Synthesis and structure-activity relationships of potent 1-(2-substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 8, 2008, Pages 1110-1117

  Fukushima, Hiroshi ^a   Hiratate, Akira ^a   Takahashi, Masato ^a   Saito Hori, Masako ^a   Munetomo, Eiji ^a   Kitano, Kiyokazu ^a   Saito, Hidetaka ^a   Takaoka, Yuji ^a   Yamamoto, Koji ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Diabetes; Dipeptidyl peptidase IV; Fluoropyrrolidine; Inhibitor

Indexed keywords

2 CYANO 4 FLUOROPYRROLIDINE DERIVATIVE; 4 FLUORO 1 (3 METHYLVALYL)PYRROLIDINE 2 CARBONITRILE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1; GLYCINE DERIVATIVE; PYRROLIDINE DERIVATIVE; TERT BUTYLGLYCINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INDICATION; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; ENZYME INHIBITORS; MICE; PROLINE; STRUCTURE-ACTIVITY RELATIONSHIP; VALINE;

EID: 48849111170     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.1110     Document Type: Article

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