • Insulin signaling in health and disease
    • White MF. Insulin signaling in health and disease. Science. 2003;302:1710-1711.
    • (2003) Science , vol.302 , pp. 1710-1711
    • White, M.F.1
  • 5
    • 0035044213 scopus 로고    scopus 로고
    • Clinical review 125: The insulin receptor and its cellular targets
    • Kido Y, Nakae J, Accili D. Clinical review 125: the insulin receptor and its cellular targets. J Clin Endocrinol Metab. 2001;86:972-979.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 972-979
    • Kido, Y.1    Nakae, J.2    Accili, D.3
  • 6
    • 0009579369 scopus 로고
    • Insulin exerts metabolic and growth-promoting effects by a direct action on the liver in vivo: Clarification of the functional significance of the portal vascular link between the beta cells of the pancreatic islets and the liver
    • Griffen SC, Russell SM, Katz LS, Nicoll CS. Insulin exerts metabolic and growth-promoting effects by a direct action on the liver in vivo: clarification of the functional significance of the portal vascular link between the beta cells of the pancreatic islets and the liver. Proc Natl Acad Sci U S A. 1987;84:7300-7304.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 7300-7304
    • Griffen, S.C.1    Russell, S.M.2    Katz, L.S.3    Nicoll, C.S.4
  • 7
    • 33845515150 scopus 로고    scopus 로고
    • The inhibitory effects of insulin on hepatic glucose production are both direct and indirect
    • Girard J. The inhibitory effects of insulin on hepatic glucose production are both direct and indirect. Diabetes. 2006;55(Suppl 2):S65-S69.
    • (2006) Diabetes , vol.55 , Issue.SUPPL. 2
    • Girard, J.1
  • 8
    • 0036177867 scopus 로고    scopus 로고
    • Control of energy homeostasis and insulin action by adipocyte hormones: Leptin, acylation stimulating protein, and adiponectin
    • Havel PJ. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol. 2002;13:51-59.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 51-59
    • Havel, P.J.1
  • 9
    • 0037303635 scopus 로고    scopus 로고
    • Gerozissis K. Brain insulin: regulation, mechanisms of action and functions [published correction appears in Cell Mol Neurobiol. 2003;23:873-874]. Cell Mol Neurobiol. 2003;23:1-25.
    • Gerozissis K. Brain insulin: regulation, mechanisms of action and functions [published correction appears in Cell Mol Neurobiol. 2003;23:873-874]. Cell Mol Neurobiol. 2003;23:1-25.
  • 10
    • 1842840805 scopus 로고    scopus 로고
    • Brain insulin and feeding: A bi-directional communication
    • Gerozissis K. Brain insulin and feeding: a bi-directional communication. Eur J Pharmacol. 2004;490:59-70.
    • (2004) Eur J Pharmacol , vol.490 , pp. 59-70
    • Gerozissis, K.1
  • 12
    • 33745106645 scopus 로고    scopus 로고
    • Drug insight: The role of leptin in human physiology and pathophysiology-emerging clinical applications
    • Brennan AM, Mantzoros CS. Drug insight: the role of leptin in human physiology and pathophysiology-emerging clinical applications. Nat Clin Pract Endocrinol Metab. 2006;2:318-327.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 318-327
    • Brennan, A.M.1    Mantzoros, C.S.2
  • 13
    • 17844379717 scopus 로고    scopus 로고
    • Hypothalamic K(ATP) channels control hepatic glucose production
    • Pocai A, Lam TK, Gutierrez-Juarez R, et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature. 2005;434:1026-1031.
    • (2005) Nature , vol.434 , pp. 1026-1031
    • Pocai, A.1    Lam, T.K.2    Gutierrez-Juarez, R.3
  • 14
    • 0036791462 scopus 로고    scopus 로고
    • Leptin and insulin action in the central nervous system
    • Porte D Jr, Baskin DG, Schwartz MW. Leptin and insulin action in the central nervous system. Nutr Rev. 2002;60(10 part 2):S20-S29.
    • (2002) Nutr Rev , vol.60 , Issue.10 PART 2
    • Porte Jr, D.1    Baskin, D.G.2    Schwartz, M.W.3
  • 15
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • Schwartz MW, Porte D Jr. Diabetes, obesity, and the brain. Science. 2005;307:375-379.
    • (2005) Science , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte Jr., D.2
  • 17
    • 0025359018 scopus 로고
    • Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat
    • McGowan MK, Andrews KM, Kelly J, Grossman SP. Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat. Behav Neurosci. 1990;104:373-385.
