MglA and Igl proteins contribute to the modulation of Francisella tularensis live vaccine strain-containing phagosomes in murine macrophages

Infection and Immunity

Volumn 76, Issue 8, 2008, Pages 3502-3510

  Bönquist, Linda ^a   Lindgren, Helena ^a   Golovliov, Igor ^a   Guina, Tina ^b   Sjöstedt, Anders ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IG1 PROTEIN; LIVE VACCINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MG1A PROTEIN; PROTEIN; BACTERIAL PROTEIN; BACTERIAL VACCINE; LAMP1 PROTEIN, MOUSE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; VIRULENCE FACTOR;

ANIMAL CELL; ARTICLE; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL SURVIVAL; CELL DIVISION; CELL GROWTH; CYTOPLASM; FRANCISELLA TULARENSIS; MACROPHAGE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; VIRULENCE; ANIMAL; BACTERIAL COUNT; CELL LINE; CELL SURVIVAL; CHEMISTRY; GENE DELETION; GENETIC COMPLEMENTATION; GENETICS; IMMUNOLOGY; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL VACCINES; CELL LINE; CELL SURVIVAL; COLONY COUNT, MICROBIAL; FRANCISELLA TULARENSIS; GENE DELETION; GENETIC COMPLEMENTATION TEST; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MACROPHAGES; MICE; PHAGOSOMES; VACCINES, ATTENUATED; VIRULENCE; VIRULENCE FACTORS;

EID: 48849105040     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00226-08     Document Type: Article

References (32)

