Pulmonary fibrosis in L-NAME-treated mice is dependent on an activated endothelin system

Canadian Journal of Physiology and Pharmacology

Volumn 86, Issue 8, 2008, Pages 541-545

  Kalk, Philipp ^a,b   Mach, Alexander ^a   Thone Reineke, Christa ^a   Godes, Michael ^a   Heiden, Susi ^a   Sharkovska, Yuliya ^a   Von Websky, Karoline ^a   Relle, Katharina ^a,b   Hocher, Berthold ^a  

^a DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Endothelin; Fibrosis; Lung; NO

Indexed keywords

3 [2 (3,4 DIMETHOXYPHENYL)ETHOXY] 2 (4,6 DIMETHOXY 2 PYRIMIDINYLOXY) 3,3 DIPHENYLPROPIONIC ACID; ENDOTHELIN; ENDOTHELIN RECEPTOR ANTAGONIST; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRONCHUS; CELL INFILTRATION; CONTROLLED STUDY; FIBROSING ALVEOLITIS; HEART WEIGHT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LUNG FIBROSIS; LUNG WEIGHT; MACROPHAGE; MALE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BODY WEIGHT; ENDOTHELINS; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; LUNG; MACROPHAGES; MICE; MICE, TRANSGENIC; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ORGAN SIZE; PARAFFIN EMBEDDING; PHENOTYPE; PROPIONIC ACIDS; PULMONARY FIBROSIS; PYRIMIDINES; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B;

EID: 48849107319     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y08-047     Document Type: Article

References (11)

1. Boulanger, C., and Luscher, T.F. 1990. Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J. Clin. Invest. 85: 587-590. doi:10.1172/JCI114477. PMID:2153712.
2. de Nucci, G., Thomas, R., D'Orleans-Juste, P., Antunes, E., Walder, C., Warner, T.D., and Vane, J.R. 1988. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc. Natl. Acad. Sci. U.S.A. 85: 9797-9800. doi:10.1073/pnas.85.24.9797. PMID:3059352.
3. Giannessi, D., Del Ry, S., and Vitale, R.L. 2001. The role of endothelins and their receptors in heart failure. Pharmacol. Res. 43: 111-126. doi:10.1006/phrs.2000.0758. PMID:11243712.
4. Haffner, D., Hocher, B., Muller, D., Simon, K., Konig, K., Richter, C.M., et al. 2005. Systemic cardiovascular disease in uremic rats induced by 1,25(OH)2D3. J. Hypertens. 23: 1067-1075. PMID:15834294.
5. Hocher, B., Thone-Reineke, C., Rohmeiss, P., Schmager, F., Slowinski, T., Burst, V., et al. 1997. Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J. Clin. Invest. 99: 1380-1389. doi:10.1172/JCI119297. PMID:9077548.
6. Hocher, B., George, I., Rebstock, J., Bauch, A., Schwarz, A., Neumayer, H.H., and Bauer, C. 1999. Endothelin system-dependent cardiac remodeling in renovascular hypertension. Hypertension, 33: 816-822. PMID:10082493.
7. Hocher, B., George, I., Diekmann, F., Zart, R., Rebstock, J., Schwarz, A., et al. 2000a. ETA receptor blockade induces fibrosis of the clipped kidney in two-kidney-one-clip renovascular hypertensive rats. J. Hypertens. 18: 1807-1814. doi:10.1097/00004872-200018120-00015. PMID:11132605.
8. Hocher, B., Schwarz, A., Fagan, K.A., Thone-Reineke, C., El Hag, K., Kusserow, H., et al. 2000b. Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice. Am. J. Respir. Cell Mol. Biol. 23: 19-26. PMID:10873149.
9. Hocher, B., Schwarz, A., Slowinski, T., Bachmann, S., Pfeilschifter, J., Neumayer, H.H., and Bauer, C. 2004. In-vivo interaction of nitric oxide and endothelin. J. Hypertens. 22: 111-119. doi:10.1097/00004872-200401000- 00020. PMID:15106802.
10. Quaschning, T., Voss, F., Relle, K., Kalk, P., Vignon-Zellweger, N., Pfab, T., et al. 2007. Lack of endothelial nitric oxide synthase promotes endothelin-induced hypertension: lessons from endothelin-1 transgenic/ endothelial nitric oxide synthase knockout mice. J. Am. Soc. Nephrol. 18: 730-740. doi:10.1681/ASN.2006050541. PMID:17287431.
11. Slowinski, T., Kalk, P., Christian, M., Schmager, F., Relle, K., Godes, M., et al. 2007. Cell-type specific interaction of endothelin and the nitric oxide system: pattern of prepro-ET-1 expression in kidneys of L-NAME treated prepro-ET-1 promoter-lacZ-transgenic mice. J. Physiol. 581: 1173-1181. doi:10.1113/jphysiol.2007.131201. PMID:17395629.