    • (1990) Behav Neurosci , vol.104 , pp. 373-385
    • McGowan, M.K.1    Andrews, K.M.2    Kelly, J.3    Grossman, S.P.4
  • 19
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Brüning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science. 2000;289:2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Brüning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 20
    • 0029758229 scopus 로고    scopus 로고
    • Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis
    • Tomaszuk A, Simpson C, Williams G. Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis. Horm Res. 1996;46:53-58.
    • (1996) Horm Res , vol.46 , pp. 53-58
    • Tomaszuk, A.1    Simpson, C.2    Williams, G.3
  • 21
    • 0035851851 scopus 로고    scopus 로고
    • The hypothalamus and the control of energy homeostasis: Different circuits, different purposes
    • Williams G, Bing C, Cai XJ, Harrold JA, King PJ, Liu XH. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav. 2001;74:683-701.
    • (2001) Physiol Behav , vol.74 , pp. 683-701
    • Williams, G.1    Bing, C.2    Cai, X.J.3    Harrold, J.A.4    King, P.J.5    Liu, X.H.6
  • 22
    • 0029035260 scopus 로고
    • Neuropeptide Y, the hypothalamus, and diabetes: Insights into the central control of metabolism
    • Frankish HM, Dryden S, Hopkins D, Wang Q, Williams G. Neuropeptide Y, the hypothalamus, and diabetes: insights into the central control of metabolism. Peptides. 1995;16:757-771.
    • (1995) Peptides , vol.16 , pp. 757-771
    • Frankish, H.M.1    Dryden, S.2    Hopkins, D.3    Wang, Q.4    Williams, G.5
  • 23
    • 0035883810 scopus 로고    scopus 로고
    • Role of melanocortins in control of obesity
    • Wisse BE, Schwartz MW. Role of melanocortins in control of obesity. Lancet. 2001;358:857-859.
    • (2001) Lancet , vol.358 , pp. 857-859
    • Wisse, B.E.1    Schwartz, M.W.2
  • 24
    • 0034942447 scopus 로고    scopus 로고
    • Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications
    • Porte D Jr. Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications. Diabetes Metab Res Rev. 2001;17:181-188.
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 181-188
    • Porte Jr., D.1
  • 25
    • 12344266697 scopus 로고    scopus 로고
    • How obesity causes diabetes: Not a tall tale
    • Lazar MA. How obesity causes diabetes: not a tall tale. Science. 2005;307:373-375.
    • (2005) Science , vol.307 , pp. 373-375
    • Lazar, M.A.1
  • 26
    • 0023791423 scopus 로고
    • Weight gain associated with intensive therapy in the Diabetes Control and Complications Trial
    • DCCT Research Group
    • DCCT Research Group. Weight gain associated with intensive therapy in the Diabetes Control and Complications Trial. Diabetes Care. 1988;11:567-573.
    • (1988) Diabetes Care , vol.11 , pp. 567-573
  • 27
    • 0032511583 scopus 로고    scopus 로고
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) [published correction appears in Lancet. 1999;354:602]. Lancet. 1998;352:837-853.
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) [published correction appears in Lancet. 1999;354:602]. Lancet. 1998;352:837-853.
  • 30
    • 30744454261 scopus 로고    scopus 로고
    • Glucose control-related" and "non-glucose control-related" effects of insulin on weight gain in newly insulin-treated type 2 diabetic patients
    • Sallé A, Ryan M, Guilloteau G, Bouhanick B, Berrut G, Ritz P. "Glucose control-related" and "non-glucose control-related" effects of insulin on weight gain in newly insulin-treated type 2 diabetic patients. Br J Nutr. 2005;94: 931-937.
    • (2005) Br J Nutr , vol.94 , pp. 931-937
    • Sallé, A.1    Ryan, M.2    Guilloteau, G.3    Bouhanick, B.4    Berrut, G.5    Ritz, P.6
  • 31
    • 77649091668 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus
    • AACE Diabetes Mellitus Clinical Practice Guidelines Task Force
    • AACE Diabetes Mellitus Clinical Practice Guidelines Task Force. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract. 2007;13(Suppl 1):1-68.
    • (2007) Endocr Pract , vol.13 , Issue.SUPPL. 1 , pp. 1-68
  • 32
    • 33845965337 scopus 로고    scopus 로고
    • Intermediate and long-acting insulins: A review of NPH insulin, insulin glargine and insulin detemir
    • Peterson GE. Intermediate and long-acting insulins: a review of NPH insulin, insulin glargine and insulin detemir. Curr Med Res Opin. 2006;22:2613-2619.
