Evaluation of DNA damage induction on human pulmonary cells exposed to PAHs from organic extract of PM10 collected in a coke-oven plant

Acta Biomedica de l'Ateneo Parmense

Volumn 79, Issue SUPPL. 1, 2008, Pages 97-103

  Cavallo, Delia ^a   Ursini, Cinzia L ^a   Pira, Enrico ^b   Romano, Canzio ^b   Maiello, Raffaele ^a   Petyx, Marta ^a   Iavicoli, Sergio ^a  

^a ISPESL   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Coke plant; Comet assay; Environmental monitoring; Lung epithelial cells; Polycyclic Aromatic Hydrocarbons

Indexed keywords

BENZ[A]ANTHRACENE; BENZO[A]PYRENE; BENZO[B]FLUORANTHENE; BENZO[GHI]PERYLENE; BENZO[K]FLUORANTHENE; DIBENZ[A,H]ANTHRACENE; DNA; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE;

AIR SAMPLING; AIRBORNE PARTICLE; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; FILTER; GAS CHROMATOGRAPHY; GENOTOXICITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MASS SPECTROMETRY; OCCUPATIONAL EXPOSURE; PARTICULATE MATTER;

CELLS, CULTURED; COKE; DNA DAMAGE; EXTRACTION AND PROCESSING INDUSTRY; HUMANS; LUNG; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PARTICULATE MATTER; RESPIRATORY MUCOSA;

