An indole-binding site is a major determinant of the ligand specificity of the GABA type A receptor-associated protein GABARAP

ChemBioChem

Volumn 9, Issue 11, 2008, Pages 1767-1775

  Thielmann, Yvonne ^a,b   Mohrlüder, Jeannine ^a,b   Koenig, Bernd W ^a,b   Stangler, Thomas ^a,b,c   Hartmann, Rudolf ^a   Becker, Karin ^a   Höltje, Hans Dieter ^b   Willbold, Dieter ^a,b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

GABARAP; Indole binding pocket; Molecular modeling; Molecular recognition; NMR Spectroscopy

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ASSOCIATED PROTEIN; ALANINE; CALRETICULIN; CLATHRIN HEAVY CHAIN; INDOLE; INDOLE DERIVATIVE; RECEPTOR PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; HUMAN; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; HUMANS; HYDROPHOBICITY; INDOLES; LIGANDS; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, GABA-A; SUBSTRATE SPECIFICITY; TITRIMETRY; TRYPTOPHAN;

EID: 48749090506     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800117     Document Type: Article

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