Local heparin is superior to systemic heparin in preventing arterial thrombosis

Microsurgery

Volumn 22, Issue 6, 2002, Pages 265-272

  Andresen, Dorthe M ^a,c   Barker, John H ^b   Hjortdal, Vibeke E ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b University of Louisville School of Medicine   (United States)

^c NONE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10; HEPARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; HEMOSTASIS; MALE; MICROVASCULAR SURGERY; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RAT; THROMBUS;

ADMINISTRATION, TOPICAL; ANIMALS; ANTICOAGULANTS; FACTOR XA; FEMORAL ARTERY; HEMOSTASIS; HEPARIN; INJECTIONS, INTRAVENOUS; MALE; MODELS, ANIMAL; PARTIAL THROMBOPLASTIN TIME; RANDOM ALLOCATION; RATS; RATS, WISTAR; SINGLE-BLIND METHOD; THROMBOSIS; TRANSILLUMINATION;

EID: 0036378642     PISSN: 07381085     EISSN: None     Source Type: Journal    
DOI: 10.1002/micr.10048     Document Type: Article

References (32)

1. Khouri RK, Cooley BC, Kunselman AR, Landis JR, Yeramian P, Ingram D, Natarajan N, Benes CO, Wallemark C. A prospective study of microvascular free-flap surgery and outcome. Plast Reconstr Surg 1998;102:711-721.
2. Salemark L. International survey of current microvascular practices in free tissue transfer and replantation surgery. Microsurgery 1991;12:308-311.
3. Fukui A, Tamai S. Present status of replantation in Japan. Microsurgery 1994;15:842-847.
4. Johnson PC, Barker JH. Thrombosis and antithrombotic therapy in microvascular surgery. Clin Plast Surg 1992;19:799-807.
5. Toft G, Ravn HB, Hjortdal VE. Intravenously and topically applied magnesium in the prevention of arterial thrombosis. Thromb Res 2000;99:61-69.
6. Ravn HB, Kristensen SD, Hjortdal VE, Thygesen K, Husted SE. Early administration of intravenous magnesium inhibits arterial thrombus formation. Arterioscler Thromb Vasc Biol 1997;17: 3620-3625.
7. Sorensen HB, Kristensen AT, Ravn HB, Fuglsang J, Hjortdal VE. Local application of FFR-rFVIIa reduces thrombus formation at arterial anastomosis in rats. Microsurgery 1999;19:369-373.
8. Khouri RK, Sherman R, Buncke HJ Jr, Feller AM, Hovius S, Benes CO, Ingram DM, Natarajan NN, Sherman JW, Yeramian PD, Cooley BC. A phase 11 trial of intraluminal irrigation with recombinant human tissue factor pathway inhibitor to prevent thrombosis in free flap surgery. Plast Reconstr Surg 2002;107:408-415.
9. Lykoudis EG, Panayotou PN, Stamatopoulos CN, Frangia KB, Papalois AE, Ioannovich JD. Microvascular repair following a modified crush-avulsion injury in a rat model: effect of recombinant human tissue-type plasminogen activator on the patency rate. Microsurgery 2002;20:52-58.
10. Porte RJ, Jong E, Knot EAR, de Maat PM, Terpstra OT, Urk H, Groenland HN. Monitoring heparin and haemostasis during reconstruction of the abdominal aorta. Eur J Vasc Surg 1987;1: 397-402.
11. Barker JH, Acland RD, Anderson GL, Patel J. Microcirculatory disturbances following the passage of emboli in an experimental free-flap model. Plast Reconstr Surg 1992;90:95-102.
12. Acland RD. Thrombus formation in microvascular surgery: an experimental study of the effects of surgical trauma. Surgery 1973;73:766-771.
13. Andresen DM, O'Shaughnessy MM, Acland RD, Anderson GL, Schuscke D, Banis JC, Barker JH. Direct visualization and measurement of microsurgically induced thromboembolism. Microsurgery 1994;15:413-420.