EID: 48749116348     PISSN: 03924203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. th Report on Carcinogens. Research Triangle Park, NC: National Toxicology Program, 70-71, 2002.
2. Liu G, Niu Z, Van Niekerk D, Xue J, Zheng L. Polycyclic aromatic hydrocharbons (PAHs) from coal combustion: emissions, analysis, and toxicology. Rev Environ Contam Toxicol 2008; 192: 1-28.
3. IARC, Monographs on the evaluation of carcinogenic risks to humans. Polynuclear Aromatic Compounds, Part 3, Industrial Exposure in Aluminium Production, Coal Gasification, Coke Production, and Iron and Steel Founding, Lyon, vol 34, p 101, 1984.
4. IARC Monograph on the evaluation of carcinogenic risks to humans, Lyon, vol. 92, 2008. In press
5. IARC, Overall evaluations of carcinogenicity: an updating of IARC Monographs, IARC Monogr Eval Carcinogenic risks Human suppl. 7:1-440, 1987.
6. Costantino JP, Redmond CK, Bearden A. Occupationally related cancer risk among coke oven workers: 30 years of follow-up. J Occup Environ Med 1995; 37: 597-604.
7. Bosetti C, Boffetta P, La Vecchia C. Occupational exposures to polycyclic aromatic hydrocarbons and respiratory and urinary tract cancers: a quantitative review to 2005. Ann Oncol 2007; 18/3: 431-46.
8. Armstrong B, Hutchinson E, Unwin J, Fletcher T. Lung cancer risk after exposure to polycyclic aromatic hydrocarbons: a review and meta-analysis. Environ Health Perspect 2004; 112/9: 970-8.
9. Boffetta P, Jourenkova N, Gustavsson P. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control 1997; 8: 444-72.
10. Schell C, Popp W, Kraus R, Vahrenholz C, Norpoth K. 32P-postlabeling analysis of DNA adducts in different populations. Toxicol Lett 1995; 77/1-3: 299-307.
11. Forni A, Guanti G, Bukvic N, Ferri G, Foà V. Cytogenetic studies in coke oven workers. Toxicol Lett 1996; 88/1-3: 185-9.
12. Kalina I, Brezáni P, Gajdosová D,et al. Cytogenetic monitoring in coke oven workers. Mutat Res 1998; 417/1: 9-17.
13. Binková B, Topinka J, Mracková G, et al. Coke oven workers study: the effect of exposure and GSTM1 and NAT2 genotypes on DNA adduct levels in white blood cells and lymphocytes as determined by 32P-postlabelling. Mutat Res 1998; 416/1-2: 67-84.
14. Rojas M, Alexandrov K, Auburtin G, et al. Anti-benzo[a]pyrene diolepoxide - DNA adduct levels in peripheral mononuclear cells from coke oven workers and the enhancing effect of smoking. Carcinogenesis 1995; 16/6: 1373-6.
15. Marczynski B, Rihs HP, Rossbach B, et al. Analysis of 8-oxo-7,8-dihydro-2′-deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms. Carcinogenesis 2002; 23/2: 273-81.
16. Liu AL, Lu WQ, Wang ZZ, et al. Elevated levels of urinary 8-hydroxy-2 -deoxyguanosine, lymphocytic micronuclei, and serum glutathione S-transferase in workers exposed to coke oven emissions. Environ Health Perspect 2006; 114/5: 673-7.
17. Reuterwall C, Aringer L, Elinder CG, et al. Assessment of genotoxic exposure in Swedish coke-oven work by different methods of biological monitoring. Scand J Work Environ Health 1991; 17/2: 123-32.
18. Ovrebø S, Haugen A, Phillips DH, Hewer A. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells from coke oven workers: correlation with job categories. Cancer Res 1992; 52/6: 1510-4.
19. Poncin JM, Klein F, Marquis N, Sowa L, Courcot B, Zabaloueff V. Assessment of biological monitoring of workers exposed to coke-oven plant emissions. Mazieres-les-Metz, France: LECES Environment 1995.
20. van Delft JH, Steenwinkel MS, van Asten JG, et al. Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1. Ann Occup Hyg 2001; 45/5: 395-408.
21. Butler AP, Johnson DG, Kumar AP, Narayan S, Wilson SH, MacLeod MC. Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences. Carcinogenesis 1997; 18/2: 239-44.
22. Frenkel K. Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol Ther 1992; 53/1: 127-66.
23. Pilger A, Rüdiger HW. 8-Hydroxy-2′-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. Int Arch Occup Environ Health 2006; 80/1: 1-15.
24. Collins AR, Duthie J, Dobson VL. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 1999; 14/9: 1733-5.
25. Binková B, Cerná M, Pastorková A,et al. Biological activities of organic compounds adsorbed onto ambient air particles: comparison between the cities of Teplice and Prague during the summer and winter seasons 2000-2001. Mutat Res 2003; 525/1-2: 43-59.
26. Du Four VA, Van Larebeke N, Janssen CR. Genotoxic and mutagenic activity of environmental air samples in Flanders, Belgium. Mutat Res 2004; 558/1-2: 155-67.
27. Gábelová A, Valovicová Z, Horváthová E, et al. Genotoxicity of environmental air pollution in three European cities: Prague, Kosice and Sofia. Mutat Res 2004; 563/1: 49-59.
28. Risom L, Møller P, Loft S. Oxidative stress-induced DNA damage by particulate air pollution. Mutat Res 2005; 592/1-2: 119-37.
29. Gábelová A, Valovicová Z, Bacová G, et al. Sensitivity of different endpoints for in vitro measurement of genotoxicity of extractable organic matter associated with ambient airborne particles (PM10). Mutat Res 2007; 620/1-2: 103-13.
30. Gábelová A, Valovicová Z, Lábaj J, Bacová G, Binková B, Farmer PB. Assessment of oxidative DNA damage formation by organic complex mixtures from airborne particles PM(10). Mutat Res 2007; 620/1-2: 135-44.
31. Sevastyanova O, Binkova B, Topinka J, et al. In vitro genotoxicity of PAH mixtures and organic extract from urban air particles part II: human cell lines. Mutat Res 2007; 620/1-2: 123-34.
32. Cavallo D, Ursini CL, Di Filippo P, et al. Induction of direct-oxidative DNA damage by urban airborne particulate matter. Proceedings of Secotox Conference and International Conference on Environmental Management, Engineering, Planning and Economics (CEMEPE) 2007; pp. 13-18.
33. Carnevali S, Petruzzelli S, Longoni B, et al. Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 2003; 284/6: L955-63.
34. Chen HW, Chien ML, Chaung YH, Lii CK, Wang TS. Extracts from cigarette smoke induce DNA damage and cell adhesion molecule expression through different pathways. Chem Biol Interact 2004; 150/3:233-41.
35. Cavallo D, Ursini CL, Ciervo A, et al. Detection of oxidative DNA damage in A549 cells exposed to smoke extract from commercial cigarettes. Cytometry part A. Special issue 2008; In press.
36. DeMarini DM. Genotoxicity of tobacco smoke and tobacco smoke condensate: a review. Mutat Res 2004; 567/2-3: 447-74.