The effects of endothelin receptor blockade by bosentan on the healing of a bowel anastomosis in an experimental Crohn's disease model

Journal of Gastrointestinal Surgery

Volumn 12, Issue 8, 2008, Pages 1429-1435

  Kirkil, Cuneyt ^a   Cetinkaya, Ziya ^a   Ustundag, Bilal ^a   Akpolat, Nusret ^a   Ayten, Refik ^a   Bulbuller, Nurullah ^a  

^a FIRAT UNIVERSITY   (Turkey)

Author keywords

Bosentan; Crohn's disease; Endothelin; Intestinal anastomosis; Wound healing

Indexed keywords

ANTIHYPERTENSIVE AGENT; BOSENTAN; ENDOTHELIN RECEPTOR; SULFONAMIDE;

ANASTOMOSIS; ANIMAL; ARTICLE; COMPARATIVE STUDY; CROHN DISEASE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; JEJUNUM; MALE; METABOLISM; METHODOLOGY; RAT; SPRAGUE DAWLEY RAT; TREATMENT OUTCOME; WOUND HEALING;

ANASTOMOSIS, SURGICAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; CROHN DISEASE; DISEASE MODELS, ANIMAL; JEJUNUM; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; SULFONAMIDES; TREATMENT OUTCOME; WOUND HEALING;

EID: 48849092141     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-008-0527-6     Document Type: Article

References (28)

1. Wakefield AJ, Sankey EA, Dhillon AP, Sawyerr AM, More L, Sim R, Pittilo RM, Rowles PM, Hudson M, Lewis AA et al. Granulomatous vasculitis in Crohn's disease. Gastroenterology 1991;100:1279-1287.
2. Murch SH, Braegger CP, Sessa WC, MacDonald TT. High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis. Lancet 1992;339:381-385.
3. Akyuz A, Bilsel Y. Crohn HastalIǧI. In Alemdaroglu K, Akcal T, Bugra D, eds. Kolon Rektum ve Anal Bölge HastalIklarI. Istanbul: TasarIm Ofset, 2003, pp 621-643.
4. Clozel M, Breu V, Gray GA, Kalina B, Loffler BM, Burri K, Cassal JM, Hirth G, Muller M, Neidhart W, Ramuz H. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J Pharmacol Exp Ther 1994;270:228-235.
5. Rachmilewitz D, Okon E, Karmeli F. Sulphydryl blocker induced small intestinal inflammation in rats: a new model mimicking Crohn's disease. Gut 1997;41:358-365.
6. Linder MM, Wacha H, Feldmann U, Wesch G, Streifensand RA, Gundlach E. The Mannheim peritonitis index. An instrument for the intraoperative prognosis of peritonitis. Chirurg 1987;58:84-92.
7. Mei Q, Yu JP, Xu JM, Wei W, Xiang L, Yue L. Melatonin reduces colon immunological injury in rats by regulating activity of macrophages. Acta Pharmacol Sin 2002;23:882-886.
8. Woessner JF. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961;93:440-447.
9. Shibata Y, Taruishi M, Ashida T. Experimental ileitis in dogs and colitis in rats with trinitrobenzene sulfonic acid - colonoscopic and histopathological studies. Gastroenterol Jpn 1993;28:518-527.
10. Osborne MJ, Hudson M, Piasecki C, Dhillon AP, Lewis AAM, Pounder RE, Wakefield AJ. Crohn's disease and anastomotic recurrence: microvascular ischemia and anastomotic healing in an animal model. Br J Surg 1993;80:226-229.
11. Hogaboam CM, Muller MJ, Collins SM, Hunt RH. An orally active non-selective endothelin receptor antagonist, bosentan, markedly reduces injury in a rat model of colitis. Eur J Pharmacol 1996;309:261-269.
12. Sessa WC, Kaw S, Hecker M, Vane JR. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun. 1991;174:613-618.
13. Yoshizumi M, Kurihara H, Morita T, Yamashita T, Oh-hashi Y, Sugiyama T, Takaku F, Yanagisawa M, Masaki T, Yazaki Y. Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells. Biochem Biophys Res Commun 1990;166:324-329.
14. Rachmilewitz D, Simon PL, Schwartz LW, Griswold DE, Fondacaro JD, Wasserman MA. Inflammatory mediators of experimental colitis in rats. Gastroenterology 1989;97:326-337.
15. Filep JG, Clozel M, Fournier A, Foldes-Filep E. Characterization of receptors mediating vascular responses to endothelin-1 in the conscious rat. Br J Pharmacol 1994;113:845-852.
16. Boros M, Massberg S, Baranyi L, Okada H, Messmer K. Endothelin-1 induces leukocyte adhesion in submucosal venules of the rat small intestine. Gastroenterology 1998;114:103-114.
17. Cetinkaya Z, Esen K, Ozercan IH, Ustundag B, Ayten R, Aygen E. The effect of Bosentan on healing of colonic anastomosis. World J Emerg Surg 2006;1:37.
18. Rockey DC, Chung JJ. Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing. J Clin Invest 1996;98:1381-1388.
19. Hocher B, Schwarz A, Fagan KA, Thöne-Reineke C, El-Hag K, Kusserow H, Elitok S, Bauer C, Neumayer HH, Romdan DM, Theuring F. Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice. Am J Respir Cell Mol Biol 2000;23:19-26.
20. A receptor in cultured human cardiac fibroblasts. Cell Physiol Biochem 2004;14:285-292.
21. Akimoto M, Hashimoto H, Maeda A, Shigemoto M, Yamashita K. Roles of angiogenic factors and endothelin-1 in gastric ulcer healing. Clin Sci 2002;103:S450-S454.
22. Kanazawa S, Tsunoda T, Onuma E, Majima T, Kagiyama M, Kikuchi K. VEGF, basic-FGF, and TGF-b in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. Am J Gastroenterol 2001;96:822-828.
23. McCartney SA, Ballinger AB, Vojnovic I, Farthing MJG, Warner TD. Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis. Life Sci 2002;71:1893-1904.
24. King-VanVlack CE, Mewburn JD, Chapler CK, MacDonald PH. Hemodynamic and proinflammatory actions of endothelin-1 in guinea pig small intestine submucosal microcirculation. Am J Physiol Gastrointest Liver Physiol 2003;284:G940-G948.
25. Solomkin JS, Wittman DW, West MA, Barie PS. Intraabdominal infections. In Schwartz SI, Shires GT, Spencer FC, Daly JM, Fischer JE, Galloway AC, eds. Principles of surgery. New York: McGraw-Hill International, 1999, pp 1515-1550.
26. Lundblad R, Giercksky KE. Effect of volume support, antibiotic therapy, and monoclonal antiendotoxin antibodies on mortality rate and blood concentrations of endothelin and other mediators in fulminant intra-abdominal sepsis in rats. Crit Care Med 1995;23:1382-1390.
27. Lundblad R, Giercksky KE. Endothelin concentrations in experimental sepsis: profiles of big endothelin and endothelin 1-21 in lethal peritonitis in rats. Eur J Surg 1995;161:9-16.
28. Metsarinne KP, Vehmaan-Kreula P, Kovanen PT, Saijonmaa O, Baumann M, Wang Y, Nyman T, Fyhrquist FY, Eklund KK. Activated mast cells increase the level of endothelin-1 mRNA in cocultured endothelial cells and degrade the secreted peptide. Arterioscler Thromb Vasc Biol 2002;22:268-273.