An orally active non-selective endothelin receptor antagonist, bosentan, markedly reduces injury in a rat model of colitis

European Journal of Pharmacology

Volumn 309, Issue 3, 1996, Pages 261-269

  Hogaboam, Cory M ^a,b   Muller, Milan J ^a   Collins, Stephen M ^a   Hunt, Richard H ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

Bosentan; Endothelin; Inflammatory bowel disease; Intestinal inflammation

Indexed keywords

BOSENTAN; ENDOTHELIN RECEPTOR ANTAGONIST; MYELOPEROXIDASE; TRINITROBENZENESULFONIC ACID;

ANIMAL MODEL; ARTICLE; CELL ADHESION; COLITIS; CONTROLLED STUDY; DESCENDING COLON; ENTERITIS; HISTOCHEMISTRY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PERITONEAL CAVITY; PRIORITY JOURNAL; RAT; ULCER;

EID: 0030586733     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00276-2     Document Type: Article

References (32)

1. Brown, M.A. and P.L. Smith, 1991, Endothelin: a potent stimulator of intestinal ion secretion in vitro, Reg, Peptides 36, 1.
2. Clozel, M., V. Breu, O.A. Gray, B. Kalina, B.-M. Loffler, K. Burri, J.-M. Cassal, G. Hirth, M. Muller, W. Niedhart and H. Ramuz, 1994, Pharmacological characterization of bosentan, a new potent orally active non-peptide endothelin receptor antagonist. J. Pharmacol. Exp. Ther. 270, 228.
3. B receptor mediates both vasodilation and vasoconstriction in vivo, Bochem. Biophys. Res. Commun. 186, 867.
4. B receptors, Br. J. Pharmacol. 115, 227 (Abstract).
5. Hirata, Y., H. Yoshimi, S. Takata, T.X. Watanabe, K. Kumagai, K. Nakajima and S. Sakakibara, 1988, Cellular mechanism of action by a novel vasoconstrictor endotheltn in cultured rat vascular smooth muscle cells, Biochem. Biophys. Res. Commun. 154, 868.
6. Hogaboam, C.M., K. Jacobson, S.M. Collins and MG. Blennerhassett, 1995, The selective beneficial effects of nitric oxide inhibition in experimental colitis, Am. J. Physiol. Gastrointest. Liver Physiol. 268, G673.
7. 25I endothelin-1 binding in normal human intestine and inflammatory bowel disease, Gastroenterology 108, A2583 (Abstract).
8. Inagaki, H., A.E. Bishop, C. Escrig, J. Wharton, T.G. Allen-Mersh and J.M. Polak, 1991, Localization of endothelin-like immunoreactivity and endothelin binding sites in human colon, Gastroenterology 101, 47.
9. Inoue, A., M. Yanagisawa, S. Kimura, Y. Kasuya, T. Miyauchi, K. Goto and T. Masaki, 1989, The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes, Proc. Natl. Acad. Sci. USA 86, 2863.
10. Katajima, T., T. Yamaguchi, K. Tani, Y. Kubota, M. Okuhira, K. Inoue and H. Yamada, 1993, Role of endothelin and platelet-activating factor in indomethacin-induced gastric mucosal injury in rats. Digestion 54, 156.
11. Kitsukawa, Y., Z.-F. Gu, P. Hildebrand and R.T. Jensen, 1994, Gastric smooth muscle cells possess two classes of endothelin receptors but only one alters contraction. Am. J. Physiol. Gastrointest. Liver Physiol. 266, G713.
12. Kiyohara, T., M. Okuno, T. Nakanishi, Y. Shinomura and Y. Matsuzawa, 1993, Effect of endothelin-1 on ion transport in isolated rat colon, Gastroenterology 104, 1328.
13. Lasaratos, S., A. Nakahara, K. Goto and H. Fukutomi, 1995, Bosentan antagonizes the effects of endothelin-1 on rat gastric blood flow and mucosal integrity, Life Sci. 56, 195.
14. Li, J.S., R. Lariviere and E.L. Schiffrin, 1994, Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy. Hypertension 24, 183.
