Ginsenoside Re attenuate β-amyloid and serum-free induced neurotoxicity in PC12 cells

Journal of Ethnopharmacology

Volumn 107, Issue 1, 2006, Pages 48-52

  Ji, Z N ^a   Dong, T T X ^b   Ye, W C ^c   Choi, R C ^b   Lo, C K ^b   Tsim, K W K ^b  

^a WANNAN MEDICAL COLLEGE   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c JINAN UNIVERSITY   (China)

Author keywords

Amyloid peptide; Ginsenoside Re; Neuroprotection; PC 12 cells; Serum free medium

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMYLOID BETA PROTEIN; GINSENOSIDE RE; LACTATE DEHYDROGENASE;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL STRAIN; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG EFFECT; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; RAT; SERUM;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN; ANIMALS; CULTURE MEDIA, SERUM-FREE; GINSENOSIDES; L-LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENTS; PANAX; PC12 CELLS; RATS;

EID: 33745820864     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.02.004     Document Type: Article

References (25)

1. Ayasolla K.R., Singh A.K., and Singh I. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and A beta-peptide-induced inflammatory mediators in astroglia. Journal of Neuroinflammation 2 (2005) 21
2. 4, a genuine dammarane glycoside from Korean red ginseng. Planta Medica 62 (1996) 86-87
3. Beka S., Rela K., Dan F., and Eilat H.A. Disaggregation of Alzheimer β-amyloid by site-directed mAb. Proceedings of the National Academy of Science USA, 94 (1997) 4109-4112
4. Buettner C., Yeh G.Y., Phillips R.S., Mittleman M.A., and Kaptchuk T.J. Systematic review of the effects of ginseng on cardiovascular risk factors. The Annals of Pharmacotherapy 40 (2006) 83-95
5. Chen X. Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clinical and Experimental Pharmacology & Physiology 23 (1996) 728-732
6. Chen X., Salwinski S., and Lee T.J.F. Extracts of Ginko biloba and ginsenoside exert cerebral vasorelaxation via a nitric oxide pathway. Clinical and Experimental pharmacology & Physiology 24 (1997) 958-959
7. Chu G.X., and Chen X. Anti-lipid peroxidation and protection of ginsenosides against ischemia and reperfusion injuries in rats. Acta Pharmacologica Sinica 11 (1990) 119-123
8. Findeis M.A. Approaches to discovery and characterization of inhibitors of amyloid-beta-peptide polymerization. Biochimica et Biophysica Acta 1502 (2000) 76-84
9. Gillis C.N. Panax ginseng pharmacology: a nitric oxide link?. Biochemical Pharmacology 54 (1997) 1-8
10. Goins W.F., Lee K.A., Cavalcoli J.D., O'Malley M.E., Dekosky S.T., Fink D.J., et al. Herpes simplex virus type 1 vector-mediated expression of nerve growth factor protects dorsal root ganglion neurons from peroxide toxicity 73 (1999) 519-532
11. Iverson L.L., Mortishire-Smith R.J., Pollack S.J., and Shearman M.S. The toxicity in vitro of beta-amyloid protein. Biochemical Journal 311 (1995) 1-16
12. Ji Z.N., and Liu G.Q. Inhibition of serum deprivation-induced PC12 cell apoptosis by tanshinone A. Acta Pharmacologica Sinica 22 (2001) 459-462
13. Ji Z.N., and Liu G.Q. Daidzin protects PC12 cells from serum deprivation-induced apoptosis. Journal Asian Natural Products Research 4 (2002) 265-269
14. Kawahara M., and Kuroda Y. Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis. Brain Research Bulletin 53 (2000) 389-397
15. Pereira C., Agostinho P., Moreira P.I., Cardoso S.M., and Oliveira C.R. Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies. Current Drug Targets: CNS and Neurological Disorders 4 (2005) 383-403
16. Pieralisi G., Ripari P., and Vecchiet L. Effect of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals and trace elements in physical performance during exercise. Clinical Therapeutics 13 (1991) 373-382
17. Selkoe D.J. Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease. Trends in Neuroscience 16 (1993) 403-409
18. Selkoe D.J. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399 (1999) A23-A31
19. Seong Y.H., and Kim H.S. Inhibitory effects of ginseng total saponins on hypoxia-induced dysfunction and injuries of culturedastrocytes. Archives Pharmacology Research 2 (1997) 103-109
20. Shearman M.S., Ragan C.I., and Iverson L.L. Inhibition of PC 12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death. Proceedings of the National Academy of Science USA 91 (1994) 1470-1474
21. Takagi K., Saito H., and Nabata H. Pharmacological studies of Panax ginseng root. The Japanese Journal of Pharmacology 22 (1972) 245-259
22. Toh H.T. Improved isolated heart contractility and mitochondrial oxidation after chronic treatment with Panax ginseng in rats. American Journal of Chinese Medicine 22 (1994) 275-284
23. Yan S.D., Chen X., Fu J., Chen M., Zhu H., Roher A., et al. An intracellular protein the binds amyloid-beta-peptide and mediates neurotoxicity in Alzheimer's disease. Nature 382 (1997) 685-691
24. Yankner B.A., Duffy L.K., and Kischner D.A. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250 (1990) 279-282
25. Zhao W.Q., Williams Z., Shepherd K.R., Reuben J.S., Lee E.S., et al. S-Adenosyl-methionine-induced apoptosis in PC12 cells. Journal Neuroscience Research 69 (2002) 519-529