14. Barker JH, Andresen DM, Anderson GL, Schuschke D, Gu J-M, Gupta S, Hjortdal VE, Derr JW, Banis JC, Acland RD. Can varying flow velocity across an arterial anastomosis prevent thromboembolic injury? Microsurgery 1995;16:349-356.
15. Fuglsang J, Ravn HB, Toft GE, Thorwest M, Husted SE, Hjortdal VE. Intravenous acetylsalicylic acid, magnesium and their combination in experimental arterial thrombosis in rats. Blood Coag Fibrinol 1999;10:351-357.
16. Teien AN, Lie M, Abildgaard U. Assay of heparin in plasma using chromogenic substrate for activated factor X. Thromb Res 1976;8:413-416.
17. Mätzsch T, Bergqvist D, Hedner U, Ostergaard P. Effects of an enzymatically depolymerized heparin as compared with conventional heparin in healthy volunteers. Thromb Haemost 1987;57: 97-101.
18. Braam MJ, Cooley BC, Gould JS. Topical heparin enhances patency in a rat model of arterial thrombosis. Ann Plast Surg 1995; 34:148-153.
19. Fu K, Izquierdo R, Walenga JM, Fareed J. Comparative study on the use of anticoagulants heparin and recombinant hirudin in a rabbit traumatic anastomosis model. Thromb Res 1995;78:421-428.
20. Rooks MD, Rodriguez J Jr. Blechner M. Zusmanis K, Hutton W. Comparative study of intraarterial and intravenous anticoagulants in microvascular anastomoses. Microsurgery 1994;15:123-129.
21. Cox GW, Runnels S, Hsu HS-H, Das SK. A comparison of heparinized saline irrigation solutions in a model of microvascular thrombosis. Br J Plast Surg 1992;45:345-348.
22. Tomaru T, Nakamura F, Fujimori Y, Omata M, Kawai S, Okada R, Murata Y, Uchida Y. Local treatment with antithrombotic drugs can prevent thrombus formation: an angioscopic and angiografic study. J Am Coll Cardiol 1995;26:1325-1332.
23. Roux S, Tschopp TB, Baumgartner HR. Effects of Napsagatran (Ro 46-6240), a new synthetic thrombin inhibitor and of heparin in a canine model of coronary artery thrombosis: comparison with an ex vivo annular perfusion chamber model. J Pharmacol Exp Ther 1996;277:71-78.
24. Hupkens P, Cooley BC. Comparison of arterial and venous patency in a rat model of subendothelium-stimulated thrombosis. Microsurgery 1996;17:226-229.
25. Carteaux JP, Gast A, Tschopp TB, Roux S. Activated clotting time as an appropriate test to compare heparin and direct thrombin inhibitors such as hirudin or Ro 46-6240 in experimental arterial thrombosis. Circulation 1995;91:1568-1574.
26. Khouri RK, Cooley BC, Kenna DM, Edstrom LE. Thrombosis of microvascular anastomoses in traumatized vessels: fibrin versus platelets. Plast Reconstr Surg 1990;86:110-117.
27. Ravn HB, Toff GE, Andresen DM. In vivo measurement of arterial thrombus formation in rats. Blood Coag Fibrinol 1996; 7:412.
28. Arnljots B, Dougan P, Bergqvist D. Antithrombotic and platelet activating effects of heparin in prevention of microarterial thrombosis. Plast Reconstr Surg 1997;99:1122-1128.
29. Francis CW, Marder VJ. Increased resistance to plasmic degradation of fibrin with highly crosslinked alfa-polymer chains formed at high factor XIII concentrations. Blood 1988;71:1361-1365.
30. van Giezen JJJ, Bouma MBN, Jansen JWCM. Cross-linking of alfa2-antiplasmin to fibrin is a key factor in regulating blood clot lysis: species differences. Blood Coag Fibrinol 1993;4:869-875.
31. Mosesson MW. Fibrin polymerization and its regulatory role in hemostasis. J Lab Clin Med 1990;116:8-17.
32. Biemond BJ, Friederich PW, Levi M, Vlasuk GP, Büller HR, Cate JW. Comparison of sustained antithrombotic effects of inhibitors of thrombin and factor Xa in experimental thrombosis. Circulation 1996;93:153-160.