Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4554-4557

  Torbeev, Vladimir Yu ^a,b   Mandal, Kalyaneswar ^a,b   Terechko, Valentina A ^a,b   Kent, Stephen B H ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Aspartic proteases; Chemical protein synthesis; HIV 1 protease; Ketomethylene isostere

Indexed keywords

AMINO ACID DERIVATIVE; CARBENE; KETOMETHYLENE ISOSTERE; PROTEIN P2; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME DEGRADATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDRATION; HYDROGEN BOND; MOLECULAR MECHANICS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CHEMISTRY, PHYSICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NUCLEOCAPSID; PEPTIDE FRAGMENTS; PEPTIDE HYDROLASES; PROTEIN CONFORMATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 48649102960     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.039     Document Type: Article

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