A convenient one-step synthesis of l-aminotryptophans and improved synthesis of 5-fluorotryptophan

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4508-4510

  Winn, Michael ^a   Roy, Abhijeet Deb ^a   Grüschow, Sabine ^a   Parameswaran, Raj S ^b   Goss, Rebecca J M ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b BHARATHIAR UNIVERSITY   (India)

Author keywords

Aminotryptophan; Biotransformation; Halotryptophan; Preparation; Tryptophan synthase

Indexed keywords

5 FLUOROTRYPTOPHAN; TRYPTOPHAN DERIVATIVE; TRYPTOPHAN SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; FREEZE DRYING; ONE POT SYNTHESIS;

BIOCHEMISTRY; BIOTRANSFORMATION; CHEMISTRY, ORGANIC; DRUG COMPOUNDING; DRUG DESIGN; DRUG STABILITY; FREEZE DRYING; MODELS, CHEMICAL; TRYPTOPHAN; TRYPTOPHAN SYNTHASE;

EID: 48649108819     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.053     Document Type: Article

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27. Pelleted cells were washed with saturated NaCl, then resuspended in lysis buffer for cell lysis by sonication. Cell debris was removed by centrifugation. Lysis buffer: Tris-HCl (0.5 M), β-mercaptoethanol (10 mM), EDTA (5 mM), PMSF (1 mM), pH 7.8.
28. Per 100 ml potassium phosphate buffer (0.1 M, pH 7.8): serine (0.127 g, 1.21 mmol), aminoindole (0.160 g, 1eq), PLP (0.8 mg), 2 ml protein extract in dialysis tubing. Ref. 13 gives a detailed procedure.
29. 2 m/z 220.1081.