Collapsing SNP genotypes in case-control genome-wide association studies increases the type I error rate and power

Statistical Applications in Genetics and Molecular Biology

Volumn 7, Issue 1, 2008, Pages

  Matthews, Abigail G ^a   Haynes, Chad ^a   Liu, Chang ^a   Ott, Jurg ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b Chinese Academy of Sciences

Author keywords

Genome wide association; Type I error rate

Indexed keywords

ALLELE; ANALYTIC METHOD; ANALYTICAL ERROR; ARTICLE; CASE CONTROL STUDY; GENE ACTIVITY; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MODEL; GENOME WIDE ASSOCIATION STUDY; GENOTYPE; MATHEMATICAL COMPUTING; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; ANALYSIS OF VARIANCE; BIOLOGICAL MODEL; CHI SQUARE DISTRIBUTION; DNA MICROARRAY; DOMINANT GENE; GENETIC PREDISPOSITION; HUMAN; METHODOLOGY; RECESSIVE GENE; STATISTICS;

ALLELES; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; GENES, DOMINANT; GENES, RECESSIVE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MODELS, GENETIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RESEARCH DESIGN;

EID: 48749108267     PISSN: None     EISSN: 15446115     Source Type: Journal    
DOI: 10.2202/1544-6115.1325     Document Type: Article

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