    • (2006) Curr Med Res Opin , vol.22 , pp. 2613-2619
    • Peterson, G.E.1
  • 33
    • 12744274870 scopus 로고    scopus 로고
    • Lower within-subject variability of fasting blood glucose and reduced weight gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes
    • Haak T, Tiengo A, Draeger E, Suntum M, Waldhäusl W. Lower within-subject variability of fasting blood glucose and reduced weight gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes. Diabetes Obes Metab. 2005;7:56-64.
    • (2005) Diabetes Obes Metab , vol.7 , pp. 56-64
    • Haak, T.1    Tiengo, A.2    Draeger, E.3    Suntum, M.4    Waldhäusl, W.5
  • 34
    • 2442678007 scopus 로고    scopus 로고
    • Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with type 1 diabetes
    • Hermansen K, Fontaine P, Kukolja KK, Peterkova V, Leth G, Gall MA. Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with type 1 diabetes. Diabetologia. 2004;47: 622-629.
    • (2004) Diabetologia , vol.47 , pp. 622-629
    • Hermansen, K.1    Fontaine, P.2    Kukolja, K.K.3    Peterkova, V.4    Leth, G.5    Gall, M.A.6
  • 35
    • 2342621441 scopus 로고    scopus 로고
    • (Study to Evaluate the Administration of Detemir Insulin Efficacy, Safety and Suitability [STEADINESS] Study Group). Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes: A randomized clinical trial
    • Home P, Bartley P, Russell-Jones D, et al (Study to Evaluate the Administration of Detemir Insulin Efficacy, Safety and Suitability [STEADINESS] Study Group). Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes: a randomized clinical trial. Diabetes Care. 2004;27:1081-1087.
    • (2004) Diabetes Care , vol.27 , pp. 1081-1087
    • Home, P.1    Bartley, P.2    Russell-Jones, D.3
  • 36
    • 21744451635 scopus 로고    scopus 로고
    • Comparison of three multiple injection regimens for type 1 diabetes: Morning plus dinner or bedtime administration of insulin detemir vs. morning plus bedtime NPH insulin
    • Pieber TR, Draeger E, Kristensen A, Grill V. Comparison of three multiple injection regimens for type 1 diabetes: morning plus dinner or bedtime administration of insulin detemir vs. morning plus bedtime NPH insulin. Diabet Med. 2005;22:850-857.
    • (2005) Diabet Med , vol.22 , pp. 850-857
    • Pieber, T.R.1    Draeger, E.2    Kristensen, A.3    Grill, V.4
  • 37
    • 6944244979 scopus 로고    scopus 로고
    • Raslová K, Bogoev M, Raz I, Leth G, Gall MA, Hâncu N. Insulin detemir and insulin aspart: a promising basalbolus regimen for type 2 diabetes [published correction appears in Diabetes Res Clin Pract. 2006;72:112]. Diabetes Res Clin Pract. 2004;66:193-201.
    • Raslová K, Bogoev M, Raz I, Leth G, Gall MA, Hâncu N. Insulin detemir and insulin aspart: a promising basalbolus regimen for type 2 diabetes [published correction appears in Diabetes Res Clin Pract. 2006;72:112]. Diabetes Res Clin Pract. 2004;66:193-201.
  • 38
    • 2942574527 scopus 로고    scopus 로고
    • Effects of QD insulin detemir or neutral protamine Hagedorn on blood glucose control in patients with type I diabetes mellitus using a basal-bolus regimen
    • Russell-Jones D, Simpson R, Hylleberg B, Draeger E, Bolinder J. Effects of QD insulin detemir or neutral protamine Hagedorn on blood glucose control in patients with type I diabetes mellitus using a basal-bolus regimen. Clin Ther. 2004;26:724-736.
    • (2004) Clin Ther , vol.26 , pp. 724-736
    • Russell-Jones, D.1    Simpson, R.2    Hylleberg, B.3    Draeger, E.4    Bolinder, J.5
  • 39
    • 33746391488 scopus 로고    scopus 로고
    • Hermansen K, Davies M, Derezinski T, Ravn GM, Clauson P, Home P. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes [published correction appears in Diabetes Care. 2007;30:1035]. Diabetes Care. 2006;29:1269-1274.
