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Volumn 7, Issue 9, 2008, Pages 765-766

Neutralisation of IL12 p40 or IL23 p40 does not block inflammation in multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOLOGIC AGENT; INTERLEUKIN 12P40; INTERLEUKIN 23; INTERLEUKIN 23P40; UNCLASSIFIED DRUG; USTEKINUMAB;

EID: 48849089330     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(08)70174-1     Document Type: Letter
Times cited : (12)

References (9)
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  • 2
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    • The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation
    • Kikly K., Liu L., Na S., and Sedgwick J.D. The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr Opin Immunol 18 (2006) 670-675
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    • Kikly, K.1    Liu, L.2    Na, S.3    Sedgwick, J.D.4
  • 3
    • 21844444831 scopus 로고    scopus 로고
    • New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
    • Hunter C.A. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 5 (2005) 521-531
    • (2005) Nat Rev Immunol , vol.5 , pp. 521-531
    • Hunter, C.A.1
  • 4
    • 25444476685 scopus 로고    scopus 로고
    • Suppression of ongoing disease in a nonhuman primate model of multiple sclerosis by a human-anti-human IL-12p40 antibody
    • 't Hart B.A., Brok H.P.M., Remarque E., et al. Suppression of ongoing disease in a nonhuman primate model of multiple sclerosis by a human-anti-human IL-12p40 antibody. J Immunol 175 (2005) 4761-4768
    • (2005) J Immunol , vol.175 , pp. 4761-4768
    • 't Hart, B.A.1    Brok, H.P.M.2    Remarque, E.3
  • 5
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua D.J., Sherlock J., Chen Y., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003) 744-748
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3
  • 6
    • 48849087125 scopus 로고    scopus 로고
    • Repeated subcutaneous injections of IL12p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised dose-ranging study
    • Segal B.M., Constantinescu C.S., Raychaudhuri A., et al. Repeated subcutaneous injections of IL12p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised dose-ranging study. Lancet Neurol 7 (2008) 796-804
    • (2008) Lancet Neurol , vol.7 , pp. 796-804
    • Segal, B.M.1    Constantinescu, C.S.2    Raychaudhuri, A.3
  • 7
    • 33846472053 scopus 로고    scopus 로고
    • CNS myeloid DCs presenting endogenous myelin peptides preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE
    • Bailey S.L., Schreiner B., McMahon E.J., and Miller S.D. CNS myeloid DCs presenting endogenous myelin peptides preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE. Nat Immunol 8 (2007) 172-180
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    • Bailey, S.L.1    Schreiner, B.2    McMahon, E.J.3    Miller, S.D.4
  • 8
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    • IL-23 produced by CNS-resident cells controls T-cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
    • Becher B., Durell B.G., and Noelle R.J. IL-23 produced by CNS-resident cells controls T-cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. J Clin Invest 112 (2003) 1186-1191
    • (2003) J Clin Invest , vol.112 , pp. 1186-1191
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
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    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • Leonardi C.L., Kimball A.B., Papp K.A., et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 371 (2008) 1665-1674
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.