1. Abd, H., T. Johansson, I. Golovliov, G. Sandström, and M. Forsman. 2003. Survival and growth of Francisella tularensis in Acanthamoeba castellanii. Appl. Environ Microbiol. 69:600-606.
2. Anthony, L. S., P. J. Morrissey, and F. E. Nano. 1992. Growth inhibition of Francisella tularensis live vaccine strain by IFN-gamma-activated macrophages is mediated by reactive nitrogen intermediates derived from L-arginine metabolism. J. Immunol. 148:1829-1834.
3. Balagopal, A., A. S. MacFarlane, N. Mohapatra, S. Soni, J. S. Gunn, and L. S. Schlesinger. 2006. Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages. Infect. Immun. 74:5114-5125.
4. Brotcke, A., D. S. Weiss, C. C. Kim, P. Chain, S. Malfatti, E. Garcia, and D. M. Monack. 2006. Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis. Infect. Immun. 74:6642-6655.
5. Brumell, J. H., and S. Grinstein. 2004. Salmonella redirects phagosomal maturation. Curr. Opin. Microbiol. 7:78-84.
6. Celli, J., C. de Chastellier, D. M. Franchini, J. Pizarro-Cerda, E. Moreno, and J. P. Gorvel. 2003. Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum. J. Exp. Med. 198:545-556.
7. Checroun, C., T. D. Wehrly, E. R. Fischer, S. F. Hayes, and J. Celli. 2006. Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication. Proc. Natl. Acad. Sci. USA 103:14578-14583.
8. Clemens, D. L., B. Y. Lee, and M. A. Horwitz. 2005. Francisella tularensis enters macrophages via a novel process involving pseudopod loops. Infect. Immun. 73:5892-5902.
9. Clemens, D. L., B. Y. Lee, and M. A. Horwitz. 2004. Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect. Immun. 72:3204-3217.
10. Conlan, J. W. 2004. Vaccines against Francisella tularensis - past, present and future. Expert Rev. Vaccines 3:307-314.
11. de Bruin, O. M., J. S. Ludu, and F. E. Nano. 2007. The Francisella pathogenicity island protein IglA localizes to the bacterial cytoplasm and is needed for intracellular growth. BMC Microbiol. 7:1.
12. Desjardins, M., and G. Griffiths. 2003. Phagocytosis: latex leads the way. Curr. Opin. Cell Biol. 15:498-503.
13. Duclos, S., and M. Desjardins. 2000. Subversion of a young phagosome: the survival strategies of intracellular pathogens. Cell. Microbiol. 2:365-377.
14. Golovliov, I., V. Baranov, Z. Krocova, H. Kovarova, and A. Sjöstedt. 2003. An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells. Infect. Immun. 71:5940-5950.
15. Golovliov, I., A. Sjöstedt, A. Mokrievich, and V. Pavlov. 2003. A method for allelic replacement in Francisella tularensis. FEMS Microbiol. Lett. 222:273-280.
16. Gray, C. G., S. C. Cowley, K. K. M. Cheung, and F. E. Nano. 2002. The identification of five genetic loci of Francisella novicida associated with intracellular growth. FEMS Microbiol. Immunol. 215:53-56.
17. Haas, A. 2007. The phagosome: compartment with a license to kill. Traffic 8:311-330.
18. Keim, P., A. Johansson, and D. M. Wagner. 2007. Molecular epidemiology, evolution, and ecology of Francisella. Ann. N. Y. Acad. Sci. 1105:30-66.
19. Lai, X. H., I. Golovliov, and A. Sjöstedt. 2004. Expression of IglC is necessary for intracellular growth and induction of apoptosis in murine macrophages by Francisella tularensis. Microb. Pathog. 37:225-230.
20. Larsson, P., P. C. F. Oyston, P. Chain, M. C. Chu, M. Duffield, H.-H. Fuxelius, E. Garcia, G. Hälltorp, D. Johansson, K. E. Isherwood, P. D. Karp, E. Larsson, Y. Liu, S. Michell, J. Prior, R. G. Prior, S. Malfatti, A. Sjöstedt, K. Svensson, N. Thompson, L. Vergez, J. K. Wagg, B. W. Wren, L. E. Lindler, S. G. E. Andersson, M. Forsman, and R. W. Titball. 2005. The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nat. Genet. 37:153-159.
21. Lauriano, C. M., J. R. Barker, S. S. Yoon, F. E. Nano, B. P. Arulanandam, D. J. Hassett, and K. E. Klose. 2004. MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival. Proc. Natl. Acad. Sci. USA 101:4246-4249.
22. Lindgren, H., I. Golovliov, V. Baranov, R. K. Ernst, M. Telepnev, and A. Sjöstedt. 2004. Factors affecting the escape of Francisella tularensis from the phagolysosome. J. Med. Microbiol. 53:953-958.
23. Oyston, P. C., A. Sjöstedt, and R. W. Titball. 2004. Tularaemia: bioterrorism defence renews interest in Francisella tularensis. Nat. Rev. Microbiol. 2:967-978.
24. Petrosino, J. F., Q. Xiang, S. E. Karpathy, H. Jiang, S. Yerrapragada, Y. Liu, J. Gioia, L. Hemphill, A. Gonzalez, T. M. Raghavan, A. Uzman, G. E. Fox, S. Highlander, M. Reichard, R. J. Morton, K. D. Clinkenbeard, and G. M. Weinstock. 2006. Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequence. J. Bacteriol. 188:6977-6985.
25. Pierini, L. M. 2006. Uptake of serum-opsonized Francisella tularensis by macrophages can be mediated by class A scavenger receptors. Cell. Microbiol. 8:1361-1370.
26. Pukatzki, S., A. T. Ma, D. Sturtevant, B. Krastins, D. Sarracino, W. C. Nelson, J. F. Heidelberg, and J. J. Mekalanos. 2006. Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc. Natl. Acad. Sci. USA 103:1528-1533.
27. Rohmer, L., C. Fong, S. Abmayr, M. Wasnick, T. J. Larson Freeman, M. Radey, T. Guina, K. Svensson, H. S. Hayden, M. Jacobs, L. A. Gallagher, C. Manoil, R. K. Ernst, B. Drees, D. Buckley, E. Haugen, D. Bovee, Y. Zhou, J. Chang, R. Levy, R. Lim, W. Gillett, D. Guenthener, A. Kang, S. A. Shaffer, G. Taylor, J. Chen, B. Gallis, D. A. D'Argenio, M. Forsman, M. V. Olson, D. R. Goodlett, R. Kaul, S. I. Miller, and M. J. Brittnacher. 2007. Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains. Genome Biol. 8:R102.
28. Santic, M., M. Molmeret, J. R. Barker, K. E. Klose, A. Dekanic, M. Doric, and Y. Abu Kwaik. 2007. A Francisella tularensis pathogenicity island protein essential for bacterial proliferation within the host cell cytosol. Cell. Microbiol. 9:2391-2403.
29. Santic, M., M. Molmeret, K. E. Klose, S. Jones, and Y. A. Kwaik. 2005. The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm. Cell. Microbiol. 7:969-979.
30. Schulert, G. S., and L. A. Allen. 2006. Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor. J. Leukoc. Biol. 80:563-571.
31. Twine, S., M. Byström, W. Chen, M. Forsman, I. Golovliov, A. Johansson, J. Kelly, H. Lindgren, K. Svensson, C. Zingmark, W. Conlan, and A. Sjöstedt. 2005. A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine. Infect. Immun. 73:8345-8352.
32. Vieira, O. V., R. J. Botelho, and S. Grinstein. 2002. Phagosome maturation: aging gracefully. Biochem. J. 366:689-704.