    • Hermansen K, Davies M, Derezinski T, Ravn GM, Clauson P, Home P. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes [published correction appears in Diabetes Care. 2007;30:1035]. Diabetes Care. 2006;29:1269-1274.
  • 40
    • 33845236398 scopus 로고    scopus 로고
    • Philis-Tsimikas A, Charpentier G, Clauson P, Ravn GM, Roberts VL, Thorsteinsson B. Comparison of oncedaily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly controlled type 2 diabetes [published correction appears in Clin Ther. 2006;28:1967]. Clin Ther. 2006;28:1569-1581.
    • Philis-Tsimikas A, Charpentier G, Clauson P, Ravn GM, Roberts VL, Thorsteinsson B. Comparison of oncedaily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly controlled type 2 diabetes [published correction appears in Clin Ther. 2006;28:1967]. Clin Ther. 2006;28:1569-1581.
  • 41
    • 33845980344 scopus 로고    scopus 로고
    • Insulin detemir added to oral antidiabetic drugs in type 2 diabetes provides glycemic control comparable to insulin glargine with less weight gain [abstract]
    • Rosenstock J, Davies M, Home PD, Larsen J, Tamer SC, Schernthanr G. Insulin detemir added to oral antidiabetic drugs in type 2 diabetes provides glycemic control comparable to insulin glargine with less weight gain [abstract]. Diabetes. 2006;55(Suppl 1):A132.
    • (2006) Diabetes , vol.55 , Issue.SUPPL. 1
    • Rosenstock, J.1    Davies, M.2    Home, P.D.3    Larsen, J.4    Tamer, S.C.5    Schernthanr, G.6
  • 42
    • 85036781859 scopus 로고    scopus 로고
    • Treatment with insulin detemir provides improved glycaemic control and less weight gain compared to NPH insulin in people with diabetes [abstract 150]
    • Garber AJ, Kim H, Draeger E. Treatment with insulin detemir provides improved glycaemic control and less weight gain compared to NPH insulin in people with diabetes [abstract 150]. Diabetologia. 2004;47(Suppl 1):A58.
    • (2004) Diabetologia , vol.47 , Issue.SUPPL. 1
    • Garber, A.J.1    Kim, H.2    Draeger, E.3
  • 43
    • 24744442762 scopus 로고    scopus 로고
    • Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy
    • Fulcher GR, Gilbert RE, Yue DK. Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy. Intern Med J. 2005;35:536-542.
    • (2005) Intern Med J , vol.35 , pp. 536-542
    • Fulcher, G.R.1    Gilbert, R.E.2    Yue, D.K.3
  • 44
    • 0033766190 scopus 로고    scopus 로고
    • A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes
    • Raskin P, Klaff L, Bergenstal R, Hallé JP, Donley D, Mecca T. A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes. Diabetes Care. 2000;23:1666-1671.
    • (2000) Diabetes Care , vol.23 , pp. 1666-1671
    • Raskin, P.1    Klaff, L.2    Bergenstal, R.3    Hallé, J.P.4    Donley, D.5    Mecca, T.6
  • 45
    • 0038131919 scopus 로고    scopus 로고
    • Glimepiride combined with morning insulin glargine, bedtime neutral protamine Hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes: A randomized, controlled trial
    • 4001 Study Group
    • Fritsche A, Schweitzer MA, Häring HU (4001 Study Group). Glimepiride combined with morning insulin glargine, bedtime neutral protamine Hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes: a randomized, controlled trial. Ann Intern Med. 2003;138: 952-959.
    • (2003) Ann Intern Med , vol.138 , pp. 952-959
    • Fritsche, A.1    Schweitzer, M.A.2    Häring, H.U.3
  • 46
    • 0038292180 scopus 로고    scopus 로고
    • A one-year, randomised, multicentre trial comparing insulin glargine with NPH insulin in combination with oral agents in patients with type 2 diabetes
    • Massi Benedetti M, Humburg E, Dressler A, Ziemen M. A one-year, randomised, multicentre trial comparing insulin glargine with NPH insulin in combination with oral agents in patients with type 2 diabetes. Horm Metab Res. 2003;35:189-196.
    • (2003) Horm Metab Res , vol.35 , pp. 189-196
    • Massi Benedetti, M.1    Humburg, E.2    Dressler, A.3    Ziemen, M.4
  • 47
    • 0242269000 scopus 로고    scopus 로고
    • (Insulin Glargine 4002 Study Investigators). The treat-to-target trial: Randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    • Riddle MC, Rosenstock J, Gerich J (Insulin Glargine 4002 Study Investigators). The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care. 2003;26:3080-3086.
