Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4688-4691

  Win, Nwet Nwet ^a   Awale, Suresh ^a   Esumi, Hiroyasu ^b   Tezuka, Yasuhiro ^a   Kadota, Shigetoshi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

Anti austerity strategy; Kayea assamica; PANC 1; Pancreatic cancer; Preferential cytotoxicity

Indexed keywords

ANTINEOPLASTIC AGENT; KAYEASSAMIN A; KAYEASSAMIN B; UNCLASSIFIED DRUG;

ANAEROBIC CAPACITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CELL MIGRATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG INHIBITION; DRUG ISOLATION; FLOWER; HUMAN; HUMAN CELL; KAYEA ASSAMICA; MEDICINAL PLANT; MYANMAR; PANCREAS CANCER; STRUCTURE ACTIVITY RELATION; WOUND CLOSURE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CLUSIACEAE; COUMARINS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLOWERS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MONOTERPENES; MYANMAR; PANCREATIC NEOPLASMS; PLANT EXTRACTS;

KAYEA ASSAMICA;

EID: 48649110502     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.001     Document Type: Article

References (23)

1. National Cancer Center, Cancer statistics in Japan 2007. http://ganjoho.ncc.go.jp/public/statistics/backnumber/2007_en.html.
2. Tsukuma H., Ajiki W., Ioka A., and Oshima A. Jpn. J. Clin. Oncol. 36 (2006) 602
3. Heinemann V. Oncology 60 (2001) 8
4. Izuishi K., Kato K., Ogura T., Kinoshita T., and Esumi H. Cancer Res. 60 (2000) 6201
5. Koito K., Namieno T., Nagakawa T., and Morita K. Am. J. Roentgenol. 169 (1997) 1263
6. Esumi H., Izuishi K., Kato K., Hashimoto K., Kurashima Y., Kishimoto A., Ogura T., and Ozawa T. J. Biol. Chem. 277 (2002) 32791
7. Esumi H., Lu J., Kurashima Y., and Hanaoka T. Cancer Sci. 95 (2004) 685
8. Awale S., Lu J., Kalauni S.K., Kurashima Y., Tezuka Y., Kadota S., and Esumi H. Cancer Res. 66 (2006) 1751
9. Awale S., Nakashima E.M.N., Kalauni S.K., Tezuka Y., Kurashima Y., Lu J., Esumi H., and Kadota S. Bioorg. Med. Chem. Lett. 16 (2006) 581
10. Win N.N., Awale S., Esumi H., Tezuka Y., and Kadota S. J. Nat. Prod. 70 (2007) 1582
11. Win N.N., Awale S., Esumi H., Tezuka Y., and Kadota S. Chem. Pharm. Bull. 56 (2008) 491
12. Chung C.Y., Murphy-Ullrich J.E., and Erickson H.P. Mol. Biol. Cell 7 (1996) 883
13. 6, 442.2355).
14. Lee K.H., Chai H.B., Tamez P.A., Pezzuto J.M., Cordell G.A., Win K.K., and Tin-Wa M. Phytochemistry 64 (2003) 535
15. Ohtani I., Kusumi T., Kashman Y., and Kakisawa H. J. Am. Chem. Soc. 113 (1991) 4092
16. Rieser M.J., Hui Y.H., Rupprecht J.K., Kozlowski J.F., Wood K.V., McLaughlin J.L., Hanson P.R., Zhuang Z., and Hoye T.R. J. Am. Chem. Soc. 114 (1992) 10203
17. +).
18. 6, 442.2355).
19. Crombie L., Jones R.C.F., and Palmer C.J. J. Chem. Soc., Perkin Trans. 1 (1987) 317
20. +).
21. 100 in NDM.
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23. 2 and 95% air for 24 h. After 24 h incubation, the wound was induced by scrapping the confluent monolayers with a micropipette tip, washed with PBS, and examined on films under a phase-contrast microscope. The test sample (300 μL) at a concentration of 1 μM, which was dissolved in DMSO and prepared in DMEM, was then added into the well. The closure rate of induced wound was compared between compound-treated and control (compound-untreated) groups. Photographs were taken under 100× magnification using phase-contrast microscopy at 0, 48, and 72 h, respectively.