Activation of endothelial cells to pathological status by down-regulation of connexin43

Cardiovascular Research

Volumn 79, Issue 3, 2008, Pages 509-518

  Wang, Hsueh Hsiao ^a   Kung, Chang I ^a   Tseng, Yuen Yi ^a   Lin, Yi Chun ^a   Chen, Chi Hau ^a   Tsai, Cheng Ho ^a,b,c   Yeh, Hung I ^a,b,c  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; c jun N terminal kinase; Coagulatory factors; Connexins; Gap junctions

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CONNEXIN 43; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; VON WILLEBRAND FACTOR;

ANGIOGENESIS; AORTA; ARTICLE; CELL ACTIVATION; CELL COMMUNICATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; GAP JUNCTION; GENE SEQUENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UPREGULATION;

ANTHRACENES; CELL COMMUNICATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CONNEXIN 43; CONNEXINS; DOWN-REGULATION; ENDOTHELIAL CELLS; GAP JUNCTIONS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDES; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE INHIBITORS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIME FACTORS; VON WILLEBRAND FACTOR;

EID: 48749105513     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn112     Document Type: Article

References (39)

1. Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004;109:III27-III32.
2. Evans WH, De Vuyst E, Leybaert L. The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J 2006;397:1-14.
3. Van RH, van Kempen MJ, Analbers LJ, Rook MB, van Ginneken AC, Gros D et al. Gap junctions in human umbilical cord endothelial cells contain multiple connexins. Am J Physiol 1997;272:C117-C130.
4. Yeh HI, Rothery S, Dupont E, Coppen SR, Severs NJ. Individual gap junction plaques contain multiple connexins in arterial endothelium. Circ Res 1998;83:1248-1263.
5. van Rijen HV, van Kempen MJ, Postma S, Jongsma HJ. Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells. Cytokine 1998;10:258-264.
6. Tsai CH, Yeh HI, Tian TY, Lee YN, Lu CS, Ko YS. Down-regulating effect of nicotine on connexin43 gap junctions in human umbilical vein endothelial cells is attenuated by statins. Eur J Cell Biol 2004;82:589-595.
7. Vergara L, Bao X, Cooper M, Bello-Reuss E, Reuss L. Gap-junctional hemichannels are activated by ATP depletion in human renal proximal tubule cells. J Membr Biol 2003;196:173-184.
8. Contreras JE, Sanchez HA, Eugenin EA, Speidel D, Theis M, Willecke K et al. Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci USA 2002;99:495-500.
9. Maass K, Ghanem A, Kim JS, Saathoff M, Urschel S, Kirfel G et al. Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43. Mol Biol Cell 2004;15:4597-4608.
10. Singh D, Solan JL, Taffet SM, Javier R, Lampe PD. Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. J Biol Chem 2005;280:30416-30421.
11. Giepmans BN. Gap junctions and connexin-interacting proteins. Cardiovasc Res 2004;62:233-245.
12. Boengler K, Dodoni G, Rodriguez-Sinovas A, Cabestrero A, Ruiz-Meana M, Gres P et al. Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc Res 2005;67:234-244.
13. Goubaeva F, Mikami M, Giardina S, Ding B, Abe J, Yang J. Cardiac mitochondrial connexin 43 regulates apoptosis. Biochem Biophys Res Commun 2007;352:97-103.
14. Yeh HI, Chang HM, Lu WW, Lee YN, Ko YS, Severs NJ et al. Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium. J Histochem Cytochem 2000;48:1377-1389.
15. Yeh HI, Lee PY, Su CH, Tian TY, Ko YS, Tsai CH. Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment. Am J Hypertens 2006;19:129-135.
16. Sato T, Haimovici R, Kao R, Li AF, Roy S. Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells. Diabetes 2002;51:1565-1571.
17. Liao Y, Day KH, Damon DN, Duling BR. Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice. Proc Natl Acad Sci USA 2001;98:9989-9994.
18. Sumara G, Belwal M, Ricci R. 'Jnking' atherosclerosis. Cell Mol Life Sci 2005;62:2487-2494.
19. Chaytor AT, Evans WH, Griffith TM. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol 1997;503:99-110.
20. Shao Q, Wang H, McLachlan E, Veitch GI, Laird DW. Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. Cancer Res 2005;65:2705-2711.
21. Elfgang C, Eckert R, Lichtenberg-Frate H, Butterweck A, Traub O, Klein RA et al. Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J Cell Biol 1995;129:805-817.
22. Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res 2007;101:59-68.
23. Hoefen RJ, Berk BC. The role of MAP kinases in endothelial activation. Vascul Pharmacol 2002;38:271-273.
24. Omura T, Yoshiyama M, Matsumoto R, Kusuyama T, Enomoto S, Nishiya D et al. Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression. J Mol Cell Cardiol 2005;38:583-592.
25. Vulin AI, Stanley FM. Oxidative stress activates the plasminogen activator inhibitor type 1 (PAI-1) promoter through an AP-1 response element and cooperates with insulin for additive effects on PAI-1 transcription. J Biol Chem 2004;279:25172-25178.
26. Rush S, Khan G, Bamisaiye A, Bidwell P, Leaver HA, Rizzo MT. c-Jun amino-terminal kinase and mitogen activated protein kinase 1/2 mediate hepatocyte growth factor-induced migration of brain endothelial cells. Exp Cell Res 2007;313:121-132.
27. McIlroy M, O'Rourke M, McKeown SR, Hirst DG, Robson T. Pericytes influence endothelial cell growth characteristics: role of plasminogen activator inhibitor type 1 (PAI-1). Cardiovasc Res 2006;69:207-217.
28. Leik CE, Su EJ, Nambi P, Crandall DL, Lawrence DA. Effect of pharmacologic plasminogen activator inhibitor-1 inhibition on cell motility and tumor angiogenesis. J Thromb Haemost 2006;4:2710-2715.
29. McLachlan E, Shao Q, Wang HL, Langlois S, Laird DW. Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis. Cancer Res 2006;66:9886-9894.
30. Mori R, Power KT, Wang CM, Martin P, Becker DL. Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration. J Cell Sci 2006;119:5193-5203.
31. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004;114:1752-1761.
32. Lee KW, Lip GY, Tayebjee M, Foster W, Blann AD. Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes. Blood 2005;105:526-532.
33. Bernardo A, Ball C, Nolasco L, Moake JF, Dong JF. Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow. Blood 2004;104:100-106.
34. Fernandes R, Girao H, Pereira P. High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism. J Biol Chem 2004;279:27219-27224.
35. Yeh HI, Lu CS, Wu YJ, Chen CC, Hong RC, Ko YS et al. Reduced expression of endothelial connexin37 and connexin40 in hyperlipidemic mice: recovery of connexin37 after 7-day simvastatin treatment. Arterioscler Thromb Vasc Biol 2003;23:1391-1397.
36. Chou Y, Tsai CH, Ueng KC, Tian TY, Chen SC, Yeh HI. Endothelial gap junctions are down-regulated by arsenic trioxide. Eur J Pharmacol 2007;569:29-36.
37. Yeh HI, Lai YJ, Chang HM, Ko YS, Severs NJ, Tsai CH. Multiple connexin expression in regenerating arterial endothelial gap junctions. Arterioscler Thromb Vasc Biol 2000;20:1753-1762.
38. Chadjichristos CE, Derouette JP, Kwak BR. Connexins in atherosclerosis. Adv Cardiol 2006;42:255-267.
39. Weber C, Fraemohs L, Dejana E. The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol 2007;7:467-477.