    • (2003) Diabetes Care , vol.26 , pp. 3080-3086
    • Riddle, M.C.1    Rosenstock, J.2    Gerich, J.3
  • 48
    • 33244479164 scopus 로고    scopus 로고
    • Insulin glargine or NPH combined with metformin in type 2 diabetes: The LANMET study
    • Yki-Järvinen H, Kauppinen-Mäkelin R, Tiikkainen M, et al. Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study. Diabetologia. 2006; 49:442-451.
    • (2006) Diabetologia , vol.49 , pp. 442-451
    • Yki-Järvinen, H.1    Kauppinen-Mäkelin, R.2    Tiikkainen, M.3
  • 49
    • 33748555885 scopus 로고    scopus 로고
    • Insulin detemir lowers the risk of hypoglycaemia and provides more consistent plasma glucose levels compared with NPH insulin in type 1 diabetes
    • Kølendorf K, Ross GP, Pavlic-Renart I, et al. Insulin detemir lowers the risk of hypoglycaemia and provides more consistent plasma glucose levels compared with NPH insulin in type 1 diabetes. Diabet Med. 2006;23:729-735.
    • (2006) Diabet Med , vol.23 , pp. 729-735
    • Kølendorf, K.1    Ross, G.P.2    Pavlic-Renart, I.3
  • 50
    • 34249297061 scopus 로고    scopus 로고
    • Comparison of insulin detemir and insulin glargine in subjects with type 1 diabetes using intensive insulin therapy
    • Pieber TR, Treichel HC, Hompesch B, et al. Comparison of insulin detemir and insulin glargine in subjects with type 1 diabetes using intensive insulin therapy. Diabet Med. 2007;24:635-642.
    • (2007) Diabet Med , vol.24 , pp. 635-642
    • Pieber, T.R.1    Treichel, H.C.2    Hompesch, B.3
  • 51
    • 33947644686 scopus 로고    scopus 로고
    • No correlation between weight gain and number of hypoglycemic events in patients with type 2 diabetes treated with insulin detemir as compared to NPH insulin [abstract]
    • Davies M, Derezinski T, Kim H, Clauson P. No correlation between weight gain and number of hypoglycemic events in patients with type 2 diabetes treated with insulin detemir as compared to NPH insulin [abstract]. Diabetes. 2006;55(Suppl 1):A466.
    • (2006) Diabetes , vol.55 , Issue.SUPPL. 1
    • Davies, M.1    Derezinski, T.2    Kim, H.3    Clauson, P.4
  • 52
    • 4344701890 scopus 로고    scopus 로고
    • The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin
    • Havelund S, Plum A, Ribel U, et al. The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin. Pharm Res. 2004;21:1498-1504.
    • (2004) Pharm Res , vol.21 , pp. 1498-1504
    • Havelund, S.1    Plum, A.2    Ribel, U.3
  • 53
    • 16844368165 scopus 로고    scopus 로고
    • Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycaemic clamp
    • Hordern SV, Wright JE, Umpleby AM, Shojaee-Moradie F, Amiss J, Russell-Jones DL. Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycaemic clamp. Diabetologia. 2005;48:420-426.
    • (2005) Diabetologia , vol.48 , pp. 420-426
    • Hordern, S.V.1    Wright, J.E.2    Umpleby, A.M.3    Shojaee-Moradie, F.4    Amiss, J.5    Russell-Jones, D.L.6
  • 54
    • 33646530498 scopus 로고    scopus 로고
    • Tissue selectivity of insulin detemir action in vivo
    • Hennige AM, Sartorius T, Tschritter O, et al. Tissue selectivity of insulin detemir action in vivo. Diabetologia. 2006;49:1274-1282.
    • (2006) Diabetologia , vol.49 , pp. 1274-1282
    • Hennige, A.M.1    Sartorius, T.2    Tschritter, O.3
  • 55
    • 33947320828 scopus 로고    scopus 로고
    • Neuronal activation of the human cerebral cortex by administration of insulin detemir compared to human insulin [abstract]
    • Tschritter O, Porubska K, Hennige AM, et al. Neuronal activation of the human cerebral cortex by administration of insulin detemir compared to human insulin [abstract]. Diabetologia. 2005;48(Suppl 1):A256.
    • (2005) Diabetologia , vol.48 , Issue.SUPPL. 1
    • Tschritter, O.1    Porubska, K.2    Hennige, A.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.