15. Masuda, E., S. Kawano, K. Nagano, S. Tsuji, Y. Takei, N. Hayashi, M. Tsujii, M. Oshita, T. Michada, I. Kobayashi, H.B. Peng, H. Fusamoto and T. Kamada, 1993, Role of endogenous endothelin in the pathogenesis of ethanol-induced gastric mucosal injury in rats, Am. J. Physiol. 265, G474.
16. Michida, T., S. Kawano, E. Masuda, I. Kobayashi, Y. Nishimura, M. Tsujii, N. Hayashi, Y. Takei, S. Tsuji, K, Nagano, H. Fusamoto and T. Kamada, 1994, Role of endothelin-1 in haemorrhagic shock-induced gastric mucosal injury in rats, Gastroenterology 106, 988.
17. Miller, R.C., J.T. Pelton and J.P. Huggins, 1993, Endothelins - from receptors to medicine. TIPS 14, 54.
18. Morris, G.P., P.L. Beck, M.S. Herridge, W.T. Depew, M.R. Szewczuk and J.L. Wallace, 1989, Hapten-induced model of chronic inflammation and ulceration in the rat colon, Gastroenterology 96, 795.
19. Murch, S.H., C.P. Braegger, W.C. Sessa and T.T. MacDonald, 1992, High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis, Lancet 339, 381.
20. Sessa, W.C., S. Kaw, M. Hecker and J.R. Vane, 1991, The biosynthesis of endothelin-1 by human polymorphonuclear leucocytes, Bochem. Biophys. Res. Commun. 174, 613.
21. Stevens, E.J. and D.R. Tomlinson, 1995, Effects of endothelin receptor antagonism with bosentan on peripheral nerve function in experimental diabetes, Br. J. Pharmacol. 115, 373.
22. Takahashi, K., P.M. Jones, S.M. Kanse, H.-C. Lam, R.A. Spokes, M.A. Ghatel and S.R. Bloom, 1990, Endothelin in the gastrointestinal tract. Presence of endothelin-like immunoreactivity, endothelin-1 mRNA, endothelin receptors and pharmacological effect, Gastroenterology 99, 1660.
23. B receptors in canine coronary arteries, Circ. Res. 74, 105.
24. Wakefield, A.J., E.A. Sankey, A.P. Dhillon, A.M. Sawyerr, L. More, R. Sim, M. Pittilo, P.M. Rowles, M. Hudson, A.A.M. Lewis and R.E. Pounder, 1991, Granulomatous vasculitis in Crohn's disease, Gastroenterology 100, 1279.
25. Wakefield, A.J., A.M. Sawyer, A.P. Dhillon, A.P. Pittilo, P.M. Rowles, A.A.M. Lewis and R.E. Pounder, 1989, Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction, Lancet 1, 1057.
26. Wallace, J.L., 1994, Novel targets for anti-inflammatory therapy in inflammatory bowel disease, in: Inflammatory Bowel Disease. Basic Research, Clinical Implications and Trends in Therapy, eds. L.R. Sutherland, S.M. Collins, F. Martin, R.S. McLeod, S.R. Targan, J.L. Wallace and C.N. Williams (Kluwer Academic Publishers, London) p. 374.
27. Wallace, J.L., G. Cirino, G. DeNucci, W. McKnight and W.K. MacNaughton, 1989, Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach, Am. J. Physiol. 256, G661.
28. Wallace, J.L., A. Higa, G.W. McKnight and D.E. MacIntyre, 1992, Prevention and reversal of experimental colitis by a monoclonal antibody which inhibits leucocyte adherence, Inflammation 16, 343.
29. Wallace, J.L. and C.M. Keenan, 1990, An orally active inhibitor of leukotriene synthesis accelerates healing in a rat model of colitis, Am. J. Physiol. 258, G527.
30. Whittle, B.J.R. and J.V. Esplugues, 1988, Induction of rat gastric damage by the endothelium-derived peptide, endothelin, Br. J. Pharmacol. 95, 1011.
31. Yamada, T., S. Marshall, R.D. Specian and M.B. Grisham, 1992, A comparative analysis of two models of colitis in rats, Gastroenterology 102, 1524.
32. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto and T. Masaki, 1988, A novel potent vasoconstrictor peptide produced by vascular endothelial cells, Nature (London) 332, 411.