Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4495-4498

  Hudson, Sarah ^a   Kiankarimi, Mehrak ^a   Eccles, Wendy ^a   Mostofi, Yalda S ^a   Genicot, Marc J ^a   Dwight, Wesley ^a   Fleck, Beth A ^a   Gogas, Kathleen ^a   Wade, Warren S ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

Norepinephrine; Serotonin

Indexed keywords

ATOMOXETINE; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; HETEROCYCLIC COMPOUND; NORADRENALIN UPTAKE INHIBITOR;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

CHEMISTRY, PHARMACEUTICAL; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; DRUG DESIGN; HUMANS; INDENES; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; MODELS, CHEMICAL; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROPYLAMINES; SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 48649108672     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.050     Document Type: Article

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