Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice

FEBS Letters

Volumn 582, Issue 19, 2008, Pages 2911-2915

  Dahlhoff, Maik ^a   Horst, David ^a   Gerhard, Markus ^b   Kolligs, Frank T ^a   Wolf, Eckhard ^a   Schneider, Marlon R ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apc+ Min; Betacellulin; Epidermal growth factor receptor; Intestine; Transgenic mice

Indexed keywords

BETACELLULIN; CASPASE 3; EPIDERMAL GROWTH FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HISTOPATHOLOGY; HYPERPLASIA; INTESTINE CRYPT; INTESTINE EPITHELIUM; INTESTINE POLYP; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; CELL PROLIFERATION; HYPERPLASIA; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; MICE; MICE, TRANSGENIC; ORGAN SIZE; RECEPTOR, EPIDERMAL GROWTH FACTOR;

MUS; MUS MUSCULUS;

EID: 48949089326     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.07.026     Document Type: Article

References (26)

1. Amit I., Wides R., and Yarden Y. Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy. Mol. Syst. Biol. 3 (2007) 151
2. Harris R.C., Chung E., and Coffey R.J. EGF receptor ligands. Exp. Cell Res. 284 (2003) 2-13
3. Barnard J.A., Beauchamp R.D., Russell W.E., Dubois R.N., and Coffey R.J. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology 108 (1995) 564-580
4. Threadgill D.W., Dlugosz A.A., Hansen L.A., Tennenbaum T., Lichti U., Yee D., LaMantia C., Mourton T., Herrup K., and Harris R.C. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269 (1995) 230-234
5. Miettinen P.J., Berger J.E., Meneses J., Phung Y., Pedersen R.A., Werb Z., and Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376 (1995) 337-341
6. Egger B., Procaccino F., Lakshmanan J., Reinshagen M., Hoffmann P., Patel A., Reuben W., Gnanakkan S., Liu L., Barajas L., and Eysselein V.E. Mice lacking transforming growth factor alpha have an increased susceptibility to dextran sulfate-induced colitis. Gastroenterology 113 (1997) 825-832
7. Lee D., Pearsall R.S., Das S., Dey S.K., Godfrey V.L., and Threadgill D.W. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol. Cell Biol. 24 (2004) 8907-8916
8. Troyer K.L., Luetteke N.C., Saxon M.L., Qiu T.H., Xian C.J., and Lee D.C. Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha. Gastroenterology 121 (2001) 68-78
9. Erwin C.R., Helmrath M.A., Shin C.E., Falcone Jr. R.A., Stern L.E., and Warner B.W. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am. J. Physiol. 277 (1999) G533-G540
10. Acra S.A., Bulus N., Bogatcheva G., Coffey R.J., and Barnard J.A. Increased intestinal epithelial proliferation in metallothioneine-transforming growth factor alpha transgenic mice. Regul. Pept. 74 (1998) 105-112
11. Egger B., Carey H.V., Procaccino F., Chai N.N., Sandgren E.P., Lakshmanan J., Buslon V.S., French S.W., Buchler M.W., and Eysselein V.E. Reduced susceptibility of mice overexpressing transforming growth factor alpha to dextran sodium sulphate induced colitis. Gut 43 (1998) 64-70
12. Messa C., Russo F., Caruso M.G., and Di Leo A. EGF, TGF-alpha, and EGF-R in human colorectal adenocarcinoma. Acta Oncol. 37 (1998) 285-289
13. Normanno N., De Luca A., Bianco C., Strizzi L., Mancino M., Maiello M.R., Carotenuto A., De Feo G., Caponigro F., and Salomon D.S. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 366 (2006) 2-16
14. Zandi R., Larsen A.B., Andersen P., Stockhausen M.T., and Poulsen H.S. Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell Signal. 19 (2007) 2013-2023
15. Roberts R.B., Min L., Washington M.K., Olsen S.J., Settle S.H., Coffey R.J., and Threadgill D.W. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc. Natl. Acad. Sci. USA 99 (2002) 1521-1526
16. Bashir O., FitzGerald A.J., Berlanga-Acosta J., Playford R.J., and Goodlad R.A. Effect of epidermal growth factor administration on intestinal cell proliferation, crypt fission and polyp formation in multiple intestinal neoplasia (Min) mice. Clin. Sci. (London) 105 (2003) 323-330
17. Kallincos N.C., Xian C.J., Dunbar A.J., Couper R.T., and Read L.C. Cloning of rat betacellulin and characterization of its expression in the gastrointestinal tract. Growth Factors 18 (2000) 203-213
18. Howarth G.S., Bastian S.E., Dunbar A.J., and Goddard C. Betacellulin promotes growth of the gastrointestinal organs and effects a diuresis in normal rats. Growth Factors 21 (2003) 79-86
19. Schneider M.R., Dahlhoff M., Herbach N., Renner-Mueller I., Dalke C., Puk O., Graw J., Wanke R., and Wolf E. Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome, and complex eye pathology. Endocrinology 146 (2005) 5237-5246
20. Lee D., Cross S.H., Strunk K.E., Morgan J.E., Bailey C.L., Jackson I.J., and Threadgill D.W. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm. Genome 15 (2004) 525-536
21. Moser A.R., Pitot H.C., and Dove W.F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247 (1990) 322-324
22. Moolenbeek C., and Ruitenberg E.J. The "Swiss roll": a simple technique for histological studies of the rodent intestine. Lab. Anim. 15 (1981) 57-59
23. Gregorieff A., Grosschedl R., and Clevers H. Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J. 23 (2004) 1825-1833
24. Riese D.J., Bermingham Y., van Raaij T.M., Buckley S., Plowman G.D., and Stern D.F. Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta. Oncogene 12 (1996) 345-353
25. Gould K.A., Dietrich W.F., Borenstein N., Lander E.S., and Dove W.F. Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics 144 (1996) 1769-1776
26. Saito T., Okada S., Ohshima K., Yamada E., Sato M., Uehara Y., Shimizu H., Pessin J.E., and Mori M. Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF. Endocrinology 145 (2004